Some nuclear chemical aspects of medical generator nuclide production at the Los Alamos hot cell facility

Fassbender, Michael E.; Nortier, F.M.; Phillips, Dennis; Hamilton, V.; Heaton, R.C.; Jamriska, D.J.; Kitten, J. J.; Pitt, L. R.; Salazar, L. L.; Valdez, F. O.; Peterson, E.J.

doi:10.1524/ract.92.4.237.35596

Cited by 27 publications

(12 citation statements)

References 34 publications

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“…The results presented here for production of 88 Y and 88 Zr do not change the earlier conclusions. The proton and deuteron induced reactions on niobium can only be a taken into account as a satellite or by-product production method (for example production in the target holders made from niobium used in production of long-lived 69Ge from gallium targets [35,36]).…”

Section: Y Productionmentioning

confidence: 99%

Activation cross sections of deuteron induced reactions on niobium in the 30–50 MeV energy range

Ditrói

Tárkányi

Takács

et al. 2016

Nuclear Instruments and Methods in Physics Research Section B:

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Section: Y Productionmentioning

confidence: 99%

Activation cross sections of deuteron induced reactions on niobium in the 30–50 MeV energy range

Ditrói

Tárkányi

Takács

et al. 2016

Nuclear Instruments and Methods in Physics Research Section B:

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“…The solid target technique is also superior, even mandatory, when large activities of radionuclides with longer half-lives (including a large number of radiometals) are required, as it enables simultaneously the use of larger beam currents (improved solid target assemblies stand up to hundreds of μA, while recently developed liquid targets only stand up to 140 μA), higher densities of target nuclides while also providing superior production yields. For instance, some studies report irradiations accumulating tens of thousands of μAh (Meinken et al 2005;Fassbender et al 2004).…”

Section: The Production Of Radiometalsmentioning

confidence: 99%

Production of radiometals in liquid targets

Carmo

Scott

Alves

2020

EJNMMI radiopharm. chem.

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Over the last several years, the use of radiometals has gained increasing relevance in supporting the continuous development of new, complementary and more specific biological targeting agents. Radiopharmaceuticals labelled with radiometals from elements such as Tc, Zr, Y, Ga and Cu received increasing attention as they find application in both diagnostic SPECT and PET imaging techniques and radiotherapeutic purposes. Such interest stems from the wide variety of radionuclides available with distinct and complementary nuclear decay characteristics to choose from with unequalled specificity, but can also be explained by growing demand in targeted radionuclide therapy. As a result, as routine supply of these radiometals becomes mandatory, studies describing their production processes have expanded rapidly. Although most radiometals are traditionally provided by the irradiation of solid targets in specialized cyclotrons, recently developed techniques for producing radiometals through the irradiation of liquid targets have received growing attention due to compatibility with commonly available small medical cyclotrons, promising characteristics and encouraging results. Irradiating liquid targets to produce radiometals appears as a fast, reliable, convenient and costefficient alternative to the conventional solid target techniques, characterized by complex and time-consuming pre-and post-irradiation target handling. Production of radiometals in liquid targets incorporated to complete manufacturing processes for daily routine is already recognized as a viable alternative and complementary supply methodology to existing solid target based infrastructures to satisfy growing clinical demands. For instance, several sites already use the approach to produce 68 Ga-radiopharmaceuticals for clinical use. This review article covers the production of common radiometals with clinical potential through the irradiation liquid targets. A comparison with the traditional solid target irradiation methods is presented when relevant.

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“…The information was used to develop a Te/Sb separation procedure that (1) was compatible with large nat Sb (25 g) targets, (2) accounted for safety concerns associated with generating large quantities of 119m Te/ 119 Sb, and (3) could be rapidly (∼36 h separation) carried out using remote handling techniques within hot cells. 41 We are most excited by the fact that the final 119m Te/ 119 Sb product could be isolated as a chemically pure sample, in reasonable yield, and with high specific activity. Provided an appropriate 119 Sb generator can be designed that meets strict requirements from the Food and Drug Administration (FDA), this 119m Te/ 119 Sb production route also shows potential for compatibility with active pharmaceutical ingredients (APIs).…”

Section: Introductionmentioning

confidence: 99%

Large-Scale Production of ^119mTe and ¹¹⁹Sb for Radiopharmaceutical Applications

et al. 2019

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Radionuclides find widespread use in medical technologies for treating and diagnosing disease. Among successful and emerging radiotherapeutics, 119 Sb has unique potential in targeted therapeutic applications for low-energy electron-emitting isotopes. Unfortunately, developing 119 Sb-based drugs has been slow in comparison to other radionuclides, primarily due to limited accessibility. Herein is a production method that overcomes this challenge and expands the available time for large-scale distribution and use. Our approach exploits high flux and fluence from high-energy proton sources to produce longer lived 119m Te. This parent isotope slowly decays to 119 Sb, which in turn provides access to 119 Sb for longer time periods (in comparison to direct 119 Sb production routes). We contribute the target design, irradiation conditions, and a rapid procedure for isolating the 119m Te/ 119 Sb pair. To guide process development and to understand why the procedure was successful, we characterized the Te/Sb separation using Te and Sb K-edge X-ray absorption spectroscopy. The procedure provides low-volume aqueous solutions that have high 119m Te—and consequently 119 Sb—specific activity in a chemically pure form. This procedure has been demonstrated at large-scale (production-sized, Ci quantities), and the product has potential to meet stringent Food and Drug Administration requirements for a 119m Te/ 119 Sb active pharmaceutical ingredient.

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Some nuclear chemical aspects of medical generator nuclide production at the Los Alamos hot cell facility

Abstract: Generator nuclides constitute a convenient tool for applications in nuclear medicine. In this paper, some radiochemical aspects of generator nuclide parents regularly processed at Los Alamos are introduced. The bulk production of the parent nuclides

Cited by 27 publications

References 34 publications

Activation cross sections of deuteron induced reactions on niobium in the 30–50 MeV energy range

Activation cross sections of deuteron induced reactions on niobium in the 30–50 MeV energy range

Production of radiometals in liquid targets

Large-Scale Production of ^119mTe and ¹¹⁹Sb for Radiopharmaceutical Applications

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Some nuclear chemical aspects of medical generator nuclide production at the Los Alamos hot cell facility

Abstract: Generator nuclides constitute a convenient tool for applications in nuclear medicine. In this paper, some radiochemical aspects of generator nuclide parents regularly processed at Los Alamos are introduced. The bulk production of the parent nuclides

Cited by 27 publications

References 34 publications

Activation cross sections of deuteron induced reactions on niobium in the 30–50 MeV energy range

Activation cross sections of deuteron induced reactions on niobium in the 30–50 MeV energy range

Production of radiometals in liquid targets

Large-Scale Production of 119mTe and 119Sb for Radiopharmaceutical Applications

Contact Info

Product

Resources

About

Large-Scale Production of ^119mTe and ¹¹⁹Sb for Radiopharmaceutical Applications