Novel Recombinant Foot-and-Mouth Disease Virus Circulating in Vietnam

Abstract

We report the genome sequences of 12 recombinant foot-and-mouth disease virus isolates from Vietnam. The recombinant strain has a capsid region from an A/Sea-97 strain and a nonstructural segment from an O/ME-SA/PanAsia strain. The isolates were obtained from two outbreak samples collected in June 2017 and 10 subclinical samples collected between 2017 and 2019.

Use of Slaughterhouses as Sentinel Points for Genomic Surveillance of Foot-and-Mouth Disease Virus in Southern Vietnam

“…4-2019.6), and the earliest detection of this cluster in a slaughterhouse was in January 2017 (Table 3). For three clusters in serotype O (clusters O-8, O-9, O-10) and one cluster in serotype A (cluster A-4), clusters were detected in outbreak Some (17/56, 30.1%) sequences in serotype A-cluster A-9 were previously identified as recombinant sequences within a different study analyzing full-length sequences [39]. Although the VP1 portion of these viruses is not recombinant and belongs to A/Sea-97, other parts of the genome belong to O/ME-SA/PanAsia.…”

“…Supplementary Tables S8 and S9 show details of clusters with more than ten sequences, including the lineage to which they belong, place of isolation across years, species, and within-and between-group genetic distances for both serotypes O and A. Some (17/56, 30.1%) sequences in serotype A-cluster A-9 were previously identified as recombinant sequences within a different study analyzing full-length sequences [39]. Although the VP1 portion of these viruses is not recombinant and belongs to A/Sea-97, other parts of the genome belong to O/ME-SA/PanAsia.…”

Foot-and-Mouth Disease Virus Serotypes O and A from Outbreaks in Pakistan 2011–2012

“…FMDV exists as seven serotypes with multiple lineages and subtypes that are clinically indistinguishable ( 4 ). Continuous genomic surveillance of FMDVs circulating in endemic regions is therefore critical to understand transmission pathways and inform and update preventative vaccination strategies ( 5 , 6 ).…”

Multiple Genome Sequences of Foot-and-Mouth Disease Virus Asia-1 Lineage Sindh-08 from Outbreaks in Pakistan, 2011 to 2012

“…FMDV exists as seven serotypes with multiple lineages and subtypes that are clinically indistinguishable ( 4 ). Continuous genomic surveillance of the FMDVs circulating in regions of endemicity is therefore critical to inform and update preventative vaccination strategies ( 5 , 6 ).…”