Novel role of nanotechnology in medicine

Singla, Heena; Singla, Neeraj

doi:10.7439/ijbr.v5i8.730

Cited by 5 publications

(4 citation statements)

References 33 publications

(27 reference statements)

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“…On the other side when transcription takes place, the mRNA is released as biosignal followed by translation of target protein (Kesharwani et al 2014b, c). Conjugation of PEG to PAMAM dendrimers is described by Huang et al (2007) and Singla and Singla (2014). Synthetic nonviral vectors, like poly-L-lysine which shows a polycationic behaviour, decrease the cytotoxicity (Oliveira et al 2010;Gómez-Valadés et al 2005).…”

Section: Dendrimers In Gene Deliverymentioning

confidence: 99%

A review on comparative study of PPI and PAMAM dendrimers

et al. 2016

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Dendrimers are hyperbranched, monodispersed macromolecules with multivalent functional end groups. Dendrimers have been explored as carrier for many drugs like anticancer, antiviral, antimalarial, antiprotozoal, anti tubercular drugs. Although a number of different types of dendrimers containing different core molecules, branching monomers and surface functional groups have been designed till date for drug delivery applications, yet the poly(propyleneimine) (PPI) and poly(amidoamine) (PAMAM) dendrimers have been the most explored dendrimers in this regard. In this review, we have summarized a comparative data on PPI and PAMAM dendrimers particularly relevant to their properties, synthesis, toxicity, biomedical applications and drug delivery attributes.

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Section: Dendrimers In Gene Deliverymentioning

confidence: 99%

A review on comparative study of PPI and PAMAM dendrimers

et al. 2016

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“…For example, for nanoimaging paramagnetic iron oxide, nanoparticles are used as contrast agent, in the event of molecular analysis in vivo. Nanotechnological applications are also used for in vitro diagnosis, by using contrast agents as fluorescent dyes and magnetic nanoparticles (Saini et al 2010;Singla and Singla 2014). As regards the regenerative nanomedicine, the challenge is to enhance tissue regeneration while minimizing immune responses avoiding infection.…”

Section: Resultsmentioning

confidence: 99%

Nanotechnology for social needs: contributions from Latin American research in the areas of health, energy and water

et al. 2015

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This paper reviews, based on data from scientific publications and research groups, the state of the art of nanotechnology research applied to the areas of medicine, energy and water in Latin America. Such areas have been considered as particularly relevant in order to meet the social needs of the developing countries. It is shown that the countries in the region have incorporated these areas to their nanotechnology agendas and several countries have increasing research capacities. However, such capacities are concentrated in Brazil and Mexico, while the regional cooperation networks are still weak. Although the research topics tend to align with relevant social issues, there are still a number of challenges so as the results of such investigations may be effectively reflected in quality of life improvements; one of them is that many publications and research topics are on basic science, which makes it difficult to evaluate their potential application field.

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“…Throughout worldwide many research groups are trying to bind anticancer drug to surface of nanotubes. [1][2][3] Eventhough nanoparticles, dendrimers and liposomes have been tried to load and target anticancer drugs, carbon nanotubes (CNT) have been increasingly utilized in the field of cancer therapy. CNTs are made of looks tube like with a diameter of nanoscale.…”

Section: Introductionmentioning

confidence: 99%

HCT116 Cells Cytotoxic Response to Multifuctionalized 5- Fluorouracil MWCNTs Conjugates In Colorectal Cancer

K.P.¹

2021

ijcsrr

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Nanomaterials are the foundations of Nanotechnology, which are measured in nanoscales, Carbon nanotubes are one of the interesting nanomaterials, studied for over 25 years because of their superlative properties such as high surface area, electrical and thermal conductivity, high biocompatibility, flexibility, resistance to corrosion and nanosize. According to research, carbon nanotubes are applied in sensing, water treatment, and drug delivery, mainly used to deliver the anticancer drugs. In our work, functionalization of multi walled carbon nanotubes done by covalent and non-covalent functionation methods, covalent functionalization showed better dispersing efficiency in aqueous medium and compatible with biological systems with damaging the crystal lattice of carbon nanotubes. Non covalent functionalization helps to derivatized with active compounds, surface adsorption or attachment of various molecules or antibodies, which subsequently helps in targeting the site and to produce therapeutic effects. Different formulations prepared by functionalized MWCNTs and multiple functionalization of MWCNTs done by binding the drug and antibodies to prepare functionalized MWCNTs 5-Fluorouracil complexes. The Cytotoxicity assay was carried out for the obtained new targeting formulations to analyze the effect of all the formulations on HCT116 cell line. The percentage death was determined based on the viability of the cells in the appropriate vehicle controls. In this study, we report the successful functionalization, binding of 5 Fluorouracil, antibodies to MWCNTs, and cells viability of all prepared formulations for the development of novel carbon based anticancer drug delivery system. Functionalized MWCNTs-5-Fluorouracil antibodies composite at concentration above 2.5 µg/mL exhibited ≥ 50% cytotoxicity post normalization with compound control to negate precipitation observed with the compound. All the formulations showed the precipitations indicating antitumor activity and biocompatibility.

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Novel role of nanotechnology in medicine

Cited by 5 publications

References 33 publications

A review on comparative study of PPI and PAMAM dendrimers

A review on comparative study of PPI and PAMAM dendrimers

Nanotechnology for social needs: contributions from Latin American research in the areas of health, energy and water

HCT116 Cells Cytotoxic Response to Multifuctionalized 5- Fluorouracil MWCNTs Conjugates In Colorectal Cancer

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