Novel piperidinylpyrimidine derivatives as inhibitors of HIV-1 LTR activation

IR and ¹H NMR Spectral Studies of some 2-Amino-4-Isopropyl-6-Methoxy-N-Phenylpyrimidine-5-Carboxamides: Assessment of Substituent Effects

“…Pyrimidine derivatives form a component in a number of useful drugs and are associated with many biological and therapeutical activities [2]. Pyrimidine derivatives have been reported as anti-microbial [3], analgesic, anti-viral, anti-inflammatory [4], anti-HIV [5], anti-tubercular [6], anti-tumour [7], anti-malarial [8], cardiovascular [9] agents. Pyrimidine derivatives have been found to exhibit cytostatic [10][11][12], immune modulating [13,14] and antibacterial properties [15][16][17][18][19][20][21].…”

Synthesis and biological evaluation of novel series of aminopyrimidine derivatives as urease inhibitors and antimicrobial agents

“…Pyrimidine derivatives form a component in a number of useful drugs and are associated with many biological, pharmaceutical and therapeutical activities 18 . Condensed pyrimidine derivatives have been reported as antimicrobial 19 , analgesic 20 , antiviral, anti-inflammatory 21 , anti-HIV 22 , antitubercular 23 , antitumour 24 , antineoplastic 25 , antimalarial 26 , diuretic 27 and antiplatelet agents 28 . Like pyrimidines, carbazole compounds also exhibits diverse biological properties.…”

Synthesis and in-vitro studies of some new quinoline 1,3,4-thiadiazolo pyrimidin derivatives

“…It is known that many 1,3,4-thiadiazoles have biological activities like antibacterial [9], antimycobacterial [10], antimycotic [11], antifungal [12], antidepression [13], analgesic [14] and anti-inflammatory [15]. Nitrogen containing heterocyclic ring such as pyrimidine and its derivatives have been reported as anti-microbial [16], analgesic, anti-viral, anti-inflammatory [17], anti-HIV [18], anti-tubercular [19], anti-tumour [20], anti-neoplastic [21], anti-malarial [22], diuretic [23], cardiovascular [24] agents. Here in, we report a series of eight new quinoline associated 1,3,4-thiadiazolo pyrimidin derivatives.…”