Silver Nanoparticles Effect on Antimicrobial and Antifungal Activity of New Heterocycles

Kandile, Nadia G.; Zaky, Howida T.; Mohamed, Mohamed Bakr; Mohamed, Hemat M.

doi:10.5012/bkcs.2010.31.12.3530

Cited by 44 publications

(22 citation statements)

References 36 publications

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“…Thus, condensation of 11 with 2-furanaldehyde in boiling ethanol, produced the hydrazone derivative 13. 38) While, 1,2,4-triazolo[3,4-a]-phthalazines 14, and 15 have been prepared upon the reaction of 11 with carbon electrophiles namely, acetic anhydride and carbon disulphide, respectively.…”

Section: Resultsmentioning

confidence: 99%

Facile Synthesis, Characterization, and Antimicrobial Evaluation of Novel Heterocycles, Schiff Bases, and <i>N</i>-Nucleosides Bearing Phthalazine Moiety

Azab

Rizk

Mahmoud

2016

CHEMICAL & PHARMACEUTICAL BULLETIN

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The present work describes convenient synthesis of the novel Schiff bases 5a and b by reacting phthalazinones 4a and b with 4-methoxybenzaldehyde Reaction of the Schiff bases with phenylisothiocyanate afforded diazetidine derivatives 7a and b. Also, compounds 4a and b reacted with 2-bromoglucoside tetraacetate giving peracetylated N-glycosides 6a and b, which were deacetylated to afford N-glycosylated phthalazinones 8a and b. On the other hand, when compound 3 was treated with POCl 3 /PCl 5 and/or ethyl chloroacetate, chlorophthalazine and ethyl acetate derivatives 9 and 10 were obtained, respectively. Hydrazinolysis of compounds 9 and 10 produced the hydrazino and hydrazide derivatives 11 and 12, respectively. When compound 11 reacted with 2-furanaldehyde, acetic anhydride, and/or carbon disulphide, it gave compounds 13-15, respectively. Treatment of the hydrazide 12 with aromatic aldehydes, acetic anhydride, ethyl acetoacetate, acetyl acetone, ammonium thiocyanate, and/or phthalic anhydride furnished compounds 17-21. Meanwhile, reacting Schiff base 22 with the chlorophthalazine derivative 9 produced compound 23, which on treatment with furoyl chloride produced compound 24. The structures of the novel compounds were confirmed by IR, 1 H-NMR, 13 C-NMR, MS, and elemental analysis. The newly synthesized compounds were tested against Bacillus subtilis and Staphylococcus aureus as Gram-positive bacteria, Escherichia coli and Pseudomonas aurignosa as Gram-negative bacteria, and Candida albicans and Aspergillus niger as fungi strains. Compounds 5a and b, 23, and 24 showed greater antimicrobial activity than the stranded compounds, suggesting that they could be considered as promising antimicrobial agents.Key words phthalazin-1-one; N-glycosylated phthalazinone; Schiff base; diazetedine; antimicrobial activity Phthalazines as N-heterocycles have received considerable attention in the literature as a consequence of their role as pharmacophore.1,2) Recently, they are derived from a wide range of biologically active natural products, troponoid family.3) A novel series of N-substituted-4-phenyl/benzylphthalazin-1-ones, phthalzine-1,4-dione showed antitumor activity. were prepared from the corresponding phthalazinones. Moreover, many substituted and fused phthalazine and phthalzinone derivatives exhibited antimicrobial activity. 23-26)On the basis of the above findings and in continuation of our research interest in the synthesis of novel biologically active heterocycles, [27][28][29][30][31] and with the aim of preparing new derivatives of phthalazine with potential pharmacological activity, we report here the synthesis of novel Schiff bases containing phthalazine moiety, phthalazinone and fused phthalazine derivatives, followed by evaluation of their antimicrobial activity against different strains of bacteria and fungi, where most of synthesized compounds exhibited a moderate to a strong antimicrobial activities. Some of the tested compounds showed antimicrobial activity higher than the reference compounds. Results and D...

