The Association between Nuchal Nevus Flammeus and Alopecia Areata: A Case-Control Study

Akhyani, Maryam; Farnaghi, Fariba; Hassan, Sk. Sarif; Nazari, Rahman; Mansoori, Parisa; Taheri, Arash

doi:10.1159/000088503

Cited by 14 publications

(21 citation statements)

References 25 publications

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“…Araştırmamızın sonuçları, uzun hastalık süresinin kötü prognoz göstergesi olduğunu destekler niteliktedir. Nevus flammeus AA'lı hastalarda sıktır ve kötü prognozu gösterir 5,20 . Araştırmamızda %14,9 oranında saptanan nevus flammeus, şiddetli tutulum gösteren olgularda yüksek (p=0,017) bulundu.…”

Section: Discussionunclassified

An investigation of poor prognostic factors in patients with alopecia areata and their relatives

Duman¹,

Köse²,

İşsever³

2015

TURKDERM

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Background and Design: Alopecia areata (AA) is characterized by non-ciatricial hair loss with exacerbations and remissions. Although its etiopathogenesis is not known, autoimmune factors have been suggested. Our aim was to make contribution to the epidemiological properties of AA in Turkey, and to determine the poor prognostic factors that affect the course of the disease. Materials and Methods: One hundred and thirty-four patients who applied to the dermatology and venereology outpatient clinic of Istanbul Medical Faculty were included in the study. The patients were retrospectively investigated in terms of age, gender, clinical type, the area affected by alopecia, severity of the disease, number of relapses, disease duration, age at disease onset, presence of nevus flammeus, nail involvement, history of emotional and/or physical stress, family history of AA, family and personal history of atopy. Results: Of the 134 patients, 79 (59 percent) were male, 55 (41 percent) were female and M/F ratio was 1.4/1. The clinical type was AA in 86.5%, alopecia totalis (AT) in 3.7% and alopecia universalis (AU) in 9.7% of the cases. The most common involvement was the scalp in both genders and 92.1% of them had patch pattern. Severe involvement was found to be significant in the female patients (p=0.029), in those with juvenile onset (p=0.001), and ≥1 year of disease duration (p=0.001) as well as in the presence of nevus flammeus (p=0.017) and nail involvement (p=0.015). A family history of AA was present in 27.6% of the cases and it was more common in the juvenile group (p=0.034). There was no association between the severity of the disease and atopy.

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Section: Discussionunclassified

An investigation of poor prognostic factors in patients with alopecia areata and their relatives

Duman¹,

Köse²,

İşsever³

2015

TURKDERM

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“…Klinikte şiddetli başlangıç, ofiyazis bulunması, aile öyküsü bulunması, tırnak tutulumu olması, erken başlangıç yaşı, atopi ve diğer otoimmün hastalıkların birlikteliği kötü prognoz bulgusudur. 10 çalışmasında AA grubunda %17,5, kontrol grubunda %9,3 oranında NNF tespit edilmiş, uzun süren ve şiddetli hastalık grubunda NNF bulunması anlamlı olarak değerlendirilmiştir. Camacho ve ark.…”

Section: Discussionunclassified

Alopesi areatada nukal nevüs flammeus sıklığı

Agirgol¹,

Azaklı²,

Baş³

et al. 2014

TURKDERM

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Background and Design: There are only a few studies showing the increased frequency of nuchal nevus flammeus (NNF) in patients with alopecia areata (AA) when compared to the healthy population. Due to the fact that there are no studies conducted in our country on this topic, we aimed at investigating the NNF frequency in AA cases and evaluating the association of NNF with disease duration and severity. Materials and Methods: A total of 156 patients (F/M: 59/97; age range: 3-59 years) diagnosed with alopecia areata and 200 healthy controls (F/M: 91/109; age range: 3-60 years) were enrolled in the study. The patients were evaluated for disease type, duration, severity, age of onset, nail findings, and family history. All subjects were dermatologically examined for NNF. Results: NNF was diagnosed in 27 (17%) patients with alopecia areata and in 20 (10%) controls with a statistically significant difference (p=0.049). The frequency of NNF was significantly higher in patients with longer disease duration (p=0.024). Conclusion: These results conclude that NNF is more frequent in patients with alopecia areata and the presence of NNF might indicate a poor prognosis. (Turkderm 2014; 48: 92-4)

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“…Ense yerleşimli nevüs flammeus ile ilgili birkaç çalışma yapılmıştır ve daha dirençli ve ciddi AA tipleri için belirteç olabileceği öne sürülmüştür (20)(21)(22). Oğuz ve ark.…”

