Bioadhesive Technology Platforms

Abstract

Bioadhesives have emerged as transformative and versatile tools in healthcare, offering the ability to attach tissues with ease and minimal damage. These materials present numerous opportunities for tissue repair and biomedical device integration, creating a broad landscape of applications that have captivated clinical and scientific interest alike. However, fully unlocking their potential requires multifaceted design strategies involving optimal adhesion, suitable biological interactions, and efficient signal communication. In this Review, we delve into these pivotal aspects of bioadhesive design, highlight the latest advances in their biomedical applications, and identify potential opportunities that lie ahead for bioadhesives as multifunctional technology platforms.

Natural polyphenolic antibacterial bio-adhesives for infected wound healing

“…Noting that the pig skin exhibited strong adhesion performances (∼300 kPa), which met the requirements of bio-tissues according to previous reports in the literature. 19,46–48 So, the excellent tissue adhesion performance of the MTA natural bioadhesives was further verified by using a tissue cutting repair process. In brief, various tissues including heart, liver, spleen, stomach, and kidney were made into a 5 mm wound using scissors, and the MTA natural bio-adhesives were applied onto the wound surface to achieve adhesion.…”

Multilevel Micronanoscale Texture Effects on Fly Wing Membrane–Water Droplet Interaction

“…An insect wing was taken from hoverflies in Henan, China, repelling the impacting free-falling raindrops like the other examples in Figure a, including lotus leaf surfaces, wheat leaves, cicada wing, filefish skin, springtail skin, duck feathers, seat on insect legs, torrent frog, and tree frog foot. , Those individual wetting states or combined wetting states are harnessed in multiple actual usage scenarios, including self-cleaning, anti-icing, antifogging, anticorrosion, controlling bioadhesion, cell capture, and water–oil separation. − …”

Silk fibroin hydrogel adhesive enables sealed-tight reconstruction of meniscus tears

“…On the one hand, an in-situ photocurable instant S-PIL10 was fabricated, which fulfilled the gaps between the torn meniscus tissue and formed the mechanical interlocking to improve interfacial adhesion 57 . Actually, noncovalent interactions play an important role in achieving fast interfacial bonding and contributing to adhesion stability 58 . S-PIL10 could provide noncovalent interactions in tissue adhesion including electrostatic interactions and hydrogen bonds due to its various active functional groups.…”