NSAID is inversely associated with asymptomatic gastric ulcer: Local health examination data from the Korean National Health Insurance Corporation

Kim, Hee Man; Cho, Jae Hee; Choi, Jin Yi; Chun, Song Wook; Kim, Yu Jin; Cho, Hyun‐Jong; Song, Si Young; Han, Ki Jun

doi:10.3109/00365521.2013.838606

Cited by 7 publications

(8 citation statements)

References 20 publications

(29 reference statements)

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“…Third, although it typically requires an endoscopic confirmation, PUD was determined based on a previous diagnosis by a physician in this study. The incidence of endoscopically confirmed PUD in Korea has been reported to be 2.45–7.0% [ 25 – 27 ] which was consistent with our results. Also, as the lifetime screening rate for stomach cancer during the study period was about 65%, we believe that the majority of subjects in this study had been diagnosed with PUD by endoscopy.…”

Section: Discussionsupporting

confidence: 92%

The association between peptic ulcer diseases and mental health problems

Lee

Yu²,

Choi³

et al. 2017

Medicine

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This study aimed to investigate the association between the prevalence of peptic ulcer disease (PUD) and mental health problems, such as severe stress, depressive mood, and suicidal ideation.The population-based cross-sectional study was comprised of 14,266 subjects participating in the fourth annual Korea National Health and Nutrition Examination survey from 2007 to 2009. The participants were divided into 2 groups according to the self-reported questionnaires: the PUD group and the non-PUD group. The association between PUD and mental health problems, such as severe stress, depressed mood, suicidal ideation, and psychological counseling history, were evaluated by using multivariate analysis and logistic regression.Among the 14,266 participants over 19-years old, 813 participants (5.6%) had PUD. Compared to the non-PUD group (n = 13,453), the PUD group had a significantly higher percentage of males, current smokers, and heavy drinkers, lower education status, lower income, and greater presence of diabetes mellitus, hypertension, metabolic syndrome and mental health problems, including severe stress, depressed mood, suicidal ideation, and psychological counseling history. After adjustment for lifestyle and medical and environmental factors, mental health problems were found to be associated with a significantly higher risk for PUD.Psychological problems, such as severe stress, depressed mood, suicidal ideation, and psychological counseling, were associated with PUD prevalence.

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Section: Discussionsupporting

confidence: 92%

The association between peptic ulcer diseases and mental health problems

Lee

Yu²,

Choi³

et al. 2017

Medicine

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“…PUD requires endoscopic confirmation, which suggests that some of the subjects in our study may not have had PUD. However, the incidence of endoscopically confirmed PUD has been reported to be between 2–10% in Korea, which suggests that our study may not have overestimated PUD incidence34353637. Also, as the lifetime screening rate for stomach cancer during the study period was about 65%, we believe that many of our subjects had been diagnosed with PUD by endoscopy38.…”

Section: Discussionmentioning

confidence: 67%

Women Who Sleep More Have Reduced Risk of Peptic Ulcer Disease; Korean National Health and Nutrition Examination Survey (2008–2009)

Baeg

et al. 2016

Sci Rep

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Sleep is integral to life and sleep duration is important in sleep quality, physical, and psychological health. Disturbances in sleep duration have been associated with increased risk of metabolic disorders, hypertension, and overall mortality. Sleep disturbance has also been linked with various gastrointestinal disorders. However, the association between sleep and peptic ulcer disease (PUD) has not been evaluated. We investigated the association between sleep duration and PUD. Subjects were included from the fifth Korean National Health and Nutrition Examination Survey conducted from 2008–2009. Individuals with PUD were defined as those with a physician diagnosis of PUD. Daily sleep duration was established by asking participants the amount of time that they slept per day. Multiple logistic regression models were used to evaluate the association of PUD and sleep duration. This study included 14,290 participants (8,209 women). The prevalence of PUD was 5.7% and was higher in men (6.8%) than in women (4.9%). Women who slept ≥9 hours were significantly less likely to have PUD compared to women who slept 7 hours. In men, longer sleep duration (≥9 hours) had a tendency toward PUD prevention. Our results suggest that longer sleep duration may play a protective role for PUD development.

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“…The main action mechanism of NSAIDs damaging on the stomach and duodenum mucous membrane is its cyclooxygenase (COX) enzyme blockade, which has two isomers: block COX-1 and COX-2 induced [4,5,7]. Inhibition of COX-1 activity, while taking NSAIDs, causes depression of prostaglandin synthesis system, which serves as the main cause of such side effects as gastroduodenal erosive and ulcerative lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Inhibition of COX-1 activity, while taking NSAIDs, causes depression of prostaglandin synthesis system, which serves as the main cause of such side effects as gastroduodenal erosive and ulcerative lesions. It deplets the stocks in the tissues and causes iatrogenic prostaglandins failure [3,5].…”

Section: Discussionmentioning

confidence: 99%

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Plasma Levels of Leukotriene B4 and Prostaglandin E2 Correlation with Endoscopic Changes after NSAID Gastropathies Pantoprazole Treatment in Patients with Cardiovascular Pathology

Mbarki¹,

Sklyarova²,

Aksentiychuk³

et al. 2016

JPP

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Abstract:The article describes the pantoprazole healing effect on the gastroduodenal mucosa in patients with NSAID gastropathy. Two groups of patients were compared, depending on the treatment they have got group, which was taking 75 mg of enteric aspirin per day and the group, where pantoprazole has been added to aspirin in the usual dose. Mucosa assessment was studied using fibrogastroduodenoscopy and Lanza score. Also, the relationship between aggression factors that cause NSAID gastropathy and mucosal protection agents has been studied. It was proved that the pantoprazole influence reduces the ulcerative-erosive lesions amount. Stomach erosive lesions percentage decreased from 58.18% to 42.42%, stomach ulcers from 14.55% to 6.06%, duodenum erosive lesions decreased from 34.55% to 24.24%, duodenum ulcers deceased from 9.09% to 3.03%. A positive correlation between LTB4 and Lanza scale was checked after pantoprazole treatment, indicating an impact on the LTB4 reduction in ulcers healing in patients with NSAID gastropathy.

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NSAID is inversely associated with asymptomatic gastric ulcer: Local health examination data from the Korean National Health Insurance Corporation

Cited by 7 publications

References 20 publications

The association between peptic ulcer diseases and mental health problems

The association between peptic ulcer diseases and mental health problems

Women Who Sleep More Have Reduced Risk of Peptic Ulcer Disease; Korean National Health and Nutrition Examination Survey (2008–2009)

Plasma Levels of Leukotriene B4 and Prostaglandin E2 Correlation with Endoscopic Changes after NSAID Gastropathies Pantoprazole Treatment in Patients with Cardiovascular Pathology

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