Novel serum inflammatory markers in patients with adnexal mass who had surgery for ovarian torsion

Daponte, Alexandros; Pournaras, Spyros; Hadjichristodoulou, Christos; Lialios, Georgios; Kallitsaris, A.; Maniatis, Antonios N.; Messinis, Ioannis E.

doi:10.1016/j.fertnstert.2005.10.056

Cited by 49 publications

(41 citation statements)

References 12 publications

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“…Using a cut-off point of 10.2 pg/ml, sensitivity was 92.3%, specificity 78.1%, positive predictive value 63.2%, and negative predictive value 96.2%. In this study, the authors failed to identify any other inflammatory markers associated with torsion [3]. Case reports have also reported CA-125 as a diagnostic marker of ovarian torsion [19].…”

Section: Discussionmentioning

confidence: 80%

Is the Measurement of Serum Ischemia-Modified Albumin the Best Test to Diagnose Ovarian Torsion?

Güven

Kart²,

Güven³

et al. 2015

Gynecol Obstet Invest

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Aim: The aim of this study is to evaluate the diagnostic value of serum oxidative stress marker levels (ischemia-modified albumin, IMA; malondialdehyde, MDA) and total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) levels that occur in ovarian torsion and to determine the threshold value of these markers in the diagnosis of ovarian torsion. Methods: In this prospective case-control study, 34 women (the study group) with acute pelvic pain (20 with and 14 without ovarian torsion) and 40 control subjects were included. The diagnosis of ovarian torsion was confirmed with laparoscopy in all cases. Preoperative serum samples were collected in the study group. Serum oxidative stress marker levels (IMA and MDA) and TOS, TAS and OSI levels were measured. Results: Serum MDA, TOS and IMA concentrations were significantly higher in women with ovarian torsion than in the healthy control group. However, serum TAS, TOS and OSI concentrations were significantly higher in women without ovarian torsion than within the healthy control group. Only IMA significantly distinguished patients with or without ovarian torsion. The best IMA value, according to the receiver operating characteristic curve, was 0.7045 absorbance units, with 90.00% sensitivity and 92.31% specificity. The patients in the ovarian torsion group had significantly lower serum TAS and OSI levels compared with patients without ovarian torsion. Conclusion: The elevated serum IMA levels with high sensitivity-specificity values observed in women with ovarian torsion seem to have a potential role as a serum marker in the preoperative diagnosis of ovarian torsion in emergency settings.

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Section: Discussionmentioning

confidence: 80%

Is the Measurement of Serum Ischemia-Modified Albumin the Best Test to Diagnose Ovarian Torsion?

Güven

Kart²,

Güven³

et al. 2015

Gynecol Obstet Invest

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“…A total of three studies met their inclusion criteria [2,12,13]. The pooled results indicate a sensitivity of 85.7 % and a positive likelihood ratio of 5.6 for the use of serum interleukin-6 for the diagnosis of ovarian torsion.…”

Section: Discussionmentioning

confidence: 98%

“…Serum D-dimer, ischemia-modified albumin, IL-6, IL-8, TNF-a, and E-selectin, have been investigated as serum markers in patients with ovarian torsion. Among these, elevated IL-6, D-dimer, and ischemia-modified albumin concentrations have been shown to be associated with ovarian torsion [2,[11][12][13][14][15]. Kart et al investigated the diagnostic value of plasma D-dimer level in an experimental rat ovarian torsion model and stated that D-dimer was well correlated with histopathological damage scores of ovarian injury and might be used as a plasma marker in early detection of ovarian torsion [14].…”

Section: Discussionmentioning

confidence: 99%

High-sensitivity C-reactive protein as a novel marker in early diagnosis of ovarian torsion: an experimental study

Bakacak

Köstü

Ercan

et al. 2014

Arch Gynecol Obstet

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“…Among situations investigated and treated surgically, IL-6 was also associated with intestinal ischemia [25]. According to their data, Daponte et al [26] claim that estimation of serum IL-6 level in a female patient with adnexal mass and acute abdominal pain, with possible ovarian torsion, can help in differentiating patients, who will benefit from emergency surgical intervention, from others who could be treated conservatively. In the present study, serum IL-6 levels of ischemia group were significantly higher than the control group and both L-carnitine and NAC groups.…”

Section: Discussionmentioning

confidence: 99%

Tissue damage in rat ovaries subjected to torsion and detorsion: effects of l-carnitine and N-acetyl cysteine

et al. 2008

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We aimed to evaluate histopathological changes, to detect HIF-1alpha staining intensities and to determine MDA levels in rat ovaries, which were subjected to torsion and detorsion and treated with L -carnitine or N-acetyl cysteine (NAC). Forty-eight prepubertal female Sprague-Dawley rats were divided into five groups (n = 8): 1, control; 2, ischemia; 3, reperfusion; 4, L -carnitine; and 5, NAC groups. In groups 3, 4 and 5, an ischemic period of 3 h was followed by reperfusion for 24 h. In groups 4 and 5, ischemia was performed and either L -carnitine or NAC was infused intraperitoneally 30 min before reperfusion. Ovarian tissues were examined histopathologically; tissue MDA levels and serum IL-6 levels were determined biochemically. HIF-1alpha was applied to all ovaries immunohistochemically. Total tissue damage scores, tissue MDA levels and HIF-1alpha scores, were significantly higher in group 2 (all P < 0.001) than group 4, and group 3 than group 4 (P < 0.001, P = 0.05 and P < 0.001, respectively). They were also significantly higher in group 2 (all P < 0.001) than group 5. When group 3 is compared to group 5, total tissue damage scores and tissue MDA levels were significantly higher in the former (P < 0.01 and P < 0.001, respectively). Serum IL-6 levels were significantly higher in group 2 when compared to groups 1, 4 and 5 (all P < 0.01). The degree of tissue damage of the torsioned ovaries decreased after a reperfusion period of 24 h in the torsioned ovaries. However, ovaries of both L -carnitine and NAC groups showed better recovery than the reperfusion group.

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Novel serum inflammatory markers in patients with adnexal mass who had surgery for ovarian torsion

Cited by 49 publications

References 12 publications

Is the Measurement of Serum Ischemia-Modified Albumin the Best Test to Diagnose Ovarian Torsion?

Is the Measurement of Serum Ischemia-Modified Albumin the Best Test to Diagnose Ovarian Torsion?

High-sensitivity C-reactive protein as a novel marker in early diagnosis of ovarian torsion: an experimental study

Tissue damage in rat ovaries subjected to torsion and detorsion: effects of l-carnitine and N-acetyl cysteine

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