NSAID-gastroenteropathy: new aspects of pathogenesis and prevention

Blackler, Rory W.; Gemici, Burcu; Mańko, Anna; Wallace, John L.

doi:10.1016/j.coph.2014.05.008

Cited by 65 publications

(69 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the use of these medicines is frequently related with disorders on gastric mucosa, as well as on the renal and cardiovascular systems (Harirforoosh et al 2013). Non-steroidal anti-inflammatory drugs are also an important group of drugs largely utilized in the treatment of inflammatory diseases, acting by inhibition of the cyclooxygenase and then prevent the conversion of arachidonic acid to prostaglandins (Blackler et al 2014). Nevertheless, these drugs have some limitations and cannot regulate the production of leukotrienes or PAF that continues to cause inflammation.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and anti-proliferative activities of the wild edible cruciferous:Diplotaxis simplex

Jdir

Khemakham

Najjaa

et al. 2016

Pharmaceutical Biology

View full text Add to dashboard Cite

Context The present study deals with new biological properties of the wild edible Diplotaxis simplex (Viv.) Spreng (Brassicaceae). Objectives The current study evaluates the antioxidant, the anti-inflammatory and the anti-cancer properties of ethyl acetate and ethanol extracts from D. simplex flowers. Materials and methods The anti-proliferative activity of the extracts (10-70 mg/mL) was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) against human colon cancer cell line Caco-2. The anti-inflammatory potential was evaluated by the inhibitory effect of the extracts (1.5-7.5 mg/mL) on phospholipase A2 activity as well as on carrageenan-induced paw oedema in mice. Extracts (200 mg/kg) or indomethacin (50 mg/kg) as positive control were injected intraperitoneally for albino mice prior to the induction of the oedema by carrageenan. Antioxidant activities were investigated using various complementary methods.Results Flower extracts contained a high level of polyphenolics (17.10-52.70 mg GAE/g) and flavonoids (74.20-100.60 mg QE/g), which correlate with its appreciable antioxidant potential in b-carotene peroxidation (IC 50 value: 12.50-27.10 mg/mL), DPPH radical-scavenging (IC 50 value: 0.20-0.40 mg/mL), Fe 3+ reducing (EC 50 value: 0.10-0.14 mg/mL) and Fe 2+ chelating (IC 50 value: 0.20-0.60 mg/mL) assays. These extracts were effective in inhibiting cancer cell growth (IC 50 value: 62.0-63.25 mg/mL). Besides, the ethyl acetate extract inhibited phospholipase A2 activity (IC 50 value: 2.97 mg/mL) and reduced the paw oedema in mice (from 0.38 ± 0.01 to 0.24 ± 0.01 cm), 4 h postcarrageenan challenge. Conclusion These data suggest that D. simplex may be useful as a candidate in the treatment of inflammation and the colon cancer.ARTICLE HISTORY

show abstract

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and anti-proliferative activities of the wild edible cruciferous:Diplotaxis simplex

Jdir

Khemakham

Najjaa

et al. 2016

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…In 2011, we reported that in rodents, suppression of acid secretion with PPIs, although effective at preventing gastroduodenal damage, resulted in a dramatic worsening of distal intestinal damage [13]. This was confirmed by others, and was shown to occur also with histamine H 2 receptor antagonists [14][15][16]. Moreover, there is clinical evidence linking use of PPIs and H 2 receptor antagonists to severe intestinal damage observed in rheumatoid arthritis patients taking NSAIDs [8].…”

