Novel ultrafine‐grained β‐type Ti–28Nb–2Zr–8Sn alloy for biomedical applications

Abstract

Titanium alloys are widely accepted as orthopedic or dental implant materials in the medical field. It is important to evaluate the biocompatibility of an implant material prior to use. A new β‐type ultrafine‐grained Ti–28Nb–2Zr–8Sn (TNZS) alloy with low Young's modulus of 31.6 GPa was fabricated. This study aims to evaluate the biocompatibility of TNZS alloy. In this study, we examined the microstructure, chemical composition and surface wettability of the TNZS alloy. The mouse embryonic osteoblast MC3T3‐E1 cells and human umbilical vein endothelial cells (HUVECs) were cultured to study the cytocompatibility of TNZS alloy. Also, we evaluated the proinflammatory response of TNZS alloy in vitro and in vivo. The results show that the TNZS did not cause cytotoxicity, genotoxicity to MC3T3‐E1 cells and HUVECs. Whereas, the TNZS alloy could significantly promote the cell proliferation, cell spreading and cell adhesion of MC3T3‐E1 cells and HUVECs, as well as facilitate the osteogenic differentiation of MC3T3‐E1 cells. Moreover, the TNZS alloy did not induce any remarkable proinflammatory response in vitro and in vivo. Thus, the novel TNZS alloy with an elasticity closer to that of human bone is biologically safe and could be a potential candidate for biomedical implant application. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1628–1639, 2019.

Novel Bionic Topography with MiR-21 Coating for Improving Bone-Implant Integration through Regulating Cell Adhesion and Angiogenesis

“…With the accelerating trend of population aging, there is a growing demand for implants. Having the advantages of good biocompatibility, high corrosion resistance, and superior mechanical properties, titanium (Ti) and its alloys have been widely used in the orthopedics field. − However, Ti-based implants are known to be bioinert, which usually causes poor osseointegration after implantation (clinically called the “loosening” phenomenon) and finally leads to a surgery’s unsatisfactory success rate. − As it is well-known, material surface physicochemical characteristics affect cellular behaviors. , A desirable implant must possess a surface that favors osteoblast adhesion, spreading, proliferation, and differentiation. , Therefore, surface modification of titanium to improve surface bioactivity and ultimately meet clinical needs is still the focus of current research.…”