Novel potential Centella asiatica extract in ameliorating neurotoxicity induced oxidative stress in chronic morphine dependant rat model

Halim, Shariff; Jasmi, Nor Amira; Ridzuan, P.M.; Anna, Deborah; Abdullah, Sarah; Sina, Thur

doi:10.5958/0974-4614.2020.00050.9

Cited by 6 publications

(6 citation statements)

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“…Various factors such as geographical area, plant growth and ecological conditions and type of plant sample preparation are the most important factors involved in the difference in the level of the antioxidant activity [21].The antioxidant properties of medicinal plants have been studied in various studie [32][33][34][35][36][37][38]. The reason for their antioxidant properties is the presence of secondary phenolic compounds, flavonoids and other compounds [39][40][41][42][43][44].…”

Section: Discussionmentioning

confidence: 99%

Determination and Evaluating the Antioxidant Properties of Ziziphus nummularia (Burm.f.) Wight & Arn., Crataegus pontica K.Koch and Scrophularia striata Boiss

Dokhani

Nazer²,

skokri³

et al. 2022

Egyptian Journal of Veterinary Sciences

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R ESEARCHERS have shown an increasing attention to the use of medicinal plants because of their beneficial effect on human health. The antioxidant properties of medicinal plants is a strong reason to use them in the food and pharmaceutical industries. Hence, the aim of this study was to evaluate the antioxidant properties of Ziziphus nummularia, Crataegus pontica and Scrophularia striata. Aerial parts of Ziziphus nummularia, Crataegus pontica and Scrophularia striata were dried and ground. Then, plant samples were prepared using homogenizing plant powders in methanol solution. Finally, the total antioxidant capacity of the plants was assessed by ferric iron reducing antioxidant power (FRAP) assay.The results indicated that the total antioxidant capacity was found as 3.16, 2.95 and 1.14 mmol Fe 2+ /L for Ziziphus nummularia, Crataegus pontica and Scrophularia striata, respectively. According to our results, Ziziphus nummularia, Crataegus pontica and Scrophularia striata showed a potent antioxidant activity. It is recommended that utilization of Ziziphus nummularia, Crataegus pontica and Scrophularia striata in food and pharmaceutical industries could possibly possess beneficial health effects.

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Section: Discussionmentioning

confidence: 99%

Determination and Evaluating the Antioxidant Properties of Ziziphus nummularia (Burm.f.) Wight & Arn., Crataegus pontica K.Koch and Scrophularia striata Boiss

Dokhani

Nazer²,

skokri³

et al. 2022

Egyptian Journal of Veterinary Sciences

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“…The overgeneration of reactive oxygen species (ROS) is a major cause of tissue injury and other biological disorders, such as morphine addiction. 33 Antioxidants can effectively decrease oxidative stress. 34,35 It has been shown that the over-production of ROS in testicles may cause mitochondrial dysfunction, and ultimately lead to testicular injury and apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…The overgeneration of reactive oxygen species (ROS) is a major cause of tissue injury and other biological disorders, such as morphine addiction 33 . Antioxidants can effectively decrease oxidative stress 34,35 .…”

Section: Discussionmentioning

confidence: 99%

Protective effect of remote ischemic postconditioning in rat testes after testicular torsion/detorsion

Liu

Yan

et al. 2022

Andrology

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Background: Testicular torsion/detorsion can lead to severe testicular damage.The organ-protective effect of remote ischemic postconditioning (RLIPost) against ischemia/reperfusion injury has been characterized; however, it remains unknown whether RLIPost has a testicular protective effect.Objectives: Here, we tested the hypothesis that RLIPost can protect the testes in a rat model of testicular torsion/detorsion in vivo. Materials and methods:Male Sprague-Dawley rats were assigned to sham-operated, control, or remote liver and limb ischemic postconditioning-treated groups. Testicular torsion/detorsion was performed by 3 h of testicular torsion (720 • clockwise unilateral spermatic cord torsion), followed by 3 h of detorsion. For liver and limb ischemic postconditioning, four cycles of 5 min of liver or limb ischemia with 5-min intermittent reperfusion stimuli were conducted at the onset of testicular reperfusion.Results: Liver and limb ischemic postconditioning significantly ameliorated ipsilateral and contralateral testicular swelling responses, preserved morphological integrity and spermatogenesis and inhibited testicular apoptosis. In addition, RLIPost enhanced the phosphorylation of AKT/ERK1/2/GSK-3β/STAT-3 in the ipsilateral testis while suppressing JNK activation in the ipsilateral and contralateral testes. Discussion and conclusion:To the best of our knowledge, this study is the first to demonstrate the involvement of RLIPost in an animal model of testicular torsion/detorsion. We showed that RLIPost protects both ipsilateral and contralateral testes against testicular torsion/detorsion in vivo, via at least in part, the RISK and SAFE-mediated signaling pathways.

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“…These disorders are the leading cause of mortality and disability, with more than three-quarters reported from developing countries 1,2 . Development of tools, guidelines, and designing models based on the prediction factors was conducted to prevent and control CVDs [3][4][5] . Several comorbidities and genetic and biochemical factors have been considered in the prediction systems of CVDs 6,7 .…”

Section: Introductionmentioning

confidence: 99%

“…Several comorbidities and genetic and biochemical factors have been considered in the prediction systems of CVDs 6,7 . Some adipose tissue biomarkers including adipokines have been hypothesized as the predictive factors of the occurrence of CVDs 5,8,9 . Previous reports revealed the probable role of omentin-1 as the established adipokines of atherosclerosis in healthy men and in patients with type 2 diabetes mellitus (T2DM) [10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

Omentin-1 circulating levels as predictor of heart diseases: a systematic review and meta-analysis

Wang

Zhuo

Jiang

2022

Rev. Assoc. Med. Bras.

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Novel potential Centella asiatica extract in ameliorating neurotoxicity induced oxidative stress in chronic morphine dependant rat model

Cited by 6 publications

References 0 publications

Determination and Evaluating the Antioxidant Properties of Ziziphus nummularia (Burm.f.) Wight & Arn., Crataegus pontica K.Koch and Scrophularia striata Boiss

Determination and Evaluating the Antioxidant Properties of Ziziphus nummularia (Burm.f.) Wight & Arn., Crataegus pontica K.Koch and Scrophularia striata Boiss

Protective effect of remote ischemic postconditioning in rat testes after testicular torsion/detorsion

Omentin-1 circulating levels as predictor of heart diseases: a systematic review and meta-analysis

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