The objective of this review was to study the novel methods to the omeprazole synthesis and pharmaceutical impurities of proton pump inhibitors that provide an insight to researchers about the development of proton pump inhibitors. However, this paper emphasized on the study of various pharmaceutical impurities of anti-ulcer drug. The drug used for the study was omeprazole which is chemically known as (5-methoxy-2-[[(4-metboxy-3,5dimethylpyridinyl) methyl] sulfinyl]-l-benzimidazole) that inhibits gastric ATPase enzyme by oxidizingits sulfhydryl groups.The process involved during synthesis. The novel process come into existence due to incomplete oxidation of pyrmetazole and overoxidation to sulfone that leads to the formation of sulfone N-oxide. The procedure involved 5-methoxy thiobenzimidazole to the formation of an ester followed by coupling of the ester with the Grignard reagent of 2-chloromethyl-4-methoxy-3,5-dimethyl-pyridine. The novel synthesis process for pharmaceutical impurities achieve the expected yield and process observed to be short, simple. The synthesized impurity of proton pump inhibitors can be used as standard impurity, that can be utilized for further studied in various aspects. This review article will describe about the various novel impurities of omeprazole that available as marketed formulation.
hypertension is the disease which mainly occurred due to the lifestyle which is very abnormal adopted by today’s human beings. Therapy to this disease led to the prevention disease such as myocardial infarction and stroke which is very common. 13The motive behind the study is to gain the interest of the reviewer to understand the novel impurities of the hypertensive drugs and the intermediate that occur during the synthesis which will to understand the purity of the of the API formation which will conclude through the impurities formation.
Lagerstroemia indica, is a natural plant which have traditional use from the ancient medicine for the treatment of many diseases. The gastroprotective effect of methanolic extract of Lagerstroemia indica and the possible mechanisms used to investigated the ulcer activity through indomethacin-induced ulcer model. Method: male Wistar rats were divided into three groups: (normal control, n=6), (standard omeprazole group, n=6) and (extract group, n=6). Each of control, omeprazole and extract were administered orally to the rats daily for 21 days before the induction of ulcer with the help of indomethacin. On the 21 days indomethacin was administered with single oral dose (20mg/kg). Four hours later after the administration of indomethacin dose treatment, the rats were sacrificed and gastric tissue was taken for histopathological investigation for the calculation of pH, ulcer inhibition, ulcer index. The observation significantly increased (p < 0.01) value that reduced the ulcer by the treatment with Lagerstroemia indica. Result: The result indicates the antiulcer effect of the Lagerstroemia indica extracts showed significant effect during comparision with control and standard group. The data of study revealed that the extracts of Lagerstroemia indica proved to show control over the model of indomethacin-induced gastric ulceration which gives potent activity against ulceration.
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