“…Accordingly, expression of SUR1 is up-regulated in reactive astrocytes, neurons, and capillaries of rodent models for ischemia, traumatic brain injury, and spinal cord injury (11,12,(43)(44)(45). The effects of trauma appear to be reduced by administration of glibenclamide (46,47); clinical trials to test the potential of this antidiabetic drug as a treatment for brain edema are under way (48), but the subject remains controversial (49,50). On the other hand, fragmentation and hemorrhaging in capillaries correlate with an increase in TRPM4 expression in rats after spinal cord injury and are significantly mitigated in TRPM4-null mice (17).…”