Ultra‐small Albumin Templated Gd/Ru Composite Nanodots for In Vivo Dual modal MR/Thermal Imaging Guided Photothermal Therapy

Xu, Pengping; Wu, Huihui; Wang, Dongdong; Zhao, Guangtao; Li, Fenfen; Qiu, Bensheng; Guo, Zhen; Chen, Qianwang

doi:10.1002/adhm.201800322

Cited by 32 publications

(21 citation statements)

References 61 publications

(67 reference statements)

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“…For the blood routine analysis, indexes such as white blood cell (WBC), red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), platelets (PLT), mean corpuscular volume (MCV), mean platelet volume (MPV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were determined (Figure d–l). All nine indexes fell within the normal ranges, revealing negligible in vivo blood toxicity of MCOPP‐Ce6 at the treatment dose within 15 d . The histological analysis on the main organ tissues from mice sacrificed 15 d post‐treatment with MCOPP‐Ce6 via tail vein injection was also performed (Figure m).…”

Section: Methodsmentioning

confidence: 93%

A Mesoporous Nanoenzyme Derived from Metal–Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy

et al. 2019

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Photodynamic therapy (PDT), a wellknown clinical modality that involves photosensitizer, molecular oxygen (O 2 ), and excitation light to generate cytotoxic reactive oxygen species such as singlet oxygen ( 1 O 2 ), has been proven to be a selective method for treating a wide spectrum of localized and superficial cancers or other diseases. [1][2][3][4][5][6][7][8][9] In addition to destroying cancer cells through direct photodamage, PDT can also induce vascular damage in the tumor, and activate the response of immune system. [10][11][12][13] Possessing spatial and temporal control over the localization of the light irradiation, the O 2 -involved PDT can remarkably improve the selectivity and reduce the side effects when compared to other conventional modalities such as chemotherapy, surgery, and radiotherapy. [14][15][16] On the other hand, tumor hypoxia compromises therapeutic effect of PDT, as O 2 is an indispensable element during the process. Uncontrollable growth of tumor cells as well as dysregulated formation of tumor blood vessels inevitably result in the cancer hypoxia. [17,18] In addition, microvascular collapse caused by PDT would further compromise the O 2 supply and aggravate the hypoxia condition, thus preventing effective PDT of cancer. Consequently, a vicious circle occurs, as PDT not only consumes localized O 2 , but also cuts off the O 2 supply. [19][20][21] To date, three main strategies have been employed to overcome the pre-existing hypoxia and improve the therapeutic effect of PDT. The most popular approach relies on the integration of PDT with other therapeutic modalities for a synergistic therapy. [17,22,23] However, such complex structures are often costly, which limit their scalable production and reproducibility. Another strategy is the utilization of intelligent nanomaterials that can act as O 2 carriers for direct transportation of mole cular oxygen to tumor sites. For example, Hu and coworkers reported photosensitizer-loaded perfluorocarbon nanodroplets as an O 2 self-enriched PDT nanoplatform. [24] The last approach is to construct smart nanoplatforms for in situ generation of O 2 within solid tumors based on the characteristics Tumor hypoxia compromises the therapeutic efficiency of photodynamic therapy (PDT) as the local oxygen concentration plays an important role in the generation of cytotoxic singlet oxygen ( 1 O 2 ). Herein, a versatile mesoporous nanoenzyme (NE) derived from metal-organic frameworks (MOFs) is presented for in situ generation of endogenous O 2 to enhancethe PDT efficacy under bioimaging guidance. The mesoporous NE is constructed by first coating a manganese-based MOFs with mesoporous silica, followed by a facile annealing process under the ambient atmosphere. After removing the mesoporous silica shell and post-modifying with polydopamine and poly(ethylene glycol) for improving the biocompatibility, the obtained mesoporous NE is loaded with chlorin e6 (Ce6), a commonly used photosensitizer in PDT, with a high loading capacity. Upon the O 2 generation through the...

