Nanotechnology in the Diagnostic and Therapy of Hepatocellular Carcinoma

Graur, Florin; Puia, Aida; Moiş, Emil; Moldovan, Septimiu; Pusta, Alexandra; Cristea, Cécilia; Cavalu, Simona; Puia, Cosmin; Hajjar, Nadim Al

doi:10.3390/ma15113893

Cited by 10 publications

(8 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Doxorubicin, sorafenib, and siRNA are often encapsulated in various types of liposomes. The main purpose of encapsulation is to protect the active drug from degradation by the immune system 96 , 98 . Numerous biological applications, particularly in the field of drug administration, have been made possible by the distinctive qualities of liposomes, such as biocompatibility, biodegradability, amphiphilicity, less toxic effects, non-ionicity, prolonged drug release, and site-specific action 96 , 99 .…”

Section: Different Nanoparticles Used In Nanotheranosticsmentioning

confidence: 99%

Interventional nanotheranostics in hepatocellular carcinoma

Chavda¹,

Balar²,

Patel³

2023

Nanotheranostics

View full text Add to dashboard Cite

Interventional nanotheranostics is a system of drug delivery that does a dual function; along with the therapeutic action, it also does have diagnostic features. This method helps in early detection, targeted delivery, and the least chances of damage to surrounding tissue. It ensures the highest efficiency for the management of the disease. Imaging is the near future for the quickest and most accurate detection of disease. After combing both effective measures, it ensures the most meticulous drug delivery system. Nanoparticles such as Gold NPs, Carbon NPs, Silicon NPS, etc. The article emphasizes on effect of this delivery system in the treatment of Hepatocellular Carcinoma. It is one of the widely spreading diseases and theranostics is trying to make the scenario better. The review suggests the pitfall of the current system and how theranostics can help. It describes the mechanism used to generate its effect and believes that interventional nanotheranostics do have a future with rainbow color. The article also describes the current hindrance to the flourishing of this miraculous technology.

show abstract

Section: Different Nanoparticles Used In Nanotheranosticsmentioning

confidence: 99%

Interventional nanotheranostics in hepatocellular carcinoma

Chavda¹,

Balar²,

Patel³

2023

Nanotheranostics

View full text Add to dashboard Cite

show abstract

“…Moreover, controlled release of drug-loaded NPs can protect drugs from rapid excretion and biodegradation, thus improving the pharmacokinetic parameters of drugs in vivo, promoting the enrichment of drugs in local tumor tissues, and improving the anticancer-targeting ability of drugs. Therefore, developing multifunctional nanocomposites with high drug loading efficacy, targeted delivery, sustained release, and imaging properties for TACE therapy of HCC is becoming a hot research topic in recent years [ 45 , 46 , 71 , 72 ]. As shown in Table 2 , apart from drug delivery, different kinds of nano-formulations possess diverse functions such as hyperthermia, embolization, imaging, etc., which are conducive to synergistic diagnosis or monitoring, and treatment of HCC.…”

Section: Rational Design Of Multifunctional Nanoplatforms For Tace Pr...mentioning

confidence: 99%

“…Although ablation, surgery, and liver transplantation are radical treatments for HCC, the outlook suggests that new nano-conditioned therapies based on TACE will be helpful in clinical practice [ 72 ]. Researchers have set the goal of developing nanoplatforms to apply nanomaterials in clinics so as to improve the efficacy of TACE in treating HCC and reduce systemic side effects.…”

Section: Research Status Of Nanomaterials For Tace Therapy In the Tre...mentioning

confidence: 99%

Multifunctional nanoplatforms application in the transcatheter chemoembolization against hepatocellular carcinoma

et al. 2023

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) has the sixth-highest new incidence and fourth-highest mortality worldwide. Transarterial chemoembolization (TACE) is one of the primary treatment strategies for unresectable HCC. However, the therapeutic effect is still unsatisfactory due to the insufficient distribution of antineoplastic drugs in tumor tissues and the worsened post-embolization tumor microenvironment (TME, e.g., hypoxia and reduced pH). Recently, using nanomaterials as a drug delivery platform for TACE therapy of HCC has been a research hotspot. With the development of nanotechnology, multifunctional nanoplatforms have been developed to embolize the tumor vasculature, creating conditions for improving the distribution and bioavailability of drugs in tumor tissues. Currently, the researchers are focusing on functionalizing nanomaterials to achieve high drug loading efficacy, thorough vascular embolization, tumor targeting, controlled sustained release of drugs, and real-time imaging in the TACE process to facilitate precise embolization and enable therapeutic procedures follow-up imaging of tumor lesions. Herein, we summarized the recent advances and applications of functionalized nanomaterials based on TACE against HCC, believing that developing these functionalized nanoplatforms may be a promising approach for improving the TACE therapeutic effect of HCC.

show abstract

“…27 In addition, there are ultra-small size NPs with nanoenzyme functions that have anti-inammatory, antioxidant and anti-tumor effects. [28][29][30][31] Although NPs-loaded drug therapy can increase its efficacy, the effect of single treatment remains mediocre. Multimodal diagnostics (using light, sound, heat, etc.)…”

Section: Introductionmentioning

confidence: 99%

“…27 In addition, there are ultra-small size NPs with nanoenzyme functions that have anti-inflammatory, antioxidant and anti-tumor effects. 28–31…”

Section: Introductionmentioning

confidence: 99%