Natural polyphenolic antibacterial bio-adhesives for infected wound healing

Zhang, Hengjie; Feng, Yuqi; Wang, Tianyou; Zhang, Jianhua; Song, Yuxian; Zhang, Jing; Li, Yiwen; Zhou, Dingzi; Gu, Zhipeng

doi:10.1039/d3bm02122j

Cited by 2 publications

(2 citation statements)

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“…1 Currently, bacterial infection is a primary challenge in wound treatment, as the formation of exudate due to bacterial infection hinders wound repair. 2, 3 The issue of bacterial infection induced by pathogenic bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, Clostridium, Streptococcus, etc.) is one of the greatest worldwide challenges that urgently needs to be addressed globally.…”

Section: Introductionmentioning

confidence: 99%

“…As a complex physiological process, wound healing requires the high degree of coordination among different types of cells, chemokines, cytokines, and various growth factors in successive healing steps . Currently, bacterial infection is a primary challenge in wound treatment, as the formation of exudate due to bacterial infection hinders wound repair. , The issue of bacterial infection induced by pathogenic bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, Clostridium , Streptococcus , etc.) is one of the greatest worldwide challenges that urgently needs to be addressed globally .…”

Section: Introductionmentioning

confidence: 99%

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Thiosemicarbazones-Loaded Injectable Hydrogels with Self-Healing and Antibacterial Activity for Wound Healing

Wang,

Su,

et al. 2024

ACS Appl. Polym. Mater.

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An injectable hydrogel loading α-N-heterocyclic thiosemicarbazones with antibacterial activity was designed to attain therapy against wounds with high efficiency. In the present study, the injectable FPZ-H 2 L hydrogel was synthesized by loading 2,6-diacetylpyridine bis(N 4 -methylthiosemicarbazone) (H 2 L) on transition-metal ions (Zn 2+ )-cross-linked-folic acid (FA)-co-polydopamine (PDA) hydrogel (FPZ hydrogel). The injectable hydrogel (FPZ-H 2 L) cross-linked by coordination and hydrogen bonds displayed an excellent self-healing performance and completely covered the irregular wound. Compared with the FPZ hydrogel, the FPZ-H 2 L hydrogel has stronger antibacterial efficacy on typical Gram-positive/negative bacteria and drug-resistant bacteria. The antibacterial mechanisms of the hydrogel were related to biofilm ablation, the disruption of the cell membrane integrity, leakage of nucleic acids and proteins, and the production of oxidative stress response, thus causing bacterial death. Cell Counting Kit-8 (CCK-8) test shows that FPZ-H 2 L hydrogel has excellent cell compatibility, and gel drug loading technology greatly overcomes the problem of high cytotoxicity of H 2 L. The wound healing experiments indicated that the hydrogel enhanced the wound healing efficacy of mice. These results prove that the mixed hydrogel has broadened the field of vision for the design of antibacterial wound dressings.

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Section: Introductionmentioning

confidence: 99%