Novel goose parvovirus in domestic Linwu sheldrakes with short beak and dwarfism syndrome, China

Wan, Chunhe; Liu, Rongchang; Chen, Cuiteng; Cheng, Longfei; Shi, Shaohua; Fu, Guanghua; Chen, Hongmei; Fu, Qiuling; Huang, Yu

doi:10.1111/tbed.13280

Cited by 15 publications

(15 citation statements)

References 14 publications

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“…whole genome 80.8-81.3% 94.1-94.4% 94.4-94.7% 97.7-97.9% 99.2-99.6% 95.5-95.9% 86.0-86.3% Rep sequence 82.3-82.9% 93.7-94.4% 95.9-96.4% 98.6-99.3% 99.0-99.9% 95.9-96.3% 82.6-83.2% Cap sequence 80.3-80.4% 95.3-95.5% 94.5-94.8% 96.2-96.6% 99.3-99.6% 96.0-96.3% 89.6-89.8% a. The MDPV FM strain of Muscovy duck parvovirus (MDPV), discovered in Hungary in 1993 by Zadori et al [6]; b. SYG61v strain (vaccine strain) of goose parvovirus (GPV); c. novel goose parvovirus-related virus (NGPV) strain SDLY1602 responsible for duck tongue disease, found in Shandong province in 2016 by Li et al [7]; d. GPV strain B isolated from grey goose in Hungary[6]; e. GPV-RC16 strain from Chongqing reported in 2017 by Liu et al[1,8]; f. the NGPV HuN18 strain of Novel goose parvovirus (NGPV), discovered in Hunan province in 2018 by Wan C et al[9]; g. MDPV strain JH10 isolated from Muscovy duck in China[10].…”

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confidence: 99%

Whole Genome Characterization and Genetic Evolution Analysis of a New Ostrich Parvovirus

Yuan

Wang²,

Luan

et al. 2020

Viruses

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Ostrich diseases characterized by paralysis have been breaking out in broad areas of China since 2015, causing major damage to the ostrich breeding industry in China. This report describes a parvovirus detected in ostriches from four different regions. The entire genomes of four parvovirus strains were sequenced following amplification by PCR, and we conducted comprehensive analysis of the ostrich parvovirus genome. Results showed that the length genomes of the parvovirus contained two open reading frames. Ostrich parvovirus (OsPV) is a branch of goose parvovirus (GPV). Genetic distance analysis revealed a close relationship between the parvovirus and goose parvovirus strains from China, with the closest being the 2016 goose parvovirus RC16 strain from Chongqing. This is the first report of a parvovirus in ostriches. However, whether OsPV is the pathogen of ostrich paralysis remains uncertain. This study contributes new information about the evolution and epidemiology of parvovirus in China, which provides a new way for the study of paralysis in ostriches.

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confidence: 99%

Whole Genome Characterization and Genetic Evolution Analysis of a New Ostrich Parvovirus

Yuan

Wang²,

Luan

et al. 2020

Viruses

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“…DuCV is an immunosuppressive virus that weakens the host's immune response and makes it susceptible to secondary infections. GPV has been widely studied as the pathogen of SBDS in recent years, however, the success rate for laboratory infection is only 20% to 35% at present (5,16,26). Addressing this problem, we investigated cases in the field and found a high coinfection rate of GPV and DuCV in ducks, especially in SBDS.…”

Section: Discussionmentioning

confidence: 94%

“…Epidemiological investigation showed that both the GPV and DuCV present in SBDS are common in duck flocks in East China (12). Though GPV was demonstrated as the pathogen of SBDS in ducks (20), the disease is rarely reproduced by experimental infection (5,16,26). It is unclear whether DuCV synergises with GPV, and affects the replication and pathogenicity of both viruses.…”