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Section: Methodsmentioning

confidence: 93%

A Mesoporous Nanoenzyme Derived from Metal–Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy

et al. 2019

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“…Meanwhile, the zeta potential of Te–Gd in aqueous solution is about −14.6 mV. To date, many groups have reported BSA‐bioinspired gadolinium‐based hybrid nanoparticles for cancer therapy, such as Gd:CuS@BSA, [ 40 ] Gd/Ru@BSA, [ 46 ] Gd 2 O 3 @BSA, [ 47 ] and Gd 2 O 3 /Bi 2 S 3 . [ 48 ] The aforementioned BSA‐bioinspired gadolinium‐based hybrid nanoparticles are featured with high biosafety, excellent biocompatibility, and satisfactory therapeutic outcomes.…”

Section: Resultsmentioning

confidence: 99%

Engineering Gadolinium‐Integrated Tellurium Nanorods for Theory‐Oriented Photonic Hyperthermia in the NIR‐II Biowindow

Dong

Wen

et al. 2020

Small

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Near‐infrared (NIR) light‐triggered hyperthermia has exhibited promising prospects in oncology therapy due to the unique merits including minimal invasiveness, monitorable, excellent therapeutic effect, and negligible side effects. Especially, the second NIR biowindow (NIR‐II, 1000–1700 nm) with less absorbance and scattering by skin tissue, and deep tissue penetration, has received extensive attention for photonic hyperthermia. Unfortunately, the dissatisfactory photothermal conversion efficiency (PCE) and cumbersome preparation process of photo‐driven heat conversion nanomaterials seriously hamper the future clinical application. To combat the aforementioned challenges, high imaging performance and desired therapeutic outcome 1D nanorods are constructed based on gadolinium‐integrated tellurium nanorods (Te–Gd). In this system, magnetic resonance (MR) imaging and X‐ray computed tomography (CT) imaging‐guided photonic hyperthermia can be easily implemented in cooperation with Te–Gd. Importantly, Te–Gd possesses high PCE (41%) in the NIR‐II biowindow because the transition of the excited electron can easily occur from the valence band (VB) to the conduction band (CB) on (1 0 1) and (1 0 2) crystal planes. Furthermore, the distinctive photostability, high tumor accumulation, as well as low systemic adverse effects of Te–Gd guarantee the potential in the clinic.

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“…[107] Based on biomimetic mineralization, Xu et al used a completely "green" and "one-pot" strategy to synthesize hybrid Gd/Ru@BSA nanodots (GRBND), with BSA as the template and the reducing agent. [108] The prepared uniform Gd/Ru@BSA nanodots had great properties including magnetic resonance imaging contrast, and high conversion efficiency ( = 50.7%) for photothermal imaging and therapy. The Gd/Ru@BSA nanodots possessed competitive longitudinal relaxivity (r 1 = 10.98 × 10 −3 m −1 s −1 ) for T1-weighted MRI, good colloidal, and high photothermal stability.…”

Section: Regulation Of Biomineralization By Protein Templatesmentioning

confidence: 99%

Biomineralization: An Opportunity and Challenge of Nanoparticle Drug Delivery Systems for Cancer Therapy

Wang

Liu

Zheng

et al. 2020

Adv Healthcare Materials

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Biomineralization is a common process in organisms to produce hard biomaterials by combining inorganic ions with biomacromolecules. Multifunctional nanoplatforms are developed based on the mechanism of biomineralization in many biomedical applications. In the past few years, biomineralization-based nanoparticle drug delivery systems for the cancer treatment have gained a lot of research attention due to the advantages including simple preparation, good biocompatibility, degradability, easy modification, versatility, and targeting. In this review, the research trends of biomineralization-based nanoparticle drug delivery systems and their applications in cancer therapy are summarized. This work aims to promote future researches on cancer therapy based on biomineralization. Rational design of nanoparticle drug delivery systems can overcome the bottleneck in the clinical transformation of nanomaterials. At the same time, biomineralization has also provided new research ideas for cancer treatment, i.e., targeted therapy, which has significantly better performance.

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Ultra‐small Albumin Templated Gd/Ru Composite Nanodots for In Vivo Dual modal MR/Thermal Imaging Guided Photothermal Therapy

Cited by 32 publications

References 61 publications

A Mesoporous Nanoenzyme Derived from Metal–Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy

A Mesoporous Nanoenzyme Derived from Metal–Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy

Engineering Gadolinium‐Integrated Tellurium Nanorods for Theory‐Oriented Photonic Hyperthermia in the NIR‐II Biowindow

Biomineralization: An Opportunity and Challenge of Nanoparticle Drug Delivery Systems for Cancer Therapy

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