Transfection mediated by pH-sensitive sugar-based gemini surfactants; potential for in vivo gene therapy applications

Development of Dioctadecyldimethylammonium Bromide/Monoolein Liposomes for Gene Delivery

“…Examples of pH-sensitive molecules used in non-viral gene delivery include polyhistidine, Development of Dioctadecyldimethylammonium Bromide/Monoolein Liposomes for Gene Delivery 253 dioleoyldimethylammonium propane (DODAP) or cholesteryl hemisuccinate (CHEMS) [112,113].…”

Encapsulation Processes by Bilayer Vesicles

“…158 As a consequence, these particles exhibit an unusually high colloidal stability (as shown by turbidity measurements) facilitating their application in in vivo gene delivery experiments. 160 In the H II c phase the polar headgroups of the amphiphile participate in electrostatic interactions with the DNA and the hydrophobic tails are exposed on the outside where they can easily induce aggregation behaviour and capture in the lung endothelium capillaries. This problem has been tackled by coating the lipoplexes with PEG -lipids that enhance the blood circulation times.…”

Study of pH-responsive surface active ionic liquids: the formation of spherical and wormlike micelles

“…Zhou et al [14] described two kinds of small amphiphilic molecules formed a pH-sensitive supramolecular hydrogel. Wasungu's group [15] surveyed pH-responsive behaviors of a series of carbohydratebased gemini surfactants, and the results showed that vesicles were formed by most of the gemini surfactants when close to the neutral pH and the vesicles transformed to WLMs when lowering pH of the solutions. These studies are all using organic synthesis to associate pH-responsive moieties with amphiphiles covalently to achieve control the viscoelastic of fluids through pH.…”