Abstract:The article describes the pantoprazole healing effect on the gastroduodenal mucosa in patients with NSAID gastropathy. Two groups of patients were compared, depending on the treatment they have got group, which was taking 75 mg of enteric aspirin per day and the group, where pantoprazole has been added to aspirin in the usual dose. Mucosa assessment was studied using fibrogastroduodenoscopy and Lanza score. Also, the relationship between aggression factors that cause NSAID gastropathy and mucosal protection agents has been studied. It was proved that the pantoprazole influence reduces the ulcerative-erosive lesions amount. Stomach erosive lesions percentage decreased from 58.18% to 42.42%, stomach ulcers from 14.55% to 6.06%, duodenum erosive lesions decreased from 34.55% to 24.24%, duodenum ulcers deceased from 9.09% to 3.03%. A positive correlation between LTB4 and Lanza scale was checked after pantoprazole treatment, indicating an impact on the LTB4 reduction in ulcers healing in patients with NSAID gastropathy.
Abstract:The objective of this study was to investigate the pantoprazole and rebamipide efficiency on NSAIDs (nonsteroidal anti-inflammatory drugs)-gastropathy restoring and healing in patients with coronary heart disease, stable angina, who have been taking aspirin for a long time period. The study included three groups of patients according to the treatment they have got: ASA (acetylsalicylic acid) in the first group; ASA and pantoprazole in the second; ASA, pantoprazole and rebamipide in the third one. To obtain the results, endoscopic method and proinflammatory cytokines LTB4 and protective prostaglandin E2 determination in the blood were used. The research demonstrated no ulcer effects in the group of patients who were treated by rebamipide, and significantly fewer gastroduodenal erosions, in comparison to the group, where treatment contained ASA and pantoprazole. The LTB4 (leukotriene B4) level decreased in pantoprazole and rebamipide treatment groups, but the PGE2 (prostaglandin E2) level increased only after rebamipide therapy. Therefore, rebamipide should be included to the therapy for the better NSAIDs-gastropathy treatment, in reason of its good reparative and gastroprotective properties.
Львівський національний медичний університет імені Данила ГалицькогоРезюме. Проведена оцінка ролі лейкотриєну B4 (LTB4) та простагландину Е2 (PgE2) у розвитку НПЗПгастропатій на тлі призначення інгібіторів протонної помпи. Встановлено, що призначення нестероїдних протизапальних препаратів у профілактичній дозі хворим із кардіоваскулярною патологією призводить до пригнічення циклооксигенази, зміщаючи рівновагу між PgE2 та LTB4 на користь останніх із подальшим розвитком НПЗП-гастропатій. Застосування пантопразолу призводило до зменшення ерозивно-виразкових уражень гастродуоденальної зони на тлі прийому ацетилсаліцилової кислоти (АСК). Крім того, призначення пантопразолу призводило до суттєвого зниження показників LTB4 без достовірних змін вмісту PgE2, що необхідно враховувати для подальшої корекції лікування таких осіб.
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