Effect of goose parvovirus and duck circovirus coinfection in ducks

Liu, Jie; Yang, Xiaoxia; Hao, Xiaoyan; Feng, Yujian; Zhang, Yuli; Cheng, Ziqiang

doi:10.2478/jvetres-2020-0048

Cited by 17 publications

(2 citation statements)

References 29 publications

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“…Interestingly, in the more recent study, nGPV with distinct mutation pattern in Vp3 protein was isolated from feather sacks of ducks suffering from feather shedding syndrome that is caused by DuCV [ 26 ]. Recently, the effect of co-infections was studied in detail in experimental settings [ 27 ]. It was observed that after the initial lower viral loads, the loads of both nGPV and DuCV in dually infected birds were higher compared to those infected with only one pathogen.…”

Section: Discussionmentioning

confidence: 99%

Short Beak and Dwarfism Syndrome in Ducks in Poland Caused by Novel Goose Parvovirus

Matczuk

Chmielewska-Władyka

Siedlecka

et al. 2020

Animals

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Short beak and dwarfism syndrome (SBDS), which was previously identified only in mule ducks, is now an emerging disease of Pekin ducks in China and Egypt. The disease is caused by the infection of ducks with a genetic variant of goose parvovirus—novel goose parvovirus (nGPV). In 2019, SBDS was observed for the first time in Poland in eight farms of Pekin ducks. Birds in the affected flock were found to show growth retardation and beak atrophy with tongue protrusions. Morbidity ranged between 15% and 40% (in one flock), while the mortality rate was 4–6%. Co-infection with duck circovirus, a known immunosuppressive agent, was observed in 85.7% of ducks. The complete coding regions of four isolates were sequenced and submitted to GenBank. The phylogenetic analysis revealed a close relationship of Polish viral sequences with the Chinese nGPV. Genomic sequence alignments showed 98.57–99.28% identity with the nGPV sequences obtained in China, and 96.42% identity with the classical GPV (cGPV; Derzsy’s disease). The rate of amino acid mutations in comparison to cGPV and Chinese nGPV was higher in the Rep protein than in the Vp1 protein. To our knowledge, this is the first report of nGPV infection in Pekin ducks in Poland and Europe. It should be emphasized that monitoring and sequencing of waterfowl parvoviruses is important for tracking the viral genetic changes that enable adaptation to new species of waterbirds.

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Section: Discussionmentioning

confidence: 99%

Short Beak and Dwarfism Syndrome in Ducks in Poland Caused by Novel Goose Parvovirus

Matczuk

Chmielewska-Władyka

Siedlecka

et al. 2020

Animals

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“…DuCV is an important co-factor in duck enteritis virus, goose parvovirus, and Riemerella anatipestifer infections (Neale et al, 2022), but the mechanism by which the virus causes the disease is not fully understood. DuCV infection combined with goose parvovirus increases the prevalence of short beak and dwarfism syndrome in meat-type ducks (Liu et al, 2020). The disease induced by DuCV may result from virus-induced immunopathological disorders.…”

Section: Introductionmentioning

confidence: 99%

Generation of a monoclonal antibody against duck circovirus capsid protein and its potential application for native viral antigen detection

Liu

Ren

et al. 2023

Front. Microbiol.

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IntroductionDuck circovirus (DuCV) infection is currently recognized as an important immunosuppressive disease in commercial duck flocks in China. Specific antibodies against DuCV viral proteins are required to improve diagnostic assays and understand the pathogenesis of DuCV infection.Methods and resultsTo generate DuCV-specific monoclonal antibodies (mAbs), a recombinant DuCV capsid protein without the first 36 N-terminal amino acids was produced in Escherichia coli. Using the recombinant protein as an immunogen, a mAb was developed that reacted specifically with the DuCV capsid protein, expressed in E. coli and baculovirus systems. Using homology modeling and recombinant truncated capsid proteins, the antibody-binding epitope was mapped within the region of 144IDKDGQIV151, which is exposed to solvent in the virion capsid model structure. To assess the applicability of the mAb to probe the native virus antigen, the murine macrophage cell line RAW267.4 was tested for DuCV replicative permissiveness. Immunofluorescence and Western blot analysis revealed that the mAb recognized the virus in infected cells and the viral antigen in tissue samples collected from clinically infected ducks.DiscussionThis mAb, combined with the in vitro culturing method, would have widespread applications in diagnosing and investigating DuCV pathogenesis.

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Development and application of a multiplex qPCR assay for the detection of duck circovirus, duck Tembusu virus, Muscovy duck reovirus, and new duck reovirus

et al. 2022

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Effect of goose parvovirus and duck circovirus coinfection in ducks

Cited by 17 publications

References 29 publications

Short Beak and Dwarfism Syndrome in Ducks in Poland Caused by Novel Goose Parvovirus

Short Beak and Dwarfism Syndrome in Ducks in Poland Caused by Novel