Nucleobase-Inspired Self-Adhesive and Inherently Antibacterial Hydrogel for Wound Dressing

Yan, Jia; Ji, Yanzheng; Huang, Ming; Li, Tao; Liu, Qing; Lü, Shaoyu; Liu, Mingzhu

doi:10.1021/acsmaterialslett.0c00304

Cited by 53 publications

(53 citation statements)

References 30 publications

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“…The Fourier transform infrared spectroscopy (FT-IR) spectra of the washed gel also supports the complete removal of GA; the IR details are briefly explained in “ Characterization of GbH ” section. The stickiness of the GbH to the wet surface is enabled by the surface amine groups present on the hydrogel 27 , 28 . The GbH was kept on diverse surfaces (overnight at RT) and the stickiness of each hydrogel to the surface was observed (Fig.…”

Section: Resultsmentioning

confidence: 99%

Bioinspired gelatin based sticky hydrogel for diverse surfaces in burn wound care

George

Bhatia

Kumar

et al. 2022

Sci Rep

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Proper burn wound management considers patient’s compliance and provides an environment to accelerate wound closure. Sticky hydrogels are conducive to wound management. They can act as a preventive infection patch with controlled drug delivery and diverse surface adherence. A hypothesis-driven investigation explores a bioinspired polydopamine property in a gelatin-based hydrogel (GbH) where polyvinyl alcohol and starch function as hydrogel backbone. The GbH displayed promising physical properties with O–H group rich surface. The GbH was sticky onto dry surfaces (glass, plastic and aluminium) and wet surfaces (pork and chicken). The GbH demonstrated mathematical kinetics for a transdermal formulation, and the in vitro and in vivo toxicity of the GbH on test models confirmed the models’ healthy growth and biocompatibility. The quercetin-loaded GbH showed 45–50% wound contraction on day 4 for second-degree burn wounds in rat models that were equivalent to the silver sulfadiazine treatment group. The estimates for tensile strength, biochemicals, connective tissue markers and NF-κB were restored on day 21 in the GbH treated healed wounds to imitate the normal level of the skin. The bioinspired GbH promotes efficient wound healing of second-degree burn wounds in rat models, indicating its pre-clinical applicability.

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Section: Resultsmentioning

confidence: 99%

Bioinspired gelatin based sticky hydrogel for diverse surfaces in burn wound care

George

Bhatia

Kumar

et al. 2022

Sci Rep

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“…The environmental concern of oil-containing adhesives has stimulated the development of green and eco-friendly adhesives whose synthesis and application generate minimized or neglected environmental pollution. − In this scenario, much effort has been devoted to the fabrication of water-based adhesives consisting of water-soluble or water dispersed polymers/nanoobjects. ,, Typical examples include water-based adhesives of supramolecular complexes, , complex coacervates, − well-aligned cellulose nanocrystals, , stitching polymers enabling topological adhesion, , and so forth . Of particular interest is that these adhesives can realize reversible adhesion, , anisotropic adhesion, and adhesion of wet materials such as tissues and hydrogels. ,− ,− Despite these achievements, the practical application of water-based adhesives requires overcoming problems such as relatively lower adhesion strength than oil-containing adhesives, tedious preparative process, and the use of expensive and environmental unfriendly chemicals in their synthesis. ,, …”

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confidence: 99%

Superstrong Water-Based Supramolecular Adhesives Derived from Poly(vinyl alcohol)/Poly(acrylic acid) Complexes

Wang

et al. 2021

ACS Materials Lett.

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It remains a great challenge for low-cost and mass fabrication of water-based adhesives with good adhesion performance. In this study, superstrong water-based supramolecular adhesives with long-term stability are fabricated by complexation of commercially available poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA) in aqueous solution. The gel-like PVA/PAA adhesives can be conveniently injected and spread on targeted location for firm adhesion of various adherends such as glass, metals, and woods. The PVA/PAA adhesives achieve an adhesion strength of ∼5.9 MPa toward glass substrates and ∼14.3 MPa toward woods. The dried PVA/PAA adhesives are cross-linked with high density of hydrogen bonds between PVA and PAA as well as the physical entanglement of polymer chains, which determines the cohesive force of the adhesives. The adhesive surface has abundant noncomplexed hydroxyl and/or carboxylic acid groups, which can establish hydrogen bonds, coordination bonds, and van der Waals interactions with the surfaces of adherends to enable superstrong adhesion. The incorporation of Laponite RD (Lap) clays can further enhance the adhesion strength of the resultant PVA/PAA-Lap adhesives. As a result, the wooden bridge adhered by the PVA/PAA-Lap adhesive with an adhesive area of 50 mm × 50 mm can carry a weight of ∼179 kg without break.

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“…Hence, low molecular weight gelators (LMWGs) 11,12 such as nucleobase 13,14 and peptide 15 based inherent antibacterial hydrogel could be an efficient candidate to resolve this problem.…”

Section: Introductionmentioning

confidence: 99%

Dynamic Multicomponent Reactions Directed Self-assembled G-quadruplex Inherent Antibacterial Hydrogel

Rit

Ghosh

Patidar

et al. 2022

Preprint

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Now-a-days inherent antibacterial hydrogels have gained significant attention due to their utilization against infectious bacteria. Herein, we focus on the development of injectable, self-healable, dynamic, G-quadruplex hydrogel with inherent antibacterial activity. The dynamic self-assembled hydrogel is constructed upon multicomponent reactions (MCR) among guanosine, 2-formylphenylboronic acid and amino acid/peptides in presence of potassium ions. The role of amino acid/peptides toward the formation of G-quadruplex hydrogel is studied in details. G-quadruplex structure is formed via the π-π stacking of G-quartets. The formation of G-quadruplex is investigated by thioflavin T binding assay, CD spectroscopy and PXRD. The formation of the dynamic imino-boronate bond in the hydrogels is well characterised by temperature dependent 11B NMR (VT-NMR) and FT-IR spectroscopy. Furthermore HR-TEM images and rheological experiments reveal the fibrillar networks and the viscoelastic property of the hydrogels. The presence of the dynamic imino-boronate ester bonds makes the hydrogel injectable and self-healable in nature. These dynamic G-quadruplex hydrogels show potential antibacterial activity against a series of Gram positive and Gram negative bacteria. Such injectable and self-healable hydrogels could be used in various applications in the field of biomedical science.

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Nucleobase-Inspired Self-Adhesive and Inherently Antibacterial Hydrogel for Wound Dressing

Cited by 53 publications

References 30 publications

Bioinspired gelatin based sticky hydrogel for diverse surfaces in burn wound care

Bioinspired gelatin based sticky hydrogel for diverse surfaces in burn wound care

Superstrong Water-Based Supramolecular Adhesives Derived from Poly(vinyl alcohol)/Poly(acrylic acid) Complexes

Dynamic Multicomponent Reactions Directed Self-assembled G-quadruplex Inherent Antibacterial Hydrogel

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