Nuclear Lobulation and Cytoplasmic Fibrils in Leukemic Plasma Cells

Plasma Cell Neoplasms Showing Multilobulated Nuclei

“…Cases of plasma cell dyscrasias with excessively convoluted or multilobulated nuclei have been reported rarely [1,2,3,4,5,6,7,8,9,10,11,12,13,14]. Aggressive clinical courses were seen in these reports, supporting the notion that extensive nuclear lobulation correlates with poor prognosis.…”

“…Plasma cell neoplasms, on rare occasions, have been reported to have multilobulated nuclei [1,2,3,4,5,6,7,8,9,10,11,12,13,14]. Since the first report of this unusual morphology in 1972 [1], 14 publications including 29 reported cases were found in the PubMed database using the key words ‘plasma cell', ‘cleaved' and ‘multilobulated'.…”

“…Since the first report of this unusual morphology in 1972 [1], 14 publications including 29 reported cases were found in the PubMed database using the key words ‘plasma cell', ‘cleaved' and ‘multilobulated'. To evaluate the characteristics of these reports, the searched publications were summarized, as shown in online supplementary table S1 (for all online suppl.…”

Cytoplasmic Fibrils in Plasma Cell Leukemia

“…Cytoplasmic fibrils have also been observed in mar row plasma cells of a few patients with myeloma [13,21,22], but not in those from a large number of patients with multiple myeloma [2,4,5,7,10,22,25], The incidence of these fibrils in plasma cell leukemia, howev er, appears to be extremely high. Prominent cytoplasmic fibrils have been reported in the circulating plasma cells from 4 [1,3,8,24] out of 6 [1,3,8,18,23,24] cases with plasma cell leukemia examined ultrastructurally.…”

Plasma cell leukemia with lobulated nuclei: One case report

“…3 There have been only a few reports describing the ultrastructure of neoplastic cells with multilobulated nuclei. [4][5][6] The combination of these features, such as is seen in plasma cell leukemia with lobulated nuclei, is rare enough to warrant further investigation. We present a case of plasma cell leukemia in which the neoplastic cells had lobulated nuclei.…”