Nuchal Nevus flammeus as a Skin Marker of Prognosis in Alopecia areata

Hatzis, J.; Kostakis, Panagiotis; Tosca, Androniki; Parissis, N.; Nicolis, G.; Varelzidis, A.; Stratigos, J.

doi:10.1159/000248533

Cited by 13 publications

(18 citation statements)

References 2 publications

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“…Studies showed that the prevalence of nuchal nevus flammeus (NNF) was significantly increased in patients with AA, especially severer forms [10,11,12]. We also conducted a study to investigate whether AA is associated with NNF.…”

Section: Introductionmentioning

confidence: 99%

The Association between Nuchal Nevus Flammeus and Alopecia Areata: A Case-Control Study

et al. 2005

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Background: The association of alopecia areata (AA) with nuchal nevus flammeus (NNF) has been demonstrated by previous studies. Objectives: The aim of this study was to investigate whether AA is associated with NNF. Methods: 199 AA patients and 215 controls without AA were examined for the presence of NNF. Results: 35 patients (17.6%) in the AA group had NNF. In the control group, 20 patients (9.3%) had NNF (odds ratio = 2.08, 95% confidence interval 1.43–2.73; p = 0.013). A statistically significant association was found between the presence of NNF and duration of the AA (p < 0.001). The presence of NNF was associated with severity of AA (p < 0.001). Conclusions: The results of our study suggest a link between NNF and AA especially in severer and more chronic forms.

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Section: Introductionmentioning

confidence: 99%

The Association between Nuchal Nevus Flammeus and Alopecia Areata: A Case-Control Study

et al. 2005

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“…Araştırmamızın sonuçları, uzun hastalık süresinin kötü prognoz göstergesi olduğunu destekler niteliktedir. Nevus flammeus AA'lı hastalarda sıktır ve kötü prognozu gösterir 5,20 . Araştırmamızda %14,9 oranında saptanan nevus flammeus, şiddetli tutulum gösteren olgularda yüksek (p=0,017) bulundu.…”

Section: Discussionunclassified

“…Alopesi areatanın patogenezi tam olarak bilinmemekte ise de günümüzdeki baskın görüş, genetik yatkınlığı olan bireylerde, çevresel tetikleyicilerle kıl foliküllerine karşı gelişen organ spesifik otoimmün bir hastalık olduğu yönündedir 1,2 . Bu çalışmada polikliniğimize başvuran AA'lı hastaların, klinik ve demografik özellikleri ile hastalık seyrindeki kötü prognostik faktörleri incelenerek, AA'nın Türkiye'deki epidemiyolojik özelliklerinin tanınmasına katkı amaçlandı 1,4,5 .…”

Section: Introductionunclassified

An investigation of poor prognostic factors in patients with alopecia areata and their relatives

Duman¹,

Köse²,

İşsever³

2015

TURKDERM

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Background and Design: Alopecia areata (AA) is characterized by non-ciatricial hair loss with exacerbations and remissions. Although its etiopathogenesis is not known, autoimmune factors have been suggested. Our aim was to make contribution to the epidemiological properties of AA in Turkey, and to determine the poor prognostic factors that affect the course of the disease. Materials and Methods: One hundred and thirty-four patients who applied to the dermatology and venereology outpatient clinic of Istanbul Medical Faculty were included in the study. The patients were retrospectively investigated in terms of age, gender, clinical type, the area affected by alopecia, severity of the disease, number of relapses, disease duration, age at disease onset, presence of nevus flammeus, nail involvement, history of emotional and/or physical stress, family history of AA, family and personal history of atopy. Results: Of the 134 patients, 79 (59 percent) were male, 55 (41 percent) were female and M/F ratio was 1.4/1. The clinical type was AA in 86.5%, alopecia totalis (AT) in 3.7% and alopecia universalis (AU) in 9.7% of the cases. The most common involvement was the scalp in both genders and 92.1% of them had patch pattern. Severe involvement was found to be significant in the female patients (p=0.029), in those with juvenile onset (p=0.001), and ≥1 year of disease duration (p=0.001) as well as in the presence of nevus flammeus (p=0.017) and nail involvement (p=0.015). A family history of AA was present in 27.6% of the cases and it was more common in the juvenile group (p=0.034). There was no association between the severity of the disease and atopy.

