Omentin-1 circulating levels as predictor of heart diseases: a systematic review and meta-analysis

Wang, Jijun; Zhuo, Xiaoqing; Jiang, Zhiyong

doi:10.1590/1806-9282.20211111

Cited by 5 publications

(3 citation statements)

References 36 publications

(34 reference statements)

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“…A systematic review and meta-analysis found that omentin concentrations are significantly lower in patients with cardiovascular disorders, including HF and cardiomyopathy. 32 In contrast, it has been shown that high omentin concentrations are related to increased LV volumes and cardiac dysfunction in patients with heart failure. 33 According to the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study, omentin was not associated with heart failure risk in the overall study population, but the association between omentin and heart failure risk depended on the presence or absence of CAD.…”

Section: Discussionmentioning

confidence: 99%

Omentin Modulates Chronic Cardiac Remodeling After Myocardial Infarction

et al. 2023

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Background: Omentin, a circulating adipokine, is downregulated in complications of obesity, including heart disease. Here, we investigated whether omentin modulates adverse cardiac remodeling in mice after myocardial infarction (MI). Methods and Results:Transgenic mice expressing the human omentin gene in fat tissue (OMT-Tg) and wild-type (WT) mice were subjected to permanent ligation of the left anterior descending coronary artery (LAD) to induce MI. OMT-Tg mice had a higher survival rate after permanent LAD ligation than WT mice. Moreover, OMT-Tg mice had lower heart weight/body weight (HW/BW) and lung weight/body weight (LW/BW) ratios at 4 weeks after coronary artery ligation compared with WT mice. OMT-Tg mice also showed decreased left ventricular diastolic diameter (LVDd) and increased fractional shortening (%FS) following MI. Moreover, an increase in capillary density in the infarct border zone and a decrease in myocardial apoptosis, myocyte hypertrophy, and interstitial fibrosis in the remote zone following MI, were more prevalent in OMT-Tg than WT mice. Finally, intravenous administration of adenoviral vectors expressing human omentin to WT mice after MI resulted in decreases in HW/BW, LW/BW, and LVDd, and an increase in %FS. Conclusions:Our findings document that human omentin prevents pathological cardiac remodeling after chronic ischemia, suggesting that omentin represents a potential therapeutic molecule for the treatment of ischemic heart disease.

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Section: Discussionmentioning

confidence: 99%

Omentin Modulates Chronic Cardiac Remodeling After Myocardial Infarction

et al. 2023

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“…Omentin‐1 is a protein hormone specifically expressed in omental adipose tissue. It has important functions such as anti‐inflammatory, anti‐atherosclerosis, regulating fat metabolism, and improving insulin sensitivity 8,9 . Scholars have found that it is closely related to insulin resistance, diabetes, metabolic syndrome, and inflammatory response 10 .…”

Section: Introductionmentioning

confidence: 99%

“…It has important functions such as anti-inflammatory, anti-atherosclerosis, regulating fat metabolism, and improving insulin sensitivity. 8,9 Scholars have found that it is closely related to insulin resistance, diabetes, metabolic syndrome, and inflammatory response. 10 Omentin-1 is also considered to be an important hub connecting OSA and its complications such as diabetes, hypertension, obesity, and atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Association between omentin and obstructive sleep apnea: A meta‐analysis

She

Liu

Ren

et al. 2023

Clinical Respiratory J

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Background: Obstructive sleep apnea (OSA) can lead to multisystem and multiorgan damage, which has attracted widespread attention from scholars. The pathogenesis of OSA is complex, and obesity plays an important role. Adipokine is secreted by adipose tissue, and its abnormal expression may be closely related to OSA. The relationship between omentin (a novel adipokine) and OSA is controversial. This study focuses on the important role of omentin in OSA and explores whether it can be regarded as a new target for the diagnosis and treatment of OSA.Method: PubMed, Embase, Web of Science, the Cochrane library, WAN-FANG, VIP, and Chinese National Knowledge Infrastructure were systematically searched for retrieving eligible studies until May 2022. Documents were screened according to strict inclusion and exclusion criteria, and data were extracted using Excel spreadsheets. The quality of the literature was assessed using the Newcastle-Ottawa Scale. RevMan 5.3 and Stata 12.0 software were used in this meta-analysis for data synthesis.Result: A total of eight eligible studies with 23 databases involving 914 participants were included in this meta-analysis. Combined data indicated that omentin levels in OSA patients were lower than that in controls (standardized mean difference = À1.54, 95% confidence interval = À2.07 to À1.00, p < 0.001). According to the subgroup analysis results of different races, sample source, gender, and the severity of the disease, compared with that in the control group, the level of omentin in OSA patients was significantly lower.When conducting sensitivity analysis, the results of the study were less stable.Meta-analysis indicated that there was no publication bias in this study. The omentin levels were significantly lower in OSA patients. The findings suggest that omentin may be a potential marker for the diagnosis and treatment of OSA. However, the heterogeneity of this study is high, and more high-quality large-sample studies will be needed in the future.

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