Section: Introductionmentioning

confidence: 99%

Effect of goose parvovirus and duck circovirus coinfection in ducks

Liu

Yang

Hao

et al. 2020

Journal of Veterinary Research

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IntroductionCoinfection of goose parvovirus (GPV) and duck circovirus (DuCV) occurs commonly in field cases of short beak and dwarfism syndrome (SBDS). However, whether there is synergism between the two viruses in replication and pathogenicity remains undetermined.Material and MethodsWe established a coinfection model of GPV and DuCV in Cherry Valley ducks. Tissue samples were examined histopathologically. The viral loads in tissues were detected by qPCR, and the distribution of the virus in tissues was detected by immunohistochemistry (IHC).ResultsCoinfection of GPV and DuCV significantly inhibited growth and development of ducks, and caused atrophy and pallor of the immune organs and necrosis of the liver. GPV and DuCV synergistically amplified pathogenicity in coinfected ducks. In the early stage of infection, viral loads of both pathogens in coinfected ducks were significantly lower than those in monoinfected ducks (P < 0.05). With the development of the infection process, GPV and DuCV loads in coinfected ducks were significantly higher than those in monoinfected ducks (P < 0.05). Extended viral distribution in the liver, kidney, duodenum, spleen, and bursa of Fabricius was consistent with the viral load increases in GPV and DuCV coinfected ducks.ConclusionThese results indicate that GPV and DuCV synergistically potentiate their replication and pathogenicity in coinfected ducks.

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“…Many other viruses can also cross species barriers, including parvoviruses and circoviruses. Parvoviruses have been found in geese, ducks, and canines, and circoviruses have been found in ducks, swine and canines [ 19 , [33] , [34] , [35] , [36] , [37] ].…”

Section: Discussionmentioning

confidence: 99%

“…According to a previous study, GPV can infect only geese and Muscovy ducks, but not other species of ducks [ 15 ]; however, the novel goose parvovirus (NGPV) was recently identified and was shown to be capable of infecting Cherry Valley ducks (Pekin ducks) [ [16] , [17] , [18] ]. The clinical symptoms caused by GPV include lethargy, stunting, anorexia, locomotor dysfunction, and watery diarrhea, which can lead to high mortality in geese and ducks that are less than one month old [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous detection of duck circovirus and novel goose parvovirus via SYBR green I-based duplex real-time polymerase chain reaction analysis

Wang

Cui

et al. 2020

Molecular and Cellular Probes

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Beak atrophy and dwarfism syndrome (BADS) is commonly caused by co-infection with duck circovirus (DuCV) and novel goose parvovirus (NGPV). Therefore, concurrent detection of both viruses is important for monitoring and limiting BADS, although such a diagnostic test has not been reported. In this study, we developed a duplex, SYBR Green I-based real-time polymerase chain reaction (PCR) assay to enable the simultaneous detection of DuCV and NGPV. The assay readily distinguished between the two viruses, based on their different melting temperatures (Tm), where the Tm for DuCV was 80 °C and that for NGPV was 84.5 °C. Other non-target duck viruses that were tested did not show melting peaks. The detection limit of the duplex assay was 10 1 copies/μL for both viruses. This method exhibited high repeatability and reproducibility, and both the inter-assay and intra-assay variation coefficients were <1.6%. Thirty-one fecal samples were collected for clinical testing using real-time PCR analysis, and the results were confirmed using sequencing. The rate of co-infection was 6.5%, which was consistent with the sequencing results. This duplex real-time PCR assay offers advantages over other tests, such as rapid, sensitive, specific, and reliable detection of both viruses in a single sample, which enables the quantitative detection of DuCV and NGPV in clinical samples. Using this test may be instrumental in reducing the incidence of BADS and the associated economic losses in the duck and goose industries.

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Novel goose parvovirus in domestic Linwu sheldrakes with short beak and dwarfism syndrome, China

Cited by 15 publications

References 14 publications

Whole Genome Characterization and Genetic Evolution Analysis of a New Ostrich Parvovirus

Whole Genome Characterization and Genetic Evolution Analysis of a New Ostrich Parvovirus

Effect of goose parvovirus and duck circovirus coinfection in ducks

Simultaneous detection of duck circovirus and novel goose parvovirus via SYBR green I-based duplex real-time polymerase chain reaction analysis

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