Novel pyridazine derivatives: Synthesis and antimicrobial activity evaluation

Silver Nanoparticles Effect on Antimicrobial and Antifungal Activity of New Heterocycles

“…25,26 Heterocycles bearing nitrogen, sulfur and thiazole moieties constitute the core structure of a number of biologically interesting compounds. 27 In continuation of our research for the synthesis of series of new biologically active heterocycles, [28][29][30][31] the purpose of this study was to design and synthesis new heterocycles using hydrazine pyridazine derivatives 1a-d as key materials and investigate the preliminary screening for antibacterial and antifungal activities for some of the new heterocycles using silver nanoparticles (Ag-NPs) to study the combination effect of silver nanoparticles solution on their biological activity. Refluxing of 1a-d with unsaturated aliphatic aldehyde such as crotonaldehyde in ethanol gave the corresponding hydrazones 5a-d.…”

Synthesis, characterization andin vitroantimicrobial evaluation of new compounds incorporating oxindole nucleus

“…In continuation of our interest in N-aminophthalimide chemistry, with a view directed towards preparing biologically active compounds 33,35 , in the present article, we studied the reaction of 2-(5-substituted 2-oxindolin-3-ylideneamino) isoindolin-1,3-diones (2 a,b ) with different amines. When 2-(5-substituted 2-oxindolin-3-ylideneamino) isoindolin-1,3-diones (2 a,b ) were reacted with benzylamine, they underwent ring cleavage to give N,N′-dibenzylphthalamide (5), as expected (mp, mixed melting point with authentic sample) 33,34 , in addition to 3-hydrazonoindolin-2-ones (8 a,b ) as by-product.…”

“…We investigated earlier the reaction of isatin, N-aminophthalimide or pyridazines as key starting materials for the synthesis of biologically active compounds [32][33][34][35][36][37][38][39][40] . In the present work, we studied the reaction of 5-substituted isatins and 1-hydroxy methylisatin (1 a-c ) with different amines, such as N-aminophthalimide, 1H-benzodimidazol-2-amine and sulphamethoxazole.…”

New pyrano[2,3-c]pyridazine derivatives with antimicrobial activity synthesized using piperidine as the organocatalyst

“…Due to the important biological activities of pyridazines and pyrans, we hypothesized that the synthesis of new heterocycles containing both pyridazine and pyran moieties might result in the design of new drug candidates. Therefore, in continuation of our efforts on the design and efficient synthesis of new biologically active compounds and in particular pyridazines [18][19][20][21][22][23][24][25][26][27] , herein we report a new and simple method for the synthesis of polyfunctionalized pyrano-fused pyridazine systems.…”