Applications of Material-Binding Peptides: A Review

Abstract

Material-binding peptides (MBPs) are functionalized adhesive materials consisting of a few to several dozen amino acids. This affinity between MBPs and materials is regulated by multiple interactions, including hydrogen bonding, electrostatic, hydrophobic interactions, and π–π stacking. They show selective binding and high affinity to a diverse range of inorganic and organic materials, such as silicon-based materials, metals, metal compounds, carbon materials, and polymers. They are used to improve the biocompatibility of materials, increase the efficiency of material synthesis, and guide the controlled synthesis of nanomaterials. In addition, these can be used for precise targeting of proteins by conjugating to target biomolecules. In this review, we summarize the main designs and applications of MBPs in recent years. The discussions focus on more efficient and functional peptides, including evolution and overall design of MBPs. We have also highlighted the recent applications of MBPs, such as functionalization of material surfaces, synthesis of nanomaterials, drug delivery, cancer therapy, and plastic degradation. Besides, we also discussed the development trend of MBPs. This interpretation will accelerate future investigations to bottleneck the drawbacks of available MBPs, promoting their commercial applications.

Mild Method for Deprotection of the N-Benzyloxycarbonyl (N-Cbz) Group by the Combination of AlCl3 and HFIP

“…Interestingly, no racemization was observed, as evidenced by 1 H NMR analysis. In recent times, oligo- and polypeptide molecules have gained popularity as the most sought-after biomolecules in drug discovery and material science research . Therefore, a range of peptide molecules were prepared using commercially available chiral N -Cbz amino acids with chiral amino esters to check the applicability of the AlCl 3 /HFIP method.…”

Ein modifiziertes Ankerpeptid LCI mit einem Cobalt‐Cofaktor verbessert die Oxidationseffizienz von Polystyrol‐Mikropartikeln

“…Ankerpeptide (APs) sind vielseitige Adhäsionspeptide, die mit einer Vielzahl von Oberflächen wechselwirken können, einschließlich von Edelstahl‐ und Polymeroberflächen, [12] und zwar durch zahlreiche nicht‐kovalente Wechselwirkungen wie elektrostatische, polare, hydrophobe und Wasserstoffbrückenbindungen [13–15] . Wie bereits gezeigt wurde, bindet das β‐Faltblatt‐Ankerpeptid LCI (“liquid chromatography peak I”) spezifisch und effizient an etliche Polymeroberflächen wie Polystyrol unter milden Bedingungen [16–24] .…”

Construction and reconfiguration of dynamic DNA origami assemblies with coiled-coil patches and patterns

“…Furthermore, as a step towards integrating the advantages of DNA-based assemblies with amino acid materials, we combined the structure and dynamic properties of DNA origami devices with the tunable interactions of peptides (29,30). Peptides have a number of useful properties such as biocompatibility (31); well-established approaches for sequence design (32) and synthesis (33), specific binding and self-assembly capabilities (34), and an existing basis for stimulus-responsive motifs (35). Here, we leverage the specific binding interactions of coiled-coil peptides.…”