Novel thymoquinone loaded chitosan-lecithin micelles for effective wound healing: Development, characterization, and preclinical evaluation

Negi, Poonam; Sharma, Gulshan B.; Verma, Chetna; Garg, Pratibha; Rathore, Charul; Kulshrestha, Saurabh; Lal, Uma Ranjan; Gupta, Bhuvanesh; Pathania, Deepak

doi:10.1016/j.carbpol.2019.115659

Cited by 42 publications

(26 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Here, in our case, negative zeta potential plays a crucial role in LAE. [15,16,48]. Here, TMQ-NEG was formulated to enhance the wound healing effects of TMQ through the NEG system.…”

Section: Ex-vivo Skin Permeabilitymentioning

confidence: 99%

“…Taking the consideration of properties mentioned above, Selcuk et al (2013) studied the wound healing activity of TMQ in the rat model [15]. The wound healing properties of TMQ have been attributed due to its anti-microbial, resistance-modifying, anti-oxidant, and anti-inflammatory properties [5][6][7][8][9][10]16]. The therapeutic application of TMQ, as a woundhealing agent, has resulted in an enhanced anti-inflammatory response, diminished oxidative stress, better fibroblast formation, increased granular tissue production, augmented wound contraction, and re-epithelization [15,16].…”

Section: Introductionmentioning

confidence: 99%

“…The wound healing properties of TMQ have been attributed due to its anti-microbial, resistance-modifying, anti-oxidant, and anti-inflammatory properties [5][6][7][8][9][10]16]. The therapeutic application of TMQ, as a woundhealing agent, has resulted in an enhanced anti-inflammatory response, diminished oxidative stress, better fibroblast formation, increased granular tissue production, augmented wound contraction, and re-epithelization [15,16]. The topical application of TMQ in wound healing is an effective approach as it offers direct access to the affected sites [17].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Thymoquinone Loaded Topical Nanoemulgel for Wound Healing: Formulation Design and In-Vivo Evaluation

et al. 2021

View full text Add to dashboard Cite

Thymoquinone is a natural bioactive with significant therapeutic activity against multiple ailments including wound healing. The poor aqueous solubility and low skin permeability limit its therapeutic efficacy. The present investigation aimed to improve the biopharmaceutical attributes of thymoquinone to enhance its topical efficacy in wound healing. A nanoemulsion-based hydrogel system was designed and characterized as a nanotechnology-mediated drug delivery approach to improve the therapeutic efficacy of thymoquinone, utilizing a high-energy emulsification technique. The black seed oil, as a natural home of thymoquinone, was utilized to improve the drug loading capacity of the developed nanoemulsion system and reduced the oil droplet size to <100 nm through ultrasonication. The influence of formulation composition, and the ultrasonication process conditions, were investigated on the mean globule size and polydispersity index of the generated nanoemulsion. Irrespective of surfactant/co-surfactant ratio and % concentration of surfactant/co-surfactant mixture, the ultrasonication time had a significant (p < 0.05) influence on the mean droplet size and polydispersity index of the generated nanoemulsion. The developed nanoemulgel system of thymoquinone demonstrated the pseudoplastic behavior with thixotropic properties, and this behavior is desirable for topical application. The nanoemulgel system of thymoquinone exhibited significant enhancement (p < 0.05) in skin penetrability and deposition characteristics after topical administration compared to the conventional hydrogel system. The developed nanoemulgel system of thymoquinone exhibited quicker and early healing in wounded Wistar rats compared to the conventional hydrogel of thymoquinone, while showing comparable healing efficacy with respect to marketed silver sulfadiazine (1%) cream. Furthermore, histopathology analysis of animals treated with a developed formulation system demonstrated the formation of the thick epidermal layer, papillary dermis along with the presence of extensive and organized collagen fibers in newly healed tissues. The outcome of this investigation signifies that topical delivery of thymoquinone through nanoemulgel system is a promising candidate which accelerates the process of wound healing in preclinical study.

show abstract

“…Here, in our case, negative zeta potential plays a crucial role in LAE. [15,16,48]. Here, TMQ-NEG was formulated to enhance the wound healing effects of TMQ through the NEG system.…”

