Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies

Gushiken, Lucas Fernando Sérgio; Beserra, Fernando Pereira; Bastos, Jairo Kenupp; Jackson, Christopher J.; Pellizzon, Cláudia Helena

doi:10.3390/life11070665

Cited by 125 publications

(106 citation statements)

References 101 publications

(210 reference statements)

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“…Cell proliferation requires an adequate blood supply in order to receive sufficient oxygen and nutrients [ 8 ]; therefore, the following stage is marked by epithelialization, angiogenesis, granulation tissue formation and collagen deposition [ 1 ]. This process involves several cell types, including fibroblasts, macrophages and endothelial cells, which exert interdependent activity during wound management.…”

Section: Introductionmentioning

confidence: 99%

“…During the inflammatory stage, indeed, immune cells, namely mastocytes, which release cytokines as well as lysosomal enzymes and reactive oxygen species (ROS), migrate to the injury site, thus causing the appearance of oedema and erythema [4]. This process involves also different players, such as Langerhans cells, one of the primary cell types of the immunological barrier, which play an important role during the inflammatory phase of acute wound healing [5], and gamma-delta cells involved in inflammation and reepithelialization and required for efficient skin wound healing [6,7] Cell proliferation requires an adequate blood supply in order to receive sufficient oxygen and nutrients [8]; therefore, the following stage is marked by epithelialization, angiogenesis, granulation tissue formation and collagen deposition [1]. This process involves several cell types, including fibroblasts, macrophages and endothelial cells, which exert interdependent activity during wound management.…”

Section: Introductionmentioning

confidence: 99%

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Angiogenin and Copper Crossing in Wound Healing

Cucci

Satriano

Marzo

et al. 2021

IJMS

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Angiogenesis plays a key role in the wound healing process, involving the migration, growth, and differentiation of endothelial cells. Angiogenesis is controlled by a strict balance of different factors, and among these, the angiogenin protein plays a relevant role. Angiogenin is a secreted protein member of the ribonuclease superfamily that is taken up by cells and translocated to the nucleus when the process of blood vessel formation has to be promoted. However, the chemical signaling that activates the protein, normally present in the plasma, and the transport pathways through which the protein enters the cell are still largely unclear. Copper is also an angiogenic factor that regulates angiogenin expression and participates in the activation of common signaling pathways. The interaction between angiogenin and copper could be a relevant mechanism in regulating the formation of new blood vessel pathways and paving the way to the development of new drugs for chronic non-healing wounds.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Angiogenin and Copper Crossing in Wound Healing

Cucci

Satriano

Marzo

et al. 2021

IJMS

View full text Add to dashboard Cite

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“…Therefore, impaired immune function is clinically correlated with sarcopenia [44]. Malnutrition is a major cause of delayed wound healing [45]. According to consensus updates about the Global Leadership Initiative on Malnutrition [46], diagnostic criteria must include an evaluation of involuntary weight loss, low BMI, and low muscle mass, in addition to etiological factors.…”

Section: Discussionmentioning

confidence: 99%

Association between Sarcopenia and Immediate Complications and Mortality in Patients with Oral Cavity Squamous Cell Carcinoma Undergoing Surgery

Huang

Lue

Chen

et al. 2022

Cancers

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Sarcopenia negatively affects oncologic outcomes. However, studies have yet to reveal whether it is associated with postoperative complications and survival among patients with oral cavity squamous cell carcinoma (OSCC). This study retrospectively enrolled 592 patients undergoing primary OSCC surgery with available computed tomography (CT) images of their third cervical vertebrae (C3) within 30 days before surgery between January 2011 and December 2020. Preoperative sarcopenia, nutritional and frailty status, tumor characteristics, comorbidities, and inflammatory markers were assessed. The outcome variables included 30-day complications based on the Buzby and Dindo classification, reoperation, 5- and 8-year overall survival, and disease-free survival. A total of 318 (53.7%) had sarcopenia; of these patients, 217 (68.2%) presented with postoperative complications, and 48 (15.1%) underwent reoperations. Sarcopenia and higher systemic immune-inflammatory index were independently associated with local to systemic 30-day complications. Sarcopenia, advanced-stage disease, and extracapsular spread were correlated with 5- and 8-year survival. The presence of sarcopenia is associated with the 30-day complications and short- and long-term survival of patients who had OSCC and underwent surgery.

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“…Pre-existing IL-1β may also play a role in driving paradoxical responses that are observed at the outset of antibiotic treatment. As well as directing pathogenesis and antimicrobial immune responses, IL-1 also plays an important role in wound healing ( 89 , 90 ), which likely becomes important during spontaneous healing. Moreover, other IL-1 family cytokines utilize the same strategies for protein expression and unconventional protein secretion, including IL-18, IL-33, IL-36, IL-37, and IL-38 ( 88 , 91 ).…”

Section: Discussion - Potential Implications Of Il-1β Induction For B...mentioning

confidence: 99%

The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer

et al. 2022

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Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a devastating necrotizing skin disease. Key to its pathogenesis is mycolactone, the exotoxin virulence factor that is both immunosuppressive and cytotoxic. The discovery that the essential Sec61 translocon is the major cellular target of mycolactone explains much of the disease pathology, including the immune blockade. Sec61 inhibition leads to a loss in production of nearly all cytokines from monocytes, macrophages, dendritic cells and T cells, as well as antigen presentation pathway proteins and costimulatory molecules. However, there has long been evidence that the immune system is not completely incapable of responding to M. ulcerans infection. In particular, IL-1β was recently shown to be present in BU lesions, and to be induced from M. ulcerans-exposed macrophages in a mycolactone-dependent manner. This has important implications for our understanding of BU, showing that mycolactone can act as the “second signal” for IL-1β production without inhibiting the pathways of unconventional secretion it uses for cellular release. In this Perspective article, we validate and discuss this recent advance, which is entirely in-line with our understanding of mycolactone’s inhibition of the Sec61 translocon. However, we also show that the IL-1 receptor, which uses the conventional secretory pathway, is sensitive to mycolactone blockade at Sec61. Hence, a more complete understanding of the mechanisms regulating IL-1β function in skin tissue, including the transient intra-macrophage stage of M. ulcerans infection, is urgently needed to uncover the double-edged sword of IL-1β in BU pathogenesis, treatment and wound healing.

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Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies

Cited by 125 publications

References 101 publications

Angiogenin and Copper Crossing in Wound Healing

Angiogenin and Copper Crossing in Wound Healing

Association between Sarcopenia and Immediate Complications and Mortality in Patients with Oral Cavity Squamous Cell Carcinoma Undergoing Surgery

The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer

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