Novel sugar‐based gemini surfactants: aggregation properties in aqueous solution

Abstract

Novel sugar-based gemini surfactants: aggregation properties on aqueous solution Johnsson, M.; Engberts, J.B.F.N.

Structural and transfection properties of amine‐substituted gemini surfactant‐based nanoparticles

“…The 12-7NH-12 surfactant clearly shows a significant change in aggregate size on going from basic to acidic pH, as a result of protonation of the imino group. While the observed change in aggregate size (from ∼2.5 to 3.7 nm radius) is not as significant as the vesicle to micelle transition observed in the sugar-based gemini surfactants [15][16][17][18][19], a clear structural change occurs on transition from neutral to acidic pH, which may aid in the release of DNA once the complex has been incorporated within the cell. The pH dependence of both particle size and zeta potential was also determined for the PGL complexes containing either the 12-7N-12 or 12-7NH-12 gemini surfactant ( Figures 4B and 4C, respectively).…”

Hydration of Ions in Confined Spaces and Ion Recognition Selectivity

“…[46][47][48][49] The zeta potential of a micelle is one of the most useful physicochemical properties of a micelle. Although there is a debate on whether the shear plane corresponds to the real surface or not, the rigorous definition of the micellar surface is of no physical significance because micelles are dynamic systems that are subject to continuous thermal perturbation.…”

Transfection mediated by pH-sensitive sugar-based gemini surfactants; potential for in vivo gene therapy applications

“…Such gemini surfactants [30] do not require helper lipids, as is the case for numerous cationic lipid-based systems, and, most importantly, liposomes prepared from such surfactants show a pH-dependent transition from the lamellar to a micellar phase [30][31][32]. In fact, helper lipids, like DOPE, frustrate this transition, thus causing a relative stabilization of the bilayer structure and emphasizing the membrane destabilizing micellar phase as a prerequisite for cytoplasmic DNA release [33].…”