Activation cross sections of α-particle induced reactions on nat Yb were measured. Stacked foil technique, activation method and γ-ray spectrometry were used. The stacked target consisted of nat Yb and nat Ti foils was irradiated with a 51.0-MeV α beam at the RIKEN AVF cyclotron. The γ rays emitted from the irradiated foils were measured using a high-resolution HPGe detector. Production cross sections of 170,171,172,173,175 Hf, 171,172,173,177g Lu and 169 Yb were determined. The results were compared with previous experimental studies and theoretical calculations. For most of the reactions a consistent agreement was found.