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Section: Resultsmentioning

confidence: 99%

Facile Synthesis, Characterization, and Antimicrobial Evaluation of Novel Heterocycles, Schiff Bases, and <i>N</i>-Nucleosides Bearing Phthalazine Moiety

Azab

Rizk

Mahmoud

2016

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Elemental silver and silver salts have been used as antimicrobial agents for a long time. Silver nanoparticles (Ag-NPs) are one of the most commonly used nanoparticles, most particularly serving as an antimicrobial agent for medical applications (Kandile et al, 2010). In fact, nanosilver is a new class of material with different physiochemical and biological characteristics such as increased optical, electromagnetic, catalytic properties and antimicrobial activity from the bulk materials.…”

Section: The Effect Of Silver Nano Particle On Microorganismmentioning

confidence: 99%

A Review of Destructive Effect of Nano Silver on Human Health, Environment and Animals

Gavanji¹,

Larki²,

Mehrasa³

2013

IJSRES

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Abstract. Silver nanoparticles (AgNPs) are gaining attention from the academic and regulatory communities, not only because of their antimicrobial effects and subsequent product applications, but also because of their potential health and environmental risks. Nano-silver is used in an increasing number of products. Some of the applications have resulted in the concern of governments and the public, since little is known about the potential risks of nano-silver. It is hypothesized that the toxic effects of nano-silver are due to a combination of the specific properties of silver nanoparticles and the generation of ions from them. The main issue for future investigation is confirmation of our ‗0-hypothesis' that toxic effects of nano-silver are proportional to the activity of free silver ions which are released by the nanoparticles.

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“…Microwave technology is particularly suitable for the rapid and automated production of heterocyclic libraries [24][25][26][27][28][29][30] . In this study, we have synthesized hydrazine derivatives and three different classes of bis-Schiff bases.…”

Section: Chemistrymentioning

confidence: 99%

“…Hence it was considered that combinations of indole and 1,2,4-triazole structures might provide more potent pesticides 23 . In continuation of our studies on the synthesis and evaluation of biological activity of new heterocycles [24][25][26][27][28][29][30] , we report herein the efficient synthesis of new hydrazones, and Schiff bases based on the indole moiety and the evaluation of their biological activity as antimicrobial and anticancer agents.…”

Section: Introductionmentioning

confidence: 99%

Synthesis andin vitrobiological evaluation of new heterocycles based on the indole moiety

Kandile

Mohamed

Ismaeel

2014

Journal of Enzyme Inhibition and Medicinal Chemistry

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New compounds based on the indole moiety were synthesized via the reaction of indole-3-carbinal 1 with different nucleophiles such as 6-aryl-[4-(2-methoxybenzyl)pyridazin-3-yl] hydrazones 2a-c, benzidine, 3,3 0 -dimethoxybenzidine 4a,b and 2,6-diaminopyridine 6 to afford hydrazine derivatives 3a-c and three different classes of bis-Schiff bases. The structures of the new compounds were elucidated on the basis of their FTIR, 1 H NMR, 13C NMR spectral data, GC/MS and elemental analysis. The antimicrobial activity of the new compounds was evaluated using a broth dilution technique in terms of minimal inhibitory concentration (MIC) against four pathogenic bacteria and two pathogenic fungi strains. Compound 14b showed excellent activity against Escherichia coli and Klebsiella pneumoniae. Some of the prepared compounds were tested for anti-cancer activity against human cell lines HCT116 (colon), MCF7 (breast) and HELA (cervix). From the results of the in vitro assays, compounds 3a,b, and 18a,c presented promising anti-cancer activity.

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Silver Nanoparticles Effect on Antimicrobial and Antifungal Activity of New Heterocycles

Cited by 44 publications

References 36 publications

Facile Synthesis, Characterization, and Antimicrobial Evaluation of Novel Heterocycles, Schiff Bases, and <i>N</i>-Nucleosides Bearing Phthalazine Moiety

Facile Synthesis, Characterization, and Antimicrobial Evaluation of Novel Heterocycles, Schiff Bases, and <i>N</i>-Nucleosides Bearing Phthalazine Moiety

A Review of Destructive Effect of Nano Silver on Human Health, Environment and Animals

Synthesis andin vitrobiological evaluation of new heterocycles based on the indole moiety

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