Novel Synthesis of Omeprazole and Pharmaceutical Impurities of Proton pump inhibitors : A Review

Abstract

The objective of this review was to study the novel methods to the omeprazole synthesis and pharmaceutical impurities of proton pump inhibitors that provide an insight to researchers about the development of proton pump inhibitors. However, this paper emphasized on the study of various pharmaceutical impurities of anti-ulcer drug. The drug used for the study was omeprazole which is chemically known as (5-methoxy-2-[[(4-metboxy-3,5dimethylpyridinyl) methyl] sulfinyl]-l-benzimidazole) that inhibits gastric ATPase enzyme by oxidizingits sulfhydryl groups.The process involved during synthesis. The novel process come into existence due to incomplete oxidation of pyrmetazole and overoxidation to sulfone that leads to the formation of sulfone N-oxide. The procedure involved 5-methoxy thiobenzimidazole to the formation of an ester followed by coupling of the ester with the Grignard reagent of 2-chloromethyl-4-methoxy-3,5-dimethyl-pyridine. The novel synthesis process for pharmaceutical impurities achieve the expected yield and process observed to be short, simple. The synthesized impurity of proton pump inhibitors can be used as standard impurity, that can be utilized for further studied in various aspects. This review article will describe about the various novel impurities of omeprazole that available as marketed formulation.

Novel Thioethers of Dihydroartemisinin Exhibiting Their Biological Activities

“…In pharmaceutical chemistry research, thiols are considered as substances with a broad spectrum of activities, including anti-infammatory and anticancer activities [26][27][28][29]. Tey are widely used in drug design, and several thiols are important components of drugs such as omeprazole and lansomeprazole [30,31]. In our previous report [32], the conjugates of thiol with zerumbone, another naturally occurring sesquiterpene, exhibited activity against HepG2, A549, and HeLa cell lines with the IC 50 ranging from 0.93 to 22.40 μM, that were approximately 4-fold to 20fold stronger cytotoxic activity than that of zerumbone.…”

The efficient CO2 fixation catalyzed by K‐doped g‐C3N4 catalyst for synthesizing benzimidazoles at atmospheric pressure

“…Benzimidazole and its derivatives have been widely applied in drug synthesis and biological activity 12 . Benzimidazole is used as an intermediate for many essential drug molecules, including omeprazole, 13 cyclobendazole, 14 maribavir, 15 etc. Generally, benzimidazole and its derivatives are synthesized by reacting o ‐phenylenediamine with carboxylic acids, esters and aldehydes.…”