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“…Ense yerleşimli nevüs flammeus ile ilgili birkaç çalışma yapılmıştır ve daha dirençli ve ciddi AA tipleri için belirteç olabileceği öne sürülmüştür (20)(21)(22). Oğuz ve ark.…”

Section: Discussionunclassified

Retrospective Evaluation of Alopecia Areata Patients

Gönül¹,

Gül²,

Piskin³

et al. 2011

Turk J Dermatol

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Amaç: Son bir yıl içinde polikliniğimize başvuran alopesi areatalı hastaların klinik demografik ve laboratuar özelliklerini değer-lendirmeyi amaçladık. Gereç ve Yöntemler: Çalışma geriye dönük olarak yapıldı ve hastaya ait yaş, cinsiyet, hastalığın başlangıç yaşı, nüks sayısı, tutulum bölgeleri, aile öyküsü, eşlik eden bulgular ve yaptırmış olanların laboratuar bulguları kayıtlardan öğrenildi. Bulgular: Toplam 132 hasta çalışmaya alındı. Median hastalık süresi 4 aydı. Hastaların %15.9'u aile öyküsüne, %20.5'i başka bir otoimmün hastalığa, %18.2'si tırnak bulgusuna, %18.5'u atopi öyküsüne sahipti. Yüzde 6,5'inde ensede nevüs flammeus vardı. Çok odaklı tutulum anlamlı olarak erkeklerde fazlaydı. Hastalığın süresi ile şiddeti arasında pozitif korelasyon saptandı. Hastalık süresinin uzun olması ile tiroid otoantikorlarının yüksek olması ilişkili bulundu. Ensede nevüs flammeus olması total/ üniversal alopesi areata ile ilişkiliydi. Hastaların yaklaşık %10'unda demir, ferritin ve hemoglobin eksikliği tespit edildi. Sonuç: Çalışmamız alopesi areata ile ilişkili en fazla parametrenin araştırıldığı çalışmalardan biridir. Çalışmamızın sonuçlarına göre alopesi areatada erkek hakimiyeti vardır ve erkeklerde çok odaklı tutulum sık izlenmektedir. Erken başlangıç yaşı, atopi ve otoimmün hastalık birlikteliği prognozu etkilemezken tiroid oto antikor pozitifliği ve nevüs flammeus birlikteliği kötü prognoz göstergesi olabilir. (Turk J Dermatol 2011; 5: 43- AbstractObjective: We aimed to evaluate the clinical, demographic and laboratory features of alopecia areata (AA) patients who attended our policlinic in the last year. Material and Methods:The study was performed retrospectively and age, gender, family history of patients, onset age, duration and localization area of AA, number of recurrences, associated findings and laboratory findings were obtained from records. Results:The study included 132 patients. Median duration of disease was 4 months. 15.9% of the patients had a family history, 20.5% had another autoimmune disorder, 18% had nail findings, 18.5% atopy history. 6.5% of patients had nuchal nevus flammeus. Multifocal involvement was significantly higher in males. Positive correlation was detected between duration and severity of disease. The duration of disease was statistically related with increased thyroid autoantibodies. Nuchal nevus flammeus was related with total/universal AA. Low levels of iron, ferritin and hemoglobin were detected in approximately 10% of the patients. Conclusion: Our study is one of the studies investigating the largest parameters in AA patients. Our results indicate that there is a male dominance in AA and multifocal involvement is common in men. While early onset of disease, association with atopy and autoimmune disorder does not affect prognosis, antithyroid antibody positivity and association with nevus flammeus might be indicators of poorer prognosis. (Turk J Dermatol 2011; 5: 43-7)

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Nuchal Nevus flammeus as a Skin Marker of Prognosis in Alopecia areata

Cited by 13 publications

References 2 publications

The Association between Nuchal Nevus Flammeus and Alopecia Areata: A Case-Control Study

The Association between Nuchal Nevus Flammeus and Alopecia Areata: A Case-Control Study

An investigation of poor prognostic factors in patients with alopecia areata and their relatives

Retrospective Evaluation of Alopecia Areata Patients

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