Section: Discussionunclassified

“…Çalışmamızın sonuçları ensede nevüs flammeus bulunması-nın kötü prognoz göstergesi olabileceğini göstermiştir. Nevüs flammeus alopesi areata birlikteliğinin patogenezi tam olarak bilinmemekle birlikte daha önce araştırmacılar tarafından alopesi areatadaki epidermal atrofinin ektatik subpapiller damarların görülebilmesini kolaylaştırması ile açıklanmaya çalışılmıştır (21). Ancak klinik olarak fokal alopesi areatası olan hastalarda ensede bulunan saçlar nedeniyle nevüs flammeusun hafif lezyonlarının gözden kaçabilmesi, o bölge-de saçların olmadığı alopesi totalis ve universalis gibi şiddet-li formlarda daha kolay fark edilir olması bu grupta göreceli olarak yüksek saptanmasına neden olmuş olabilir.…”

Section: Discussionunclassified

Retrospective Evaluation of Alopecia Areata Patients

Gönül¹,

Gül²,

Piskin³

et al. 2011

Turk J Dermatol

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Amaç: Son bir yıl içinde polikliniğimize başvuran alopesi areatalı hastaların klinik demografik ve laboratuar özelliklerini değer-lendirmeyi amaçladık. Gereç ve Yöntemler: Çalışma geriye dönük olarak yapıldı ve hastaya ait yaş, cinsiyet, hastalığın başlangıç yaşı, nüks sayısı, tutulum bölgeleri, aile öyküsü, eşlik eden bulgular ve yaptırmış olanların laboratuar bulguları kayıtlardan öğrenildi. Bulgular: Toplam 132 hasta çalışmaya alındı. Median hastalık süresi 4 aydı. Hastaların %15.9'u aile öyküsüne, %20.5'i başka bir otoimmün hastalığa, %18.2'si tırnak bulgusuna, %18.5'u atopi öyküsüne sahipti. Yüzde 6,5'inde ensede nevüs flammeus vardı. Çok odaklı tutulum anlamlı olarak erkeklerde fazlaydı. Hastalığın süresi ile şiddeti arasında pozitif korelasyon saptandı. Hastalık süresinin uzun olması ile tiroid otoantikorlarının yüksek olması ilişkili bulundu. Ensede nevüs flammeus olması total/ üniversal alopesi areata ile ilişkiliydi. Hastaların yaklaşık %10'unda demir, ferritin ve hemoglobin eksikliği tespit edildi. Sonuç: Çalışmamız alopesi areata ile ilişkili en fazla parametrenin araştırıldığı çalışmalardan biridir. Çalışmamızın sonuçlarına göre alopesi areatada erkek hakimiyeti vardır ve erkeklerde çok odaklı tutulum sık izlenmektedir. Erken başlangıç yaşı, atopi ve otoimmün hastalık birlikteliği prognozu etkilemezken tiroid oto antikor pozitifliği ve nevüs flammeus birlikteliği kötü prognoz göstergesi olabilir. (Turk J Dermatol 2011; 5: 43- AbstractObjective: We aimed to evaluate the clinical, demographic and laboratory features of alopecia areata (AA) patients who attended our policlinic in the last year. Material and Methods:The study was performed retrospectively and age, gender, family history of patients, onset age, duration and localization area of AA, number of recurrences, associated findings and laboratory findings were obtained from records. Results:The study included 132 patients. Median duration of disease was 4 months. 15.9% of the patients had a family history, 20.5% had another autoimmune disorder, 18% had nail findings, 18.5% atopy history. 6.5% of patients had nuchal nevus flammeus. Multifocal involvement was significantly higher in males. Positive correlation was detected between duration and severity of disease. The duration of disease was statistically related with increased thyroid autoantibodies. Nuchal nevus flammeus was related with total/universal AA. Low levels of iron, ferritin and hemoglobin were detected in approximately 10% of the patients. Conclusion: Our study is one of the studies investigating the largest parameters in AA patients. Our results indicate that there is a male dominance in AA and multifocal involvement is common in men. While early onset of disease, association with atopy and autoimmune disorder does not affect prognosis, antithyroid antibody positivity and association with nevus flammeus might be indicators of poorer prognosis. (Turk J Dermatol 2011; 5: 43-7)

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The Association between Nuchal Nevus Flammeus and Alopecia Areata: A Case-Control Study

Cited by 14 publications

References 25 publications

An investigation of poor prognostic factors in patients with alopecia areata and their relatives

An investigation of poor prognostic factors in patients with alopecia areata and their relatives

Alopesi areatada nukal nevüs flammeus sıklığı

Retrospective Evaluation of Alopecia Areata Patients

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