Bioinspired gelatin based sticky hydrogel for diverse surfaces in burn wound care

Abstract

Proper burn wound management considers patient’s compliance and provides an environment to accelerate wound closure. Sticky hydrogels are conducive to wound management. They can act as a preventive infection patch with controlled drug delivery and diverse surface adherence. A hypothesis-driven investigation explores a bioinspired polydopamine property in a gelatin-based hydrogel (GbH) where polyvinyl alcohol and starch function as hydrogel backbone. The GbH displayed promising physical properties with O–H group rich surface. The GbH was sticky onto dry surfaces (glass, plastic and aluminium) and wet surfaces (pork and chicken). The GbH demonstrated mathematical kinetics for a transdermal formulation, and the in vitro and in vivo toxicity of the GbH on test models confirmed the models’ healthy growth and biocompatibility. The quercetin-loaded GbH showed 45–50% wound contraction on day 4 for second-degree burn wounds in rat models that were equivalent to the silver sulfadiazine treatment group. The estimates for tensile strength, biochemicals, connective tissue markers and NF-κB were restored on day 21 in the GbH treated healed wounds to imitate the normal level of the skin. The bioinspired GbH promotes efficient wound healing of second-degree burn wounds in rat models, indicating its pre-clinical applicability.

Type-A Gelatin-Based Hydrogel Infiltration and Degradation in Titanium Foams as a Potential Method for Localised Drug Delivery

“…3 times higher than that of the 2% (0.46 ± 0.15 and 0.16 ± 0.04 um, respectively). The SEM images obtained revealed a similar microstructure as previously shown by Sanchez-Cid et al with the development of collagen-based hydrogels [ 48 ] or by George et al with gelatin-based hydrogels [ 49 ].…”

Bioadhesive Technology Platforms

“…This typically entails maintaining a moist environment, allowing gas permeation and exudate drainage and discouraging microbial activity. Bioadhesive hydrogels are compelling candidates for these purposes, as they possess soft, tissue-like water contents and provide secure attachment to the skin, safeguarding the wound. − Furthermore, they can be loaded with antimicrobial or antioxidant agents, such as silver nanoparticles or lignin, to prevent bacterial infection and oxidative stress. − Recently, advanced wound dressings with electrical and mechanical modulatory functions have emerged, which are discussed in detail in Section .…”

Engineering multifunctional adhesive hydrogel patches for biomedical applications

“…The patches discussed here are excellent for the local delivery of therapeutics for treating chronic wounds. 159,160 Beyond local delivery at the wound sites, these sticky patches are excellent for delivering systemic transdermal medication because of their (i) biocompatibility, (ii) biodegradability, (iii) ability to load drugs, (iv) ability to sustain the release of the loaded drugs at a predetermined rate, and (v) ability to allow for cell attachment and infiltration. However, because of the barriers presented by the outermost layer of skin (epidermis), very few therapeutic molecules can be delivered to the bloodstream using skin-based simple polymeric hydrogel patches.…”