Novel nanohydrogel based on itaconic acid grafted tragacanth gum for controlled release of ampicillin

Pathania, Deepak; Verma, Chetna; Negi, Poonam; Tyagi, Inderjeet; Asif, Mohammad; Kumar, Nadavala Siva; Al‐Ghurabi, Ebrahim H.; Agarwal, Shilpi; Gupta, Vinod Kumar

doi:10.1016/j.carbpol.2018.05.040

Cited by 64 publications

(41 citation statements)

References 44 publications

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“…All samples show identical trend in swelling pattern where initially it increases rapidly and reaches saturation within 3 h. An increase in swelling with degree of grafting is a reflection of the enhanced hydrophilicity of the grafted matrix due to the increase in the carboxyl functionality within the grafted matrix. This is the pattern that has been observed by several groups working in this field . The pH‐sensitivity of GTG is presented in Fig.…”

Section: Resultssupporting

confidence: 78%

“…Graft copolymers have been developed for metal ion separation using monomers such as acrylonitrile and acrylic acid to create sites for metal binding . TG hydrogels grafted with acrylic acid and acrylamide have been used for drug delivery applications . Itaconic acid (IA) has a bifunctional nature containing two carboxyl groups.…”

Section: Introductionmentioning

confidence: 99%

“…This has attracted polymer scientists to develop polymers with carboxyl functionality for bonding with various other moieties . Our recent studies on the grafting of IA on TG were undertaken using microwave initiation leading to relatively high graft levels for controlled drug delivery . However, it seems that the microwave approach may not be attractive enough for the formulation of pH‐sensitive smart materials as evident from the outcome of drug release at a pH of 2.5 and 7.4.…”

Section: Introductionmentioning

confidence: 99%

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Preparation of pH‐sensitive hydrogels by graft polymerization of itaconic acid on tragacanth gum

Verma

Negi

Pathania

et al. 2018

Polymer International

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Graft polymerization of itaconic acid on tragacanth gum (TG) was carried out using potassium persulfate as initiator to develop smart hydrogels for drug delivery systems. The effect of the grafting parameters on the degree of grafting was investigated. The grafting was significantly influenced by the reaction medium, the reaction temperature and the monomer concentration. The monomer dependency of the system was found to be 1.52. The hydrogels were characterized using Fourier transform infrared spectroscopy, thermogravimetric analysis, differential scanning calorimetry and X‐ray diffraction. The grafted TG had an amorphous nature and exhibited excellent swelling in water and strong dependence on the pH of the medium. The grafted TG showed pH‐dependent release of ciprofloxacin which offers the possibility of using these materials in colon‐specific drug targeting for human healthcare systems. © 2018 Society of Chemical Industry

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Section: Resultssupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preparation of pH‐sensitive hydrogels by graft polymerization of itaconic acid on tragacanth gum

Verma

Negi

Pathania

et al. 2018

Polymer International

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“…Super paramagnetic TG nanogels were designed by sol-gel process for the controlled release of quercetin in which Fe3O4-SiO2 nanoparticles as a magnetic core and N-vinyl imidazole as the functional monomer [16]. Recently, we reported the microwave assisted synthesis of polyitaconic acid grafted TG based nanohydrogels for controlled release of ampicillin [17].…”

Section: Introductionmentioning

confidence: 99%

Preparation of novel tragacanth gum-entrapped lecithin nanogels

Verma¹,

Negi²,

Pathania³

et al. 2019

Adv. Mater. Lett.

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Nanogel synthesis is gaining enormous interest in a large number of applications, such as drug delivery, wound care systems and tissue engineering. In the present work, we have investigated the preparation of Tragacanth gum (TG) nanoparticles in a water-in-oil nanoemulsion system. These nanoparticles exhibit stacked core-shell type of structure in which polygonal TG nanoparticles are covered by lipid structured lecithin (LC). The resultant nanoparticles comprise of amphillic nature, i.e. the hydrophilic TG core and hydrophobic LC shell which offers interesting features of immobilization of biomolecules.

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“…They also allow diffusion of entrapped molecules into the outer medium. Due to these properties, they have found applications in biomedicine, pharmacy, and in cleaning of the contaminated water and soil …”

Section: Introductionmentioning

confidence: 99%

Photoinitiated synthesis of poly(poly(ethylene glycol) methacrylate‐co‐diethyl amino ethyl methacrylate) superabsorbent hydrogels for dye adsorption

Alokour

Yilmaz

2019

J of Applied Polymer Sci

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Random copolymers of poly(ethylene glycol) methacrylate (PEGM), and diethyl amino ethyl methacrylate (DEAEM) were synthesized at low, and high conversions by photoinitiation. Crosslinked poly(PEGM‐co‐DEAEM) samples were obtained, and characterized by FTIR, SEM, DSC, TGA, and elemental analyses. Swelling behavior of the copolymers revealed that the copolymers acted as superabsorbent hydrogels. The monomer reactivity ratios were calculated using Fineman Ross, Extended Kelen Tüdøs, and Mayo Lewis methods that gave r1(PEGM) = 0.90, r2(DEAEM) = 0.14 at low conversions. At high conversions r1 and r2 values were calculated as 1.01 and 0.40, respectively. Adsorption isotherms of methyl orange (MO) onto hydrogels were studied using Langmuir, Freundlich, and Temkin models. The experimental data fitted well with the Langmuir equation. The maximum adsorption capacity for MO was 212.7 mg g−1 at pH = 3. The adsorption data gave best fit with the pseudo‐second order kinetic model. Thermodynamic evaluation showed spontaneous nature for MO adsorption onto poly(PEGM‐co‐DEAEM) hydrogels. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47707.

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Novel nanohydrogel based on itaconic acid grafted tragacanth gum for controlled release of ampicillin

Cited by 64 publications

References 44 publications

Preparation of pH‐sensitive hydrogels by graft polymerization of itaconic acid on tragacanth gum

Preparation of pH‐sensitive hydrogels by graft polymerization of itaconic acid on tragacanth gum

Preparation of novel tragacanth gum-entrapped lecithin nanogels

Photoinitiated synthesis of poly(poly(ethylene glycol) methacrylate‐co‐diethyl amino ethyl methacrylate) superabsorbent hydrogels for dye adsorption

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