Cytoplasmic Fibrils in Plasma Cell Leukemia

Ogawa, Makio; Preston, Ronald A.; Carson, Matthew D.; Komiyama, Atsushi; Spicer, Samuel S.

doi:10.1159/000207928

Cited by 11 publications

(4 citation statements)

References 10 publications

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“…Somewhat similar observations to ours, though referring to plasmocytes, were reported by Ogawa et al (1976). These authors identified vast numbers of fibrillar structures localized intracellularly with amyloid fibres.…”

Section: Discussionsupporting

confidence: 90%

Ultrastructural Aspects of Leukaemic Cells in Acute Myeloblastic Leukaemia

Nowakowski

Halliop

Tarach

1982

Scandinavian Journal of Haematology

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Ultrastructural aspects of leukaemic cells in a case of myeloblastic leukaemia are described. Changes concerning of mitochondria1 ultrastructure, but primarily the presence of vast numbers of fibrillar structures in the cytoplasm of the examined cells were observed. These structures were spreading through their gradual widening to cover almost the whole cell cytoplasm, damaging its organellae and internal architecture. The nature of the observed changes remains unknown.

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Section: Discussionsupporting

confidence: 90%

Ultrastructural Aspects of Leukaemic Cells in Acute Myeloblastic Leukaemia

Nowakowski

Halliop

Tarach

1982

Scandinavian Journal of Haematology

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“…A striking finding was the presence of abundant cytoplasmic fibrils in the majority of cells. These structures have been described in malignant plasma cells from multiple myeloma (20) but may occur with a higher frequency in PCL (6,21). The nature of these structures remains uncertain.…”

Section: Discussionmentioning

confidence: 98%

Primary plasma cell leukaemia: immunological and ultrastructural studies in 6 cases

Parreira¹,

Robinson²,

Melo³

et al. 1985

Scandinavian Journal of Haematology

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The clinical and laboratory studies of 6 patients with primary plasma cell leukaemia are described. The leukaemic cells had a variable morphology, ranging from lymphoplasmacytic and mature plasma cells to poorly differentiated blasts. The neoplastic plasma cells had a characteristic phenotype: they were positive for CyIg and the McAb OKTlO and Ri-3, and did not express the B-cell antigens la, B1 and B4. Ultrastructural studies confirmed the plasma cell nature of the leukaemic cells and showed the presence of a meshwork of cytoplasmic fibrils in 50 to 90% of the neoplastic cells from all cases. The distinct ultrastructural and immunological features of PCL described in this study will help the diagnosis and further characterisation of this disease entity.

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“…Pleural effusion in the absence of intrathoracic plasmocytoma has been ob served in only 6 patients, as reported in the French literature [18,19], in I of these the pleural effusion appeared concomitantly with pulmonary infection and receded fol lowing antibiotic therapy. Two additional patients with MM and pleural involvement [18,19] as well as 2 patients with plasma cell leukemia complicated by pleural effu sion have also been recently described [16,17].…”

Section: Discussionmentioning

confidence: 99%

Pleural Effusion – Presenting Sign in Multiple Myeloma

Shoenfeld¹,

Pick²,

Weinberger³

et al. 1978

Respiration

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A patient with multiple myeloma in whom recurrent right pleural effusion was the presenting sign of the disease is reported. An IgA (k) monoclonal component was found in both the pleural effusion and the serum. The bone marrow specimen was interpreted as typical for multiple myeloma and the pleural fluid contained numerous plasma cells. Treatment with cyclophosphamide was followed by clinical improvement and the disappearance of the pleural effusion. The clinical picture of symptomatic multiple myeloma (MM) is dominated by signs and symptoms attributed to bone marrow infiltration by the neoplastic cells and bone destruction [1]. Extraosseous involvement in MM is uncommon and pleural involvement is even more rare [2–4]. We describe a patient with MM in whom the presenting sign of the disease was a recurrent right pleural effusion which disappeared following treatment with cyclophosphamide.

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Cytoplasmic Fibrils in Plasma Cell Leukemia

Cited by 11 publications

References 10 publications

Ultrastructural Aspects of Leukaemic Cells in Acute Myeloblastic Leukaemia

Ultrastructural Aspects of Leukaemic Cells in Acute Myeloblastic Leukaemia

Primary plasma cell leukaemia: immunological and ultrastructural studies in 6 cases

Pleural Effusion – Presenting Sign in Multiple Myeloma

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