The association between peptic ulcer diseases and mental health problems

Abstract

This study aimed to investigate the association between the prevalence of peptic ulcer disease (PUD) and mental health problems, such as severe stress, depressive mood, and suicidal ideation.The population-based cross-sectional study was comprised of 14,266 subjects participating in the fourth annual Korea National Health and Nutrition Examination survey from 2007 to 2009. The participants were divided into 2 groups according to the self-reported questionnaires: the PUD group and the non-PUD group. The association between PUD and mental health problems, such as severe stress, depressed mood, suicidal ideation, and psychological counseling history, were evaluated by using multivariate analysis and logistic regression.Among the 14,266 participants over 19-years old, 813 participants (5.6%) had PUD. Compared to the non-PUD group (n = 13,453), the PUD group had a significantly higher percentage of males, current smokers, and heavy drinkers, lower education status, lower income, and greater presence of diabetes mellitus, hypertension, metabolic syndrome and mental health problems, including severe stress, depressed mood, suicidal ideation, and psychological counseling history. After adjustment for lifestyle and medical and environmental factors, mental health problems were found to be associated with a significantly higher risk for PUD.Psychological problems, such as severe stress, depressed mood, suicidal ideation, and psychological counseling, were associated with PUD prevalence.

Reciprocal association between depression and peptic ulcers: Two longitudinal follow-up studies using a national sample cohort

“…In addition, this study used control groups matched for demographic factors, and past medical histories were rigorously adjusted using the CCI. The previous studies also mentioned an association between depression and peptic ulcers 5,9,15 . A nationwide cohort study described that the depression patients had 1.35 times higher risk of peptic ulcer (95% CI = 1.29-1.42) 5 .…”

“…A nationwide cohort study described that the depression patients had 1.35 times higher risk of peptic ulcer (95% CI = 1.29-1.42) 5 . Another cross-sectional study reported elevated odds of depression in peptic ulcer patients 9 . However, neither study matched the control group for the income and region of residence.…”

“…Because both depression and peptic ulcers are related to the income and region of residence, these factors should be even between the study and control groups 16,17 . In addition, causality could not be concluded due to a cross-sectional study design 9 . In contrast, a cross-sectional study described no relation between depression and peptic ulcer disease 15 .…”

Anxiolytic Effects of Acanthopanax senticosus HARMS Occur via Regulation of Autonomic Function and Activate Hippocampal BDNF–TrkB Signaling

“…On the other hand, stress-induced gastric ulcers develop because of stress and its associated anxiety [46]. This mental anxiety is known to increase SNS activity, while decreasing PNS activity [32].…”

“…Next, we examined the effects of ASH on novel environmental stress and high-fear stress. It is known that environmental factors, such as increased fear of heights, activate the SNS and inhibit the PNS, resulting in various anxiety-related behaviors and impaired physical condition [46,48,49]. In addition, patients suffering from anxiety disorders have excessive SNS activity and PNS inactivation, and similar symptoms are observed even in rodents [31,32,33].…”