Developing hydrogel wound dressings with antibacterial activity and reproducible adhesion ability is an urgent need in biomaterial sciences. However, present hydrogel wound dressings either employ inorganic antibacterial agents such as Ag and metallic oxide nanoparticles, which have dosage dependence and unsatisfactory biocompatibility, or load antibiotics, evolving drug-resistant bacteria. Here a nucleobase-inspired self-adhesive and inherently antibacterial hydrogel is reported as a wound dressing. The hydrogel was developed from poly(3-dimethyl(methacryloyloxyethyl)ammonium propanesulfonate)-co-poly(methacryloylamidoadenine) (PDMAPS-co-PMA-Ade) and chitosan. The DMAPS moieties endow the hydrogel with an anti-fouling property, while special interactions between nucleobase-modified MA-Ade provide facile molecular recognition with corresponding groups on the surface of tissues. In vivo cutaneous wound repair determination demonstrated that the hydrogel-treated mice showed no hemorrhage, less inflammation, and fewer neovessels than the control after 14 days. This achievement offers an opportunity to facilitate significant wound healing without the aid of other antibiotics.
The development of modern agriculture has prompted the greater input of herbicides, insecticides, and fertilizers. However, precision release and targeted delivery of these agrochemicals still remain a challenge. Here, a pesticide-fertilizer all-in-one combination (PFAC) strategy and deep learning are employed to form a system for controlled and targeted delivery of agrochemicals. This system mainly consists of three components: (1) hollow mesoporous silica (HMS), to encapsulate herbicides and phase-change material; (2) polydopamine (PDA) coating, to provide a photothermal effect; and (3) a zeolitic imidazolate framework (ZIF8), to provide micronutrient Zn2+ and encapsulate insecticides. Results show that the PFAC at concentration of 5 mg mL–1 reaches the phase transition temperature of 1-tetradecanol (37.5 °C) after 5 min of near-infrared (NIR) irradiation (800 nm, 0.5 W cm–2). The data of corn and weed are collected and relayed to deep learning algorithms for model building to realize object detection and further targeted weeding. In-field treatment results indicated that the growth of chicory herb was significantly inhibited when treated with the PFAC compared with the blank group after 24 h under NIR irradiation for 2 h. This system combines agrochemical innovation and artificial intelligence technology, achieves synergistic effects of weeding and insecticide and nutrient supply, and will potentially achieve precision and sustainable agriculture.
With the frequent occurrence of thrombus diseases, thrombus has become a factor endangering human health. Nattokinase (NK) is a new generation of thrombolytic drug with efficient thrombolytic effect and no major side effects. However, it is easily inactivated in external environment due to its sensitivity, which is still a challenge for its generalized application. Herein, a mesoporous silica/polyglutamic acid peptide dendrimer (M‐MSNs‐G3‐RGD) nanoparticle was prepared to protect and transport NK. First, magnetic mesoporous silica nanoparticles (M‐MSNs) were prepared as the core of the whole nanoparticle, then polyglutamic acid peptide dendrimer (G3) was bonded to form M‐MSNs‐G3. At last, arginine‐glycine‐aspartic peptide (RGD) was grafted onto the M‐MSNs‐G3 to obtain M‐MSNs‐G3‐RGD. The physical and chemical characteristics and biological toxicity of M‐MSNs‐G3‐RGD were studied. Thrombus‐targeting nanocomposites M‐MSNs‐G3‐RGD/NK were prepared by loading the thrombolytic drug NK via electrostatic interaction. In vitro and in vivo targeted thrombolytic experiments showed that the nanoparticles exhibited significant thrombolysis ability. These results suggested the potential application of M‐MSNs‐G3‐RGD/NK in dual targeted thrombolysis.
efficiency of fertilizer and pesticide is growing to solve these problems. [8][9][10] Controlled release pesticide-fertilizer combination (CRPFC), playing a synergistic effect of pesticide and fertilizer, is an effective approach to achieve sustainable circulative agriculture and has garnered considerable attention all over the world. [11,12] Compared with traditional controlledrelease pesticide or fertilizer, CRPFC unifies the two most important agrochemicals used in agriculture, and combine the plant protection of pesticide and the nutrients supply of fertilizer into one field operation. It cannot only save labor but also reduce time and energy consumption. Various materials have been developed recently to be used as carriers of pesticide and fertilizer, such as organic polymers, [13] bio-sourced matrices, [14] and inorganic materials. [15,16] However, most of them only provide individual function and are accompanied by complex preparation processes. Furthermore, they are very susceptible to being washed away by rain, which limit their real applications. [17] Therefore, develop an adhesive carrier for extensive use of CRPFC in agriculture is still a challenge.Nanotechnology represents a new direction for the carrier development. [18][19][20][21] Over the past years, the applications and benefits of nanotechnology, especially nanoparticles as pesticide or fertilizer carrier platforms, have generated immense developments. [22][23][24] Recently, mesoporous silica nanoparticles (MSNs) show superior performance as support for fertilizer or pesticide controlled release due to their easy functionalization modification, controllable morphology, adjustable pore volume, and thermal stability. [25][26][27][28][29] However, the adsorption capacity of MSNs was a great limitation because there are no functional sites on MSNs surface. [30] It was reported that by grafting highdensity carboxyl groups onto the pore surface of MSNs and complexing with platinum atoms, the drug loading efficiency of MSNs can be greatly improved. [31] In this work, MSNs functionalized by positive charges were developed to achieve a high loading capacity of pesticide and fertilizer (Scheme 1). Then the nanoparticles were coated by polydopamine (PDA) via self-polymerization. [32][33][34] As a kind of catecholamines, PDA is expected to be active for metals ions, [35] The volatilization and leaching for most fertilizers and pesticides raise questions about the sustainability of ecosystems. To enhance the utilization of fertilizers and pesticides, pesticide-fertilizer combined nanocomposites are developed to prolong foliar retention and play a synergistic effect of weeding and nourishing for plant growth. The pesticide-fertilizer combined nano composites are prepared based on positive-charge functionalized mesoporous silica and polydopamine, by chelating micronutrients (Zn 2+ ) and loading pesticide 2,4-D. A high loading capacity of Zn 2+ (233.4 mg g −1 ) and 2,4-D (17.8%) is achieved. Zn 2+ and the pesticide show excellent pH-responsive release behavio...
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