Novel Metal Polyphenol Framework for MR Imaging-Guided Photothermal Therapy

Abstract

Phothermal therapy has received increasing attention in recent years as a potentially effective way to treat cancer. In pursuit of a more biocompatible photothermal agent, we utilize biosafe materials including ellagic acid (EA), polyvinylpyrrolidone (PVP), and iron element as building blocks, and we successfully fabricate a homogeneous nanosized Fe-EA framework for the first time by a facile method. As expected, the novel nanoagent exhibits no obvious cytotoxicity and good hemocompatibility in vitro and in vivo. The microenvironment responsiveness to both pH and hydrogen peroxide makes the NPs biodegradable in tumor tissues, and the framework should be easily cleared by the body. Photothermal potentials of the nanoparticles are demonstrated with relevant features of strong NIR light absorption, moderately effective photothermal conversion efficiency, and good photothermal stability. The in vivo photothermal therapy also achieved effective tumor ablation with no apparent toxicity. On the other hand, it also exhibits T2 MR imaging ability originated from ferric ions. Our work highlights the promise of the Fe-EA framework for imaging-guided photothermal therapy.

Ultra‐small Albumin Templated Gd/Ru Composite Nanodots for In Vivo Dual modal MR/Thermal Imaging Guided Photothermal Therapy

“…31.9–37.9 °C ) for PBS‐injected mice (Figure b). Considerable hyperthermia for effectively ablation of tumor cells could easily be reached even at low concentrations of GRBNDs upon LASER irradiation based on the normal human body temperature of 37 °C . This distinguishable temperature profile also shows that our nanodots can serve as infrared thermography nanoagent …”

Metal–Organic Framework‐Based Stimuli‐Responsive Systems for Drug Delivery

“…pH/H 2 O 2 ‐Responsive: Fe‐EA : Zhao et al synthesized Fe‐EA nanoframework NPs by using the biosafe material ellagic acid (EA), polyvinylpyrrolidone (PVP), and ferric ions as building blocks. The amount of EA in this nano‐framework was determined to be 60 wt% based on the amount of the element Fe measured by inductively coupled plasma‐atomic emission spectrometry.…”

“…For example, a lot of researches have reported the in vitro toxicity of MOF NPs, but these in vitro experiments based on established cell lines are hardly reproduced in the in vivo situation; currently, only very few studies on the in vivo toxicity of MOF NPs have been performed . In addition, although there have been emerging reports on MOF NPs for in vivo cancer therapy, few of the delivery systems were MOFs‐based stimulus‐responsive NPs . Most of the studies on MOF‐based stimulus‐responsive NPs for drug delivery were still in the in vitro step, more systematic in vivo investigations should be carried out for preclinical evaluation.…”

Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

“…used Fe(III) and ellagic acid to fabricate MPNs with the help of PVP through a green synthetic method. [ 182 ] The obtained MPNs had satisfactory NIR absorption, excellent photothermal stability, and proper photothermal conversion efficiency. In addition, the in vivo PTT using the MPNs realized good anticancer performance with slight cytotoxicity.…”