Novel secondary metabolites from endophytic fungi: synthesis and biological properties

Rustamova, Nigora; Bozorov, Khurshed; Efferth, Thomas; Yili, Abulimiti

doi:10.1007/s11101-020-09672-x

Cited by 62 publications

(38 citation statements)

References 89 publications

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“…However, taxol production has been discovered also in a wide variety of fungal species like the endophytic fungi Pestalotiopsis microspora and Stemphylium sedicola which have been isolated from plant species of the genus Taxus and Taxodium . Likewise, the compounds azadirachtin A and B, which are widely used as natural insecticides and traditionally isolated from neem tree, Azadirachta indica , are also produced by the endophytic fungus Eupenicillium parvum isolated from neem tree [ [23] , [24] , [25] , [26] , [27] ].…”

Section: Resultsmentioning

confidence: 99%

Effect of methyl jasmonate and salicylic acid on the production of metabolites in cell suspensions cultures of Piper cumanense (Piperaceae)

Rodríguez-Sánchez

Pérez-Bernal

Santamaría-Torres

et al. 2020

Biotechnology Reports

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Highlights MeJA and SA induced a differential metabolic production in elicited cell suspensions. Production of metabolites was dependent on the type and the concentration of elicitor. Elicitation with SA produced the greatest changes in the metabolic profile. 5-hidroximetilfurfural, (Z)-9-octadecenamide and phenol were induced by elicitation.

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Section: Resultsmentioning

confidence: 99%

Effect of methyl jasmonate and salicylic acid on the production of metabolites in cell suspensions cultures of Piper cumanense (Piperaceae)

Rodríguez-Sánchez

Pérez-Bernal

Santamaría-Torres

et al. 2020

Biotechnology Reports

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“… 33 Polyketides are a class of fungal secondary metabolites, and many of them demonstrate fascinating biological activities. 34 Therefore, the isolated compounds were tested for several bioactivities such as cytotoxicity and anti-inflammation. Due to limited sample amounts, compounds 1 – 4 and 6 were not able to be evaluated in their anti-inflammation assay.…”

Section: Resultsmentioning

confidence: 99%

Secondary Metabolites and Bioactivities of Aspergillus ochraceopetaliformis Isolated from Anthurium brownii

Tsai

et al. 2020

ACS Omega

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Five new polyketides, asperochrapyran ( 1 ) and asperochralactones A–D ( 2 – 5 ), along with 12 known polyketides ( 6 – 17 ), were obtained from the fungal strain Aspergillus ochraceopetaliformis . Structures of all isolates were elucidated by their spectroscopic parameters. The relative configurations of the new compounds were deduced by the data of coupling constants and NOESY spectra. The absolute configurations were determined by the comparison of experimental and calculated ECD spectra. Moreover, the plausible biosynthesis pathway of major isolates was proposed as well. Anti-inflammatory activity of compounds 5 and 7 – 17 were evaluated with human neutrophils in response to the stimulation of formyl-methionyl-leucyl phenylalanine (fMLP). Asperlactone ( 9 ), aspyrone ( 13 ), and (−)-(3 R )-mellein ( 14 ) exerted superoxide anion inhibition at 30 ± 9%, 29 ± 9%, and 26 ± 12%, respectively, at 10 μM. The capacities of asperlactone ( 9 ), aspilactonol B ( 10 ), penicillic acid ( 12 ), and (−)-(3 R )-mellein ( 14 ) in elastase release inhibition were revealed as 25 ± 4%, 38 ± 8%, 25 ± 5%, and 34 ± 9%, respectively, at 10 μM.

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“…Some bioactive compounds such as triterpenoids, sesquiterpenes, and diterpenoids produced from endophytic fungi account for their antimicrobial activity against some fungal and bacterial pathogens [ 45 ]. In Chinese herbal medicines, diverse fungal endophyte communities isolated from the roots of Paris polyphylla have traditionally been employed.…”

Section: Pharmacological Effects Of Bioactive Compounds Of Fungal mentioning

confidence: 99%

Pharmacological Potential of Fungal Endophytes Associated with Medicinal Plants: A Review

Adeleke

Babalola

2021

JoF

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Endophytic microbes are microorganisms that colonize the intracellular spaces within the plant tissues without exerting any adverse or pathological effects. Currently, the world population is facing devastating chronic diseases that affect humans. The resistance of pathogens to commercial antibiotics is increasing, thus limiting the therapeutic potential and effectiveness of antibiotics. Consequently, the need to search for novel, affordable and nontoxic natural bioactive compounds from endophytic fungi in developing new drugs with multifunction mechanisms to meet human needs is essential. Fungal endophytes produce invaluable bioactive metabolic compounds beneficial to humans with antimicrobial, anticancer, antidiabetic, anti-inflammatory, antitumor properties, etc. Some of these bioactive compounds include pestacin, taxol, camptothecin, ergoflavin, podophyllotoxin, benzopyran, isopestacin, phloroglucinol, tetrahydroxy-1-methylxanthone, salidroside, borneol, dibenzofurane, methyl peniphenone, lipopeptide, peniphenone etc. Despite the aforementioned importance of endophytic fungal metabolites, less information is available on their exploration and pharmacological importance. Therefore, in this review, we shall elucidate the fungal bioactive metabolites from medicinal plants and their pharmacological potential.

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Novel secondary metabolites from endophytic fungi: synthesis and biological properties

Cited by 62 publications

References 89 publications

Effect of methyl jasmonate and salicylic acid on the production of metabolites in cell suspensions cultures of Piper cumanense (Piperaceae)

Effect of methyl jasmonate and salicylic acid on the production of metabolites in cell suspensions cultures of Piper cumanense (Piperaceae)

Secondary Metabolites and Bioactivities of Aspergillus ochraceopetaliformis Isolated from Anthurium brownii

Pharmacological Potential of Fungal Endophytes Associated with Medicinal Plants: A Review

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