A review on comparative study of PPI and PAMAM dendrimers

Kaur, Daljeet; Jain, Keerti; Mehra, Neelesh Kumar; Kesharwani, Prashant; Jain, Narendra Kumar

doi:10.1007/s11051-016-3423-0

Cited by 122 publications

(64 citation statements)

References 67 publications

(67 reference statements)

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“…Different types of dendrimers have so far been reported. The most commonly used are polyamidoamine (PAMAM) and polypropyleneimine (PPI) dendrimers (Kaur et al 2016) with cores of EDA, DAB or TC, and terminal groups like aldheyde, amine, carboxylate, succinamic acid or amidoethanol (Fig. 2).…”

Section: Dendrimersmentioning

confidence: 99%

Relation between biophysical properties of nanostructures and their toxicity on zebrafish

et al. 2017

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In recent years, the use of commercial nanoparticles in different industry and health fields has increased exponentially. However, the uncontrolled application of nanoparticles might present a potential risk to the environment and health. Toxicity of these nanoparticles is usually evaluated by a fast screening assay in zebrafish (Danio rerio). The use of this vertebrate animal model has grown due to its small size, great adaptability, high fertilization rate and fast external development of transparent embryos. In this review, we describe the toxicity of different micro-and nanoparticles (carbon nanotubes, dendrimers, emulsions, liposomes, metal nanoparticles, and solid lipid nanoparticles) associated to their biophysical properties using this model. The main biophysical properties studied are size, charge and surface potential due to their impact on the environment and health effects. The review also discusses the correlation of the effects of the different nanoparticles on zebrafish. Special focus is made on morphological abnormalities, altered development and abnormal behavior. The last part of the review debates changes that should be made in future directions in order to improve the use of the zebrafish model to assess nanotoxicity.

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Section: Dendrimersmentioning

confidence: 99%

Relation between biophysical properties of nanostructures and their toxicity on zebrafish

et al. 2017

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“…PAMAM dendrimers were prepared according to a method reported previously [25,26], and the route was shown in Fig. 2.…”

Section: Synthesis Of Pamam Dendrimersmentioning

confidence: 99%

Emulsion-templated, polymerization-free, ultralight sponges for oil spills reclamation

Zhang¹,

Wu²,

Hu³

et al. 2019

Desalination and Water Treatment

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a b s t r a c tWe report the fabrication of monolithic, macroporous, hydrophobic polymer sponges from a water-in-oil (w/o) high internal phase emulsion (HIPE) without using polymerization process. They were formed from sulfonated polystyrene-block-poly(ethylene-ran-butylene)-block-polystyrene (SSEBS) and tetra-functional poly(amidoamine) (PAMAM) dendrimers via ionic interaction within a W/O HIPE. The sponges obtained possessed typical emulsion-templated interconnected macroporous structures, with void size ranging from 1 to 20 μm and a density of 0.08-0.1 g mL -1 . The sponges were hydrophobic, with a water contact angle of around 128.1°, enabling highly selective absorption of oil from oil-water mixture with an absorption capacity from 15.4 to 25.8 g g -1 for organic solvents and oils. The sponges were recyclable and their absorption capacity was preserved at around 85% after being reused for 30 times. The high selectivity, absorption capacity and reusability enabled these sponges to be an excellent candidate in the reclamation of oils from wastewater and oil leakage.

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“…Positive charges [103] Linear polymers [24,[104][105][106][107]113,[116][117][118][119][120][121][122][123][124] Branched polymers [24,106,113,115,116,[125][126][127] Dendrimers [108][109][110][111][112]116] Charge-reversal [103] Linear polymers [11,22,129,132,133,135] Micelles [128,130,131,134,236] Dendrimers [136] Volumetric expansion Nanoparticles [237] Membranedisrupting peptides Endosomes/ lysosomes [102] N-terminal HA2 peptide derivative Linear polymers [21] INF-7 peptide Linear polymers [137,138] GALA PEGylated liposomes …”

Section: Endosomes/ Lysosomesmentioning

confidence: 99%

“…[103][104][105][106][107] Other amine-functionalized polymers that have been widely used to promote cytosolic release of oligonucleotides and pDNA are PAMAM and poly(propyleneimine) (PPI) dendrimers. [103,[108][109][110][111][112] PEI has been proposed to act via the proton sponge effect. [102,103] According to this hypothesis, PEI, and more in general poly mers that contain a large number of secondary and tertiary amine groups with pK a values between physiological and lysosomal pH, can be protonated in the endosomal environment.…”

Section: Endosomal Disruptionmentioning

confidence: 99%

“…[113][114][115][116] PAMAM and PPI dendrimers have also been shown in vitro and in vivo to be cytotoxic and hemolytic. [108] A number of approaches have been proposed to reduce the cytotoxicity of PLL and PEI and enhance transfection efficiency. First, to shield the positive charges and to reduce toxicity, the grafting of PEG chains on PEI and PLL, [24,[117][118][119] as well as the modification of PLL with PHPMA was explored.…”

Section: Endosomal Disruptionmentioning

confidence: 99%

See 1 more Smart Citation

Controlling and Monitoring Intracellular Delivery of Anticancer Polymer Nanomedicines

Battistella

Klok

2017

Macromolecular Bioscience

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Polymer nanomedicines are very attractive to improve the delivery of chemotherapeutics. Polymer conjugates and other polymer‐based nanocarriers allow to increase plasma half‐life and drug bioavailability and can also be guided toward tumors using passive and active targeting strategies. Since many chemotherapeutics act on targets that are located in well‐defined subcellular compartments, other important factors that contribute to an efficient therapy include cellular internalization and subsequent intracellular trafficking of the polymer nanomedicines and/or its payload to the appropriate organelle in the cytoplasm. This article provides an overview of the different approaches that have been developed to control intracellular delivery of polymer nanomedicines and discusses the different techniques that can be used to monitor these processes.

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A review on comparative study of PPI and PAMAM dendrimers

Cited by 122 publications

References 67 publications

Relation between biophysical properties of nanostructures and their toxicity on zebrafish

Relation between biophysical properties of nanostructures and their toxicity on zebrafish

Emulsion-templated, polymerization-free, ultralight sponges for oil spills reclamation

Controlling and Monitoring Intracellular Delivery of Anticancer Polymer Nanomedicines

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