Novel NGR anchored pullulan micelles for controlled and targeted delivery of doxorubicin to HeLa cancerous cells

Hassanzadeh, Farshid; Mahmoudi, Elahe; Varshosaz, Jaleh; Khodarahmi, Ghadam Ali; Rostami, Mahboubeh; Ghanadian, Mustafa; Dana, Nasim

doi:10.1007/s13726-018-0606-9

Cited by 6 publications

(3 citation statements)

References 55 publications

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“…They show great differences in recognizing target substrates . The role of binding peptides in inorganic materials and polymers is that of adhesives, while they are more amenable to precise targeting in biomacromolecules. , In recent years, there has been growing interest in the applications of these materials and binding peptides. − For example, binding peptides can impart a variety of functional groups on metal surfaces to promote the self-assembly of metal nanoparticles. ,− Much of existing research on metal-binding peptides focused on the change of interface conformation during the binding process. ,− Polypeptides combined with silica and iron oxide have been used to immobilize enzymes and drug molecules on magnetic nanoparticles . In addition, specific peptides can be used to recover molybdenum disulfide (MoS 2 ) by linking it to magnetic nanoparticles .…”

Section: Introductionmentioning

confidence: 99%

“…Antifreeze and antifouling peptides have been used as functional additives for food preservation and sewage treatment, respectively. , The combination of binding peptides and biomolecules is mostly used for medical diagnosis and treatment, such as targeting, , sensing, imaging, and transmission . Recent studies have highlighted the significance of binding peptides in various fields, such as anchoring cancer cell antigens, synthesizing peptide-based fluorescent chemical sensors, and establishing carbon nanotube nucleic acid drug delivery systems. , …”

Section: Introductionmentioning

confidence: 99%

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Applications of Material-Binding Peptides: A Review

Ruan

Sohail

Zhao

et al. 2022

ACS Biomater. Sci. Eng.

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Material-binding peptides (MBPs) are functionalized adhesive materials consisting of a few to several dozen amino acids. This affinity between MBPs and materials is regulated by multiple interactions, including hydrogen bonding, electrostatic, hydrophobic interactions, and π–π stacking. They show selective binding and high affinity to a diverse range of inorganic and organic materials, such as silicon-based materials, metals, metal compounds, carbon materials, and polymers. They are used to improve the biocompatibility of materials, increase the efficiency of material synthesis, and guide the controlled synthesis of nanomaterials. In addition, these can be used for precise targeting of proteins by conjugating to target biomolecules. In this review, we summarize the main designs and applications of MBPs in recent years. The discussions focus on more efficient and functional peptides, including evolution and overall design of MBPs. We have also highlighted the recent applications of MBPs, such as functionalization of material surfaces, synthesis of nanomaterials, drug delivery, cancer therapy, and plastic degradation. Besides, we also discussed the development trend of MBPs. This interpretation will accelerate future investigations to bottleneck the drawbacks of available MBPs, promoting their commercial applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Applications of Material-Binding Peptides: A Review

Ruan

Sohail

Zhao

et al. 2022

ACS Biomater. Sci. Eng.

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“…Many polysaccharides can be chemically functionalized for optimized drug delivery [13,18] and they can be formulated as macroscopic implants [19,20], gels [21] and nanosized formulations [22]. In most studies, drugs have been physically encapsulated into the polysaccharide formulations, such as polymeric micelles or nanoparticles [13,[23][24][25], whereas chemical covalent conjugation technologies have not been applied for ocular in vivo drug delivery with polysaccharides. Recently, the chemical conjugation through hydrazone bond was used to generate peptide-dexamethasone and pullulan-dexamethasone conjugates that were investigated in vitro [10,26].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Pullulan–Dexamethasone Conjugates in Retinal Drug Delivery

et al. 2021

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The treatment of retinal diseases by intravitreal injections requires frequent administration unless drug delivery systems with long retention and controlled release are used. In this work, we focused on pullulan (≈67 kDa) conjugates of dexamethasone as therapeutic systems for intravitreal administration. The pullulan–dexamethasone conjugates self-assemble into negatively charged nanoparticles (average size 326 ± 29 nm). Intravitreal injections of pullulan and pullulan–dexamethasone were safe in mouse, rat and rabbit eyes. Fluorescently labeled pullulan particles showed prolonged retention in the vitreous and they were almost completely eliminated via aqueous humor outflow. Pullulan conjugates also distributed to the retina via Müller glial cells when tested in ex vivo retina explants and in vivo. Pharmacokinetic simulations showed that pullulan–dexamethasone conjugates may release free and active dexamethasone in the vitreous humor for over 16 days, even though a large fraction of dexamethasone may be eliminated from the eye as bound pullulan–dexamethasone. We conclude that pullulan based drug conjugates are promising intravitreal drug delivery systems as they may reduce injection frequency and deliver drugs into the retinal cells.

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