Carbopol 940 hydrogel containing curcumin-loaded micelles for skin delivery and application in inflammation treatment and wound healing

Abstract

Inflammation and excessive reactive oxygen species production are main reason for slow wound healing, which needs an efficient therapy in clinic. In the paper, curcumin-enveloped methoxy poly(ethylene glycol)-poly(-valerolactone)-poly(-caprolactone) (MPEG-PVL-PCL) micelles...

Carbopol 940-based hydrogels loading synergistic combination of quercetin and luteolin from the herb Euphorbia humifusa to promote Staphylococcus aureus infected wound healing

“…39 Numerous studies have demonstrated that the flavonoids and Carbopol 940 hydrogel possess wound-healing properties due to their well-acclaimed anti-inflammatory, antioxidant, re-epithelialization, and angiogenesis effects. 14,40–43 In our previous report, QU in combination with LU enhanced the antibacterial and antibiofilm efficacy synergistically, decreasing the membrane permeability and down-regulating the expression of multiple biofilm-related genes. 30 Besides, QU and LU are known for their powerful anti-inflammatory and antioxidant potency due to the resonance stability of the phenoxyl radical, 31,32 which support their potential use in wound healing.…”

“…13 Recently, the curcumin-loaded methoxy poly(ethylene glycol)-poly(delta-valerolactone)poly(epsilon-caprolactone) micelle-embedded Carbopol 940 hydrogel was demonstrated to be a potential candidate for the treatment of skin inflammation and full thickness wound healing. 14 Moreover, a few herbal plant extracts or purified active compounds formulated into Carbopol 940 hydrogel preparations have been used for wound healing. [15][16][17] Natural products have always been significant resources of alternatives of antibiotics against S. aureus.…”

Fibroblast-targeting polymeric nanovehicles to enhance topical wound healing through promotion of PAR-2 receptor-mediated endocytosis

“…As the KTTKS has a cysteamine group at the C-terminus, it can be covalently patched on the MEL linker co-assembled with PNVs through a thiol-maleimide reaction. Curcumin was selected as a model active ingredient that can accelerate fibroblast proliferation 33,34 and was encapsulated in the core, thus producing CPNV KTTKS (Fig. 1a).…”

Antioxidant, hemostatic, and injectable hydrogels with photothermal antibacterial activity to accelerate full-thickness wound regeneration

“…29–31 Therefore, it is imperative to develop PDA-based injectable hydrogels through facile preparation. 32…”

“…[29][30][31] Therefore, it is imperative to develop PDA-based injectable hydrogels through facile preparation. 32 The metal-ligand coordination interaction with a capacity to produce hydrogels with high mechanical properties has attracted increasing attention to preparing advanced hydrogels for wound healing management. 33 Many metal ions have shown crucial roles in tissue regeneration.…”