Novel topical formulations of Terbinafine-HCl for treatment of onychomycosis

Tanrıverdi, Sakine Tuncay; Özer, Özgen

doi:10.1016/j.ejps.2012.12.014

Cited by 81 publications

(52 citation statements)

References 62 publications

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“…Worthy to note that there were two successful attempts for the use of vesicles in the topical treatment of onychomycosis using transfersomal, liposomal and ethosomal terbinafine (Sigurgeirsson & Ghannoum, 2012;Tanriverdi & Ozer, 2013). Our findings confirm that nail penetration enhancer containing nanovesicles (nPEVs) present a very promising ungual delivery system, worthy of clinical experimentation on onychomycotic patients.…”

Section: Microbiological Efficacy Of Npevs For the Treatment Of Onychsupporting

confidence: 75%

Novel nail penetration enhancer containing vesicles “nPEVs” for treatment of onychomycosis

et al. 2015

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Context: The systemic treatment of onychomycosis has been hampered by the reported side effects of antifungals in addition to the limited blood circulation to the affected nails. Topical ungual treatment would circumvent the limitations of systemic onychomycosis treatment. Objective: Preparation and characterization of nail penetration enhancer containing nanovesicles (nPEVs) loaded with sertaconazole for topical treatment of onychomycosis. Materials and methods: nPEVs were prepared using different nail penetration enhancers (N-acetyl-L-cysteine, thioglycolic acid, thiourea and ethanol) by the thin film hydration method, and characterized for their particle size, zeta potential, entrapment efficiency (EE%), elasticity, viscosity, physical stability and morphology. The selected nPEVs formula and the marketed Dermofix Õ cream were compared in terms of nail hydration, transungual drug uptake and antifungal activity against Trichophyton rubrum. Results: N-acetyl-L-cysteine was the optimum nail penetration enhancer for incorporation within vesicles. nPEVs showed high EE% of sertaconazole ranging from 77 to 95%, a size ranging from 38-538 nm and a zeta potential ranging from +48 to +72 mV. The selected nPEVs formula displayed spherical morphology and good storage stability. Compared to the conventional marketed cream, the selected nPEVs formula showed 1.4-folds higher hydration and drug uptake enhancement into nail clippings. Furthermore, it showed significantly higher zone of inhibition for Trichophyton rubrum (20.9 ± 0.25 mm) than the marketed cream (11.6 ± 0.44 mm). Conclusion: Nail penetration enhancer containing nanovesicles (nPEVs) present a very promising option, worthy of clinical experimentation on onychomycotic patients.

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Section: Microbiological Efficacy Of Npevs For the Treatment Of Onychsupporting

confidence: 75%

Novel nail penetration enhancer containing vesicles “nPEVs” for treatment of onychomycosis

et al. 2015

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“…Species most commonly isolated from patients with onychomycosis around the world are the dermatophytes, Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis, Microsporum gypseum, and Epidermophyton floccosum [2,5,10,11].…”

Section: Introductionmentioning

confidence: 99%

<i>In vitro</i> Antifungal Activity of <i>Baccharis trimera</i> Less (DC) Essential Oil against Dermatophytes

Caneschi¹,

Martins²,

Larrudé³

et al. 2015

Trop. J. Pharm Res

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“…Attempts to compensate the loss of drug owing to such factors may increase the risk of dose related adverse effects. Hence, topical administration is a more practical approach which would result into much lower, often undetectable systemic levels, thus reducing possible toxicity of the drug [8][9][10].…”

Section: Slns Based On Co-processed Lipids For Topical Delivery Of Tementioning

confidence: 99%

SLNs Based on Co-Processed Lipids for Topical Delivery of Terbinafine Hydrochloride

Tiwari¹,

Mistry²,

Patel³

2014

Journal of Pharmaceutics and Drug Development

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Novel topical formulations of Terbinafine-HCl for treatment of onychomycosis

Cited by 81 publications

References 62 publications

Novel nail penetration enhancer containing vesicles “nPEVs” for treatment of onychomycosis

Novel nail penetration enhancer containing vesicles “nPEVs” for treatment of onychomycosis

<i>In vitro</i> Antifungal Activity of <i>Baccharis trimera</i> Less (DC) Essential Oil against Dermatophytes

SLNs Based on Co-Processed Lipids for Topical Delivery of Terbinafine Hydrochloride

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