mentioning

confidence: 53%

NSAID enteropathy and bacteria: a complicated relationship

et al. 2015

View full text Add to dashboard Cite

The clinical significance of small intestinal damage caused by nonsteroidal anti-inflammatory drugs (NSAIDs) remains under-appreciated. It occurs with greater frequency than the damage caused by these drugs in the upper gastrointestinal tract, but is much more difficult to diagnose and treat. Although the pathogenesis of NSAID enteropathy remains incompletely understood, it is clear that bacteria, bile, and the enterohepatic circulation of NSAIDs are all important factors. However, they are also interrelated with one another. Bacterial enzymes can affect the cytotoxicity of bile and are essential for enterohepatic circulation of NSAIDs. Gram-negative bacteria appear to be particularly important in the pathogenesis of NSAID enteropathy, possibly through release of endotoxin. Inhibitors of gastric acid secretion significantly aggravate NSAID enteropathy, and this effect is due to significant changes in the intestinal microbiome. Treatment with antibiotics can, in some circumstances, reduce the severity of NSAID enteropathy, but published results are inconsistent. Specific antibiotic-induced changes in the microbiota have not been causally linked to prevention of intestinal damage. Treatment with probiotics, particularly Bifidobacterium, Lactobacillus, and Faecalibacteriaum prausnitzii, has shown promising effects in animal models. Our studies suggest that these beneficial effects are due to colonization by the bacteria, rather than to products released by the bacteria.

show abstract

“…Roth, употреб-ляют для обозначения патологии желудка и две-надцатиперстной кишки, связанной с приемом НПВП и диагностируемой при наличии поврежде-ния слизистой оболочки гастродуоденальной зоны с формированием эрозий и язв, а также их ослож-нений (кровотечения, перфорация, нарушение про-ходимости и др.). Согласно действующей на се-годня Международной классификации болезней 10-го пересмотра (1993) эти осложнения обознача-ются «НПВП-гастропатия: язва желудка, осложнен-ная кровотечением» или другие эрозивно-язвенные поражения гастродуоденальной зоны (Y 45.8, K 25, K 92) [15,18,23,41,47].…”

Section: Aadsorasunclassified

Preventive and therapeutic strategies of pharmaco-correction gastropathy induced by nonsteroidal anti-inflammatory drugs

Hladkykh

2017

Rev Clin Pharm Drug Ther

View full text Add to dashboard Cite

Today the problem of prevention and treatment of gastropathy associated with nonsteroidal anti-inflammatory drugs has not lost its relevance. In order to reduce the ulcerogenicity of non-steroidal anti-inflammatory drugs, it is classically accepted to supplement the therapy scheme with preparations of other pharmacological groups - antacids, alginates, M-cholinoblockers, gastrin receptor antagonists, H2-histamine blockers, proton pump inhibitors, synthetic analogues of prostaglandins or stimulators of their synthesis, reparants, gastroprotectors. Nowadays, it was suggested I was suggested the use of drugs which have pharmacological properties polyvector (vinboron, thiotriazoline et al.). Also, the scientists started of combined preparations “NSAIDs + drugs other pharmacological groups” - indotril (indomethacin + thiotriazoline) diklokor (diclofenac + quercetin) Artrotek (diclofenac sodium + misoprostol) dueksis (ibuprofen + famotidine) vimovo (naproxen + esomeprazole) aksorid (ketoprofen + omeprazole) tioaspekard (thiotriazoline + ACK) aspifat (ACK + sucralfate), Alka-Zelttser® (ACK + sodium bicarbonate), and others. The second direction is preventing and improving NSAID gastrotoxicity protrudes improving existing non-steroidal drugs - modification of gaseous molecules (NO, H2S, CO), amino acid derivatives, modulators “effector function” of afferent terminals n. vagus (amtolmetina guatsil) то pairing with nanoparticles biometals (Zn-ibuprofen, Zn-naproxen, Zn-indomethacin). (For citation: Hladkykh FV. Preventive and therapeutic strategies of pharmaco-correction gastropathy induced by nonsteroidal anti-inflammatory drugs. Reviews on Clinical Pharmacology and Drug Therapy. 2017;15(4):14-23. doi: 10.17816/RCF15414-23).

show abstract

NSAID-gastroenteropathy: new aspects of pathogenesis and prevention

Cited by 65 publications

References 33 publications

Anti-inflammatory and anti-proliferative activities of the wild edible cruciferous:Diplotaxis simplex

Anti-inflammatory and anti-proliferative activities of the wild edible cruciferous:Diplotaxis simplex

NSAID enteropathy and bacteria: a complicated relationship

Preventive and therapeutic strategies of pharmaco-correction gastropathy induced by nonsteroidal anti-inflammatory drugs

Contact Info

Product

Resources

About