Advances in drug delivery and biomedical applications of hydroxyapatite-based systems: a review

Mashak, Arezou; Bazraee, Saeed; Mobedi, Hamid

doi:10.1007/s12034-022-02758-6

Cited by 7 publications

(3 citation statements)

References 157 publications

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“…Bioactive ceramics hydroxyapatites coatings on metallic implants [177][178][179] fluorapatite-based composites bone applications [180] bioactive glasses bone substitute and drug carrier [181] bioactive glass ceramics chemo hyperthermia [182] Biodegradable (bioresorbable)ceramics aluminium-calcium phosphate biomedical application [183] zinc-calcium phosphorous oxides postoperative tumour treatment [184] zinc-sulfate-calcium phosphates tissue engineering [185] ferric-calcium phosphorous oxides scaffolding for cell and drug delivery [186] coralline drugs [187] calcium aluminates bioactive dental materials [188] Bioinert (nonresorbable) ceramics alumina drug delivery [189] zirconia biomedical applications [190] carbons biomedical applications for tissue engineering [191] silicon nitride biomedical applications in medical implants [192]…”

Section: Bioceramics Examples Applications Referencesmentioning

confidence: 99%

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Chelu,

Musuc

2023

Processes

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Biomaterials are mostly any natural and synthetic materials which are compatible from a biological point of view with the human body. Biomaterials are widely used to sustain, increase, reestablish or substitute the biological function of any injured tissue and organ from the human body. Additionally, biomaterials are uninterruptedly in contact with the human body, i.e., tissue, blood and biological fluids. For this reason, an essential feature of biomaterials is their biocompatibility. Consequently, this review summarizes the classification of different types of biomaterials based on their origin, as natural and synthetic ones. Moreover, the advanced applications in pharmaceutical and medical domains are highlighted based on the specific mechanical and physical properties of biomaterials, concerning their use. The high-priority challenges in the field of biomaterials are also discussed, especially those regarding the transfer and implementation of valuable scientific results in medical practice.

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Section: Bioceramics Examples Applications Referencesmentioning

confidence: 99%

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Chelu,

Musuc

2023

Processes

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Section: ■ Introductionmentioning

confidence: 99%

“…HA, the main inorganic mineral component of teeth and bones, is a nontoxic, nonallergenic, nonmutagenic, osteoconductive material widely applied in implants, regenerative medicine, and drug delivery. , From the thermodynamic view of point, HA exhibits the highest level of chemical stability among the calcium phosphate compounds. , Nevertheless, current synthetic HA lacks sufficient interfacial bioactivity and antibacterial properties, requiring bioactive modifications to act as bone implants. , Meanwhile, as for drug delivery applications, the absence of nonfouling capacity compromises the use of HA as a drug carrier with long circulation, leading to suboptimal drug bioavailability. , Hence, it is crucial to develop a flexible surface modification platform based on the physicochemical properties of HA substrates. Our previous study introduced an approach for producing a PEGylated functionalized graft copolymer, which employed the coordination of nitrodopamine (ND) in conjunction with the electrostatic attraction of protonated amino (NH 3 + ) to anchor to HA.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Adsorption Stability and Biofunction Durability with Phosphonate-Grafted, PEGylated Copolymer on Hydroxyapatite Surface

Guo,

You,

Zhang

et al. 2024

Langmuir

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Nonfouling surfaces are crucial in applications such as biosensors, medical implants, marine coatings, and drug delivery vehicles. However, their long-term coating stability and robust surface binding strength in physiological media remain challenging. Herein, a phosphonate-grafted, PEGylated copolymer on the hydroxyapatite (HA) surface is proposed to significantly improve the adsorption stability and thus enhance the biofunction durability accordingly. The phosphoryl (−PO 3 ) grafted branch is employed in the functional polymer to facilitate attaching to the HA substrate. In addition, the polymer integrates the nonfouling polymer brushes of poly(ethylene glycol) (PEG) with the cell-adhesive moiety of cyclic Arg-Gly-Asp-D-Phe-Cys peptides (cRGD). A systematic study on the as-synthesized PEGylated graft copolymer indicates a synergistic binding mechanism of the NH 2 and PO 3 groups to HA, achieving a high surface coverage with desirable adsorption stability. The cRGD/PEGylated copolymers of optimized grafting architecture are proven to effectively adsorb to HA surfaces as a self-assembled copolymer monolayer, showing stability with minimal desorption even in a complex, physiological medium and effectively preventing nonspecific protein adsorption as examined with X-ray photoelectron spectroscopy (XPS) and a quartz crystal microbalance with dissipation (QCM-D). Direct adhesion assays further confirm that the enhanced coating stability and biofunction durability of the phosphonate-grafted, cRGD-PEGylated copolymer can considerably promote osteoblast attachment on HA surfaces, meanwhile preventing microbial adhesion. This research has resulted in a solution of self-assembly polymer structure optimization that exhibits stable nonfouling characteristics.

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Preparation and biological studies of chinese propolis essential oil-loaded chitosan/hydroxyapatite biomimetic material

Xu,

Ji,

Wei

et al. 2023

Food Measure

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Advances in drug delivery and biomedical applications of hydroxyapatite-based systems: a review

Cited by 7 publications

References 157 publications

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Enhanced Adsorption Stability and Biofunction Durability with Phosphonate-Grafted, PEGylated Copolymer on Hydroxyapatite Surface

Preparation and biological studies of chinese propolis essential oil-loaded chitosan/hydroxyapatite biomimetic material

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