Novel Green Approaches for the Preparation of Gold Nanoparticles and Their Promising Potential in Oncology

Abstract

The difficulty of achieving targeted drug delivery following administration of currently marketed anticancer therapeutics is a still a concern. Metallic nanoparticles (NPs) developed through nanotechnology breakthroughs appear to be promising in this regard. Research studies pertaining to gold NPs have indicated their promising applicability in cancer diagnosis, drug delivery and therapy. These NPs have also recently paved the path for precise drug delivery and site-specific targeting. Our review paper thus highlights the scope and impact of biogenetically generated gold nanoparticles (NPs) in cancer therapy. In a critical, constructive, and methodical manner, we compare the advantages offered by gold NPs over other metal NPs. Moreover, we also focus on novel ‘greener’ strategies that have been recently explored for the preparation of gold NPs and shed light on the disadvantages of conventional NP synthesis routes. Future prospects pertaining to the use of gold NPs in oncotherapy and domains that require further investigation are also addressed.

An Insight into Advances in Developing Nanotechnology Based Therapeutics, Drug Delivery, Diagnostics and Vaccines: Multidimensional Applications in Tuberculosis Disease Management

“…There are many different types of NPs, but they can be broken down into three broad categories: organic (fullerenes, graphene, and carbon nanotubes); inorganic (metal and metal oxide NPs such as silver, gold, iron oxide, zinc oxide, and silica); and inorganic (liposomes, dendrimers, micelles, and liposome-based NPs) [101]. Although research into the use of NPs in drug delivery has been extensive, inorganic NPs have been found to have advantages over their organic counterparts in terms of protection and bioavailability, thanks to their ability to provide targeted drug action, reduced adverse reactions in the organism, and increased drug transport and penetration [102][103][104][105][106].…”

Nanotechnology in the Diagnostic and Therapy of Hepatocellular Carcinoma

“…Gold nanoparticles (AuNPs) are, usually, synthesized by chemical reduction and stabilization using a capping agent, electrochemical deposition on electrode surfaces (in the case of nanoparticles-based electrochemical sensors), or newly emerging biological-synthesis techniques [ 10 , 25 ]. The resulting gold nanoparticles can be easily functionalized, can be used for hyperthermia applications, and can easily be controlled regarding their size and surface properties [ 11 ].…”

Insights on prospects of nano-siRNA based approaches in treatment of Cancer

“…Cancer can spread throughout organs in the body that differ from its primary site of origin, and is primarily caused through DNA (deoxyribose nucleic acid) mutations that occur intracellularly ( Bhattacharya et al, 2022 ). Cancer often disrupts cell-to-cell communication, resulting in crucial gene malfunction.…”