NT-ProBNP and cardiac troponin I in virulent canine babesiosis

Lobetti, Remo; Kirberger, Robert M.; Keller, Ninette; Kettner, Frank; Dvir, Eran

doi:10.1016/j.vetpar.2012.07.021

Cited by 16 publications

(17 citation statements)

References 38 publications

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“…Our observations, similarly to the results presented by Lobetti et al (2012), demonstrated that the troponin I level is not related to the haematocrit level. In 7 dogs in this study, the troponin I level was exceeded and the haematocrit level was normal.…”

Section: Discussionsupporting

confidence: 93%

“…anaemia, hypoxia or uraemia, and the heart muscle damage cannot be determined solely based on ECG result (Lobetti et al 2012). Nevertheless, in animals with protozoa infection, in which there is an irregular rhythm, the prognosis is poor (Dviret al 2004).…”

Section: Discussionmentioning

confidence: 99%

“…In this study, in order to confirm heart muscle damage, the serum troponin I (cTnI) level was measured, as well as the creatine kinase isoenzyme (CK-MB) level, which are the markers of myocardium damage (Schoberet al 1999, Boswood et al 2009, Lobetti 2012.…”

Section: Discussionmentioning

confidence: 99%

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Cardiac disorders in dogs infected with Babesia canis

Bartnicki¹,

Łyp²,

Dębiak³

et al. 2017

Polish Journal of Veterinary Sciences

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The aim of this study was to assess cardiac disorders in dogs infected with B. canis. The study included 50 dogs with babesiosis and 20 healthy control animals. All the animals had haematological tests, ECG, echocardiography and serum troponin I and CK-MB levels checked. The haematology in the group of dogs with babesiosis confirmed thrombocytopaenia in 100% of dogs, decreased haematocrit in 52% and anaemia in 46%. The most common abnormalities in ECG and echocardiography in dogs infected with protozoa included: change in appearance and/or amplitude of the T-wave (34%), increased fractional shortening (24%), an increased sinus rhythm (14%) and heart axis deviation (10%). In 19 of the 50 dogs with babesiosis, the level of serum troponin I was elevated. In 2 dogs that died from babesiosis, the troponin level I was very high. The ECG confirmed sinus tachycardia and interpolated ventricular beat in these animals. In all dogs with babesiosis that were used in the study, the serum CK-MB was high or very high and was within limits of 23.17 U/L -369.62 U/L. The highest kinase concentration (367.33 U/L and 369.62 U/L) was observed in dogs that died due to the disease. The presented results prove that cardiac changes are common in canine babesiosis, but that most changes are nonspecific and appear to have little clinical significance. Cardiovascular assessment should be based on the assessment of the level of troponin I and CK-MB in the serum of sick animals. High concentrations of these factors might be indicators of poor prognosis.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Cardiac disorders in dogs infected with Babesia canis

Bartnicki¹,

Łyp²,

Dębiak³

et al. 2017

Polish Journal of Veterinary Sciences

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“…Interestingly, there is a trend of increase in the blood concentration of such biomarker as the animals' clinical scenario worsened. A similar finding was reported by Lobetti et al (2012), who investigated the serum concentrations of NT-proBNP and cTnI in 45 dogs with babesiosis. In that study, the concentration of the biomarkers increased along with the severity of the disease.…”

Section: Resultssupporting

confidence: 85%

Cardiac biomarkers in dogs with visceral leishmaniasis

et al. 2016

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ABSTRACT.Although only a few studies have focused on the cardiac alterations in Leishmania spp. infected dogs, myocardial inflammation ascribed to such parasite has been documented in some animals. In spite of the increasing popularity of cardiac biomarkers in veterinary medicine in recent years, it remains unknown how most of these substances would perform in dogs with visceral leishmaniasis. In this study, we hypothesised that Leishmania spp. would damage cardiac myofibers resulting in increased circulating levels of cardiac specific markers in dogs. Therefore, biomarkers of myocyte injury and stress were investigated in 18 dogs with naturally-occurring visceral leishmaniasis presenting varying clinical signs, including completely asymptomatic animals. The median (min-max) concentrations of NT-proANP, NT-proBNP, cTnI, and CK-MB were 1138.0 (875-1175) pmol/L, 1160.0 (803-2034) fmol/L, 0.22 (0.15-0.51) ng/mL, and 116.7 (113-222) U/L, respectively. No differences were documented for the concentration of the natriuretic peptides and CK-MB in accordance with the severity of clinical signs, but for cTnI a significant difference was reported when comparing asymptomatic and symptomatic animals. Also, the compromise of renal tubular function seemed to interfere with the concentration of the natriuretic peptides and cTnI. In conclusion, all cardiac-specific biomarkers were elevated when compared to the normal range previously proposed for dogs. Measuring specific cardiac biomarkers has the potential to non-invasively document myocardial injuries attributable to visceral leishmaniasis.Key words: parasitic disease, myocarditis, natriuretic peptides, troponins. RESUMEN.A pesar de que solo unos pocos estudios se han centrado en las alteraciones cardíacas en perros infectados por la Leishmania spp., la inflamación miocárdica atribuida a este parásito ha sido documentada en algunos animales. Los marcadores cardiacos en medicina veterinaria han experimentado una creciente popularidad en los últimos años, sin embargo aún no se sabe cómo la mayoría de estas substancias se comporta en perros con leishmaniasis visceral. En este estudio, se presume que Leishmania spp. dañaría fibras cardiacas causando un aumento de los niveles circulantes de marcadores cardiacos en perros. Biomarcadores de lesión y de estrés de los miocitos fueron investigados en 18 perros con infección natural por Leishmania spp. y que presentaban diversos signos clínicos, incluyendo los animales totalmente asintomáticos. La mediana (mín-máx) de las concentraciones de NT-proANP, NT-proBNP, cTnI, CK-MB fueron 1138,0 (875-1175) pmol/L, 1160,0 (803-2034) fmol/L, 0,22 (0,15 -0,51) ng/mL y 116,7 (113-222) U/L, respectivamente. No se registraron diferencias para la concentración de los péptidos natriuréticos y CK-MB de conformidad con la gravedad de los síntomas clínicos, pero para la cTnI se observó diferencia significativa al comparar los animales sintomáticos y asintomáticos. Además, el compromiso de función tubular renal parece interferir con la concentración de los...

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“…Several noncardiac diseases can lead to secondary myocardial injury, which accentuates the importance of monitoring cardiac function. Myocardial injury can be detected by measuring cardiac troponin I (cTnI) or cardiac troponin T (cTnT) concentrations, and has been reported in dogs with gastric dilatation volvulus (GDV),4, 6 ehrlichiosis,8, 9 babesiosis,10, 11, 12 leishmaniasis,13 pyometra,14, 15 snake envenomation,16 kidney diseases,17, 18 noncardiac causes of respiratory distress,19 and canine parvovirosis 20…”

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confidence: 99%

Serum Cardiac Troponin I Concentrations in Dogs with Systemic Inflammatory Response Syndrome

Hamacher¹,

Dörfelt²,

Müller³

et al. 2015

Veterinary Internal Medicne

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BackgroundMyocardial injury can be detected by cardiac troponin I (cTnI) concentration, which appears to be a predictor of short‐term death in critically ill patients. It is unknown if the best prognostic indicator of short‐term survival is cTnI measurement at admission or at later time points.Hypothesis/ObjectivesMeasuring cTnI with a high‐sensitivity (HS) test at different time points after admission may be a better short‐term prognostic indicator than a single cTnI measurement at admission in dogs with systemic inflammatory response syndrome (SIRS).AnimalsProspective, observational clinical study of 60 dogs with SIRS.MethodsCardiac troponin I concentration was measured in 133 serum samples, collected at days 1, 2, 3, and 5. Additionally, the acute patient physiologic and laboratory evaluation (APPLE) fast score was evaluated at admission. Prognostic capabilities of cTnI measurement and APPLE fast score for 28‐day mortality were assessed by receiver operating characteristic curve analysis.ResultsForty‐one dogs with SIRS that survived 28 days had significantly lower serum cTnI concentrations at admission (median, 0.09 ng/mL; P = .004) and at the peak time point (median, 0.23 ng/mL; P = .01) compared to 19 nonsurvivors (median at admission, 0.63 ng/mL; median at peak, 1.22 ng/mL). Area under the curve to predict survival, using cTnI was similar at admission (0.732) and at peak (0.708), and was 0.754 for the APPLE fast score.Conclusions and Clinical ImportanceIncreased cTnI concentration in dogs with SIRS is associated with poor outcome. Daily follow‐up measurement of cTnI concentration provides no additional prognostic information for short‐term mortality.

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NT-ProBNP and cardiac troponin I in virulent canine babesiosis

Cited by 16 publications

References 38 publications

Cardiac disorders in dogs infected with Babesia canis

Cardiac disorders in dogs infected with Babesia canis

Cardiac biomarkers in dogs with visceral leishmaniasis

Serum Cardiac Troponin I Concentrations in Dogs with Systemic Inflammatory Response Syndrome

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