Section: Ex-vivo Skin Permeabilitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thymoquinone Loaded Topical Nanoemulgel for Wound Healing: Formulation Design and In-Vivo Evaluation

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The reason for this is related to the combination of the hydrogel's skin hydration with the skin penetration effect of the drug-loaded micelles with a small particle size. 18,19 Recently, we also prepared paclitaxel-loaded MPEG-ibuprofen conjugate micelles and encapsulated them into Carbopol 940 hydrogels. The results demonstrated the promotion effect of the combination of the drug-loaded micelles-in-hydrogels with Taxol on anti-B16 in vivo when compared with Taxol alone.…”

Section: Introductionmentioning

confidence: 99%

Carbopol 940 hydrogel containing curcumin-loaded micelles for skin delivery and application in inflammation treatment and wound healing

Song

Wen

Teng³

et al. 2022

New J. Chem.

View full text Add to dashboard Cite

show abstract

“…Хитозан является природным полисахаридом, построенным из звеньев остатков 2  амино-2  дезокси-D   глюкопиранозы, соединенных (1 4)     гликозидной связью. Биосовместимость, способность к биодеградации и наличие активных функциональных групп позволяет использовать хитозан в пищевой промышленности, косметологии, биомедицинских и синтетических целях, например, при микрокапсулировании веществ для пролонгации их действия [1,2], при получении пен [3], эмульсий [4,5], пленок [6], волокон [7], а также в качестве реологических модификаторов. Хорошо известно, что именно адсорбционные и реологические свойства ПАВ на границах раздела фаз играют важную роль в создании стабильных наноразмерных адсорбционных слоев на поверхности нано-, микрочастиц, капсул, капель эмульсий, оказывают существенное влияние на способность к пленко-и волокнообразованию, определяют физико-химические и физикомеханические свойства полимерных композиционных материалов.…”

Section: Introductionunclassified

Adsorption and Dilational Rheological Properties of Chitosan Lactate at the Liquid-Gas Interface

Kovtun¹

2020

Physical and Chemical Aspects of the Study of Clusters, Nanostructures and Nanomaterials

View full text Add to dashboard Cite

Методом формы осциллирующей капли исследованы адсорбционные и дилатационные реологические характеристики (модуль упругости и вязкости) лактата хитозана на границе раздела жидкость - газ. Определены зависимости динамического и равновесного поверхностного натяжения от концентрации лактата хитозана в растворе. Установлено, что полученные зависимости сходны с таковыми для поверхностноактивных высокомолекулярных соединений. Изучены зависимости поверхностных упругости и вязкости лактата хитозана от частоты осцилляций и концентрации. Показано, что лактат хитозана способен образовывать упругие адсорбционные слои со значениями модуля вязкоупругости сопоставимыми для биополимеров белковой природы. The adsorption and dilatational rheological characteristics (the elasticity and viscosity modulus) of chitosan lactate at the liquid-gas interface are investigated by the oscillating drop shape method. The dependences of the dynamic and equilibrium surface tension on the concentration of chitosan lactate in solution have been determined. It was found that the dependences obtained are similar to those for surface-active high-molecular weight compounds. The dependences of the surface elasticity and viscosity of chitosan lactate on the oscillation frequency and concentration have been studied. It has been shown that chitosan lactate is capable of forming elastic adsorption layers with the values of the viscoelastic modulus comparable to that of protein biopolymers.

show abstract

Novel thymoquinone loaded chitosan-lecithin micelles for effective wound healing: Development, characterization, and preclinical evaluation

Cited by 42 publications

References 39 publications

Thymoquinone Loaded Topical Nanoemulgel for Wound Healing: Formulation Design and In-Vivo Evaluation

Thymoquinone Loaded Topical Nanoemulgel for Wound Healing: Formulation Design and In-Vivo Evaluation

Carbopol 940 hydrogel containing curcumin-loaded micelles for skin delivery and application in inflammation treatment and wound healing

Adsorption and Dilational Rheological Properties of Chitosan Lactate at the Liquid-Gas Interface

Contact Info

Product

Resources

About