Novel silver and nanoparticle-encapsulated growth factor co-loaded chitosan composite hydrogel with sustained antimicrobility and promoted biological properties for diabetic wound healing

Lee, Yu Hsiang; Hong, Yi; Wu, Tai Li

doi:10.1016/j.msec.2020.111385

Cited by 61 publications

(35 citation statements)

References 51 publications

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“…Nano- and microscale particles fabricated by synthetic polymers such as poly(lactide-co-glycolic acid) (PLGA) were also used for incorporating EGCG to promote wound healing, with the advantages of biocompatibility and a sustainable anti-inflammatory effect [ 37 ]. In addition, some growth factors are good candidates for coating in order to endow the recombinant nanoparticles with targeted therapeutic effect in the wound area, for instance, epidermal growth factor (EGF) [ 38 , 39 ].…”

Section: The Application Forms Of Egcg To Wound Healingmentioning

confidence: 99%

Beneficial Effects of Green Tea EGCG on Skin Wound Healing: A Comprehensive Review

Zhong

et al. 2021

Molecules

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Epigallocatechin gallate (EGCG) is associated with various health benefits. In this review, we searched current work about the effects of EGCG and its wound dressings on skin for wound healing. Hydrogels, nanoparticles, micro/nanofiber networks and microneedles are the major types of EGCG-containing wound dressings. The beneficial effects of EGCG and its wound dressings at different stages of skin wound healing (hemostasis, inflammation, proliferation and tissue remodeling) were summarized based on the underlying mechanisms of antioxidant, anti-inflammatory, antimicrobial, angiogenesis and antifibrotic properties. This review expatiates on the rationale of using EGCG to promote skin wound healing and prevent scar formation, which provides a future clinical application direction of EGCG.

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Section: The Application Forms Of Egcg To Wound Healingmentioning

confidence: 99%

Beneficial Effects of Green Tea EGCG on Skin Wound Healing: A Comprehensive Review

Zhong

et al. 2021

Molecules

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“…Nanotechnologies have been used in dressings for growth factor incorporation, ameliorating growth factors bioavailability and stability. According experimental studies, EGF and FGF- incorporated dressings accelerate angiogenesis, extracellular matrix remodeling and re-epithelialization, with great potential in skin wound treatment [ 87 , 88 , 89 , 90 , 91 , 92 ].…”

Section: Wound Treatmentsmentioning

confidence: 99%

Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies

Gushiken

Beserra

Bastos

et al. 2021

Life

135

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The skin is the biggest organ of human body which acts as a protective barrier against deleterious agents. When this barrier is damaged, the organism promotes the healing process with several molecular and cellular mechanisms, in order to restore the physiological structure of the skin. The physiological control of wound healing depends on the correct balance among its different mechanisms. Any disruption in the balance of these mechanisms can lead to problems and delay in wound healing. The impairment of wound healing is linked to underlying factors as well as aging, nutrition, hypoxia, stress, infections, drugs, genetics, and chronic diseases. Over the years, numerous studies have been conducted to discover the correct approach and best therapies for wound healing, including surgical procedures and non-surgical treatments such as topical formulations, dressings, or skin substitutes. Thus, this general approach is necessary to facilitate the direction of further studies. This work provides updated concepts of physiological mechanisms, the factors that can interfere, and updated treatments used in skin wound healing.

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“…Nanotechnology devices that deliver wound healing drugs are based on nanoparticles/hydrogels in addition to bioactive pharmacological products (11). For instance, a recent in vivo study which incorporated silver ions to a chitosan hydrogel to deliver epidermal growth factor with antibacterial and cell growth effects in diabetic mice, translated into encouraging clinical effects such as re-epithelization of the area of the ulcer and increased collagen deposits in the same foot region (23).…”

Section: Dm: Past and Futurementioning

confidence: 99%

Diabetes mellitus: Plasticizers and nanomaterials acting as endocrine‑disrupting chemicals (Review)

et al. 2022

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Various plasticizers and nanomaterials have been linked to endocrine disruptors or endocrine-disrupting chemicals (EDCs) which represent a large, heterogeneous, yet incompletely understood group of structures acting on normal and pathological body pathways such as hormonal production, secretion, transport and receptor binding. By contrast, various applications of nanoparticles are currently under investigation since the delivery of useful drugs, particularly insulin in diabetes mellitus, is essential in case of insulin deficiency. The aim of the present review was to introduce and examine different plasticizers and nanomaterials with potential applications for diabetic patients (such as selenium or gold-based nanoparticles that help the oral delivery of insulin) or plasticizers/nanomaterials acting similarly to EDCs in relation to the human and animal body, particularly glucose metabolism impairment such as diabetes mellitus (DM). Bisphenol A is a chemical used worldwide; however, the effect of exposure varies with regard to the source, environment, time of exposure and the age of the organism. Daily exposure is mostly related to food and drinks stored in polycarbonate plastics. However, exposure may also be through the skin or through the maternal placenta or breast milk which are risk factors for the fetus and for the newborn. It exerts an estrogen-like profile, but it also induces insulin resistance by impairing peripheral insulin receptors or it decreases insulin secretion by acting at the level of insulin-secreting pancreatic β-cells. Phthalates, compounds of flexible plastics, act as EDCs via their human metabolites such as diethyl phthalate and derivative monoethyl phthalate. Their role in inducing gestational DM and weight gain/obesity during pregnancy has been showcased. The vast field of plasticizers and nanomolecules acting as endocrine disruptors is widely linked to clinical aspects of DM, a serious condition with a major population impact. The importance of understanding and using these agents and applications is reflected in saving numerous human lives. Contents 1. Introduction 2. Diabetes mellitus (DM): Past and future 3. Conclusions

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Novel silver and nanoparticle-encapsulated growth factor co-loaded chitosan composite hydrogel with sustained antimicrobility and promoted biological properties for diabetic wound healing

Cited by 61 publications

References 51 publications

Beneficial Effects of Green Tea EGCG on Skin Wound Healing: A Comprehensive Review

Beneficial Effects of Green Tea EGCG on Skin Wound Healing: A Comprehensive Review

Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies

Diabetes mellitus: Plasticizers and nanomaterials acting as endocrine‑disrupting chemicals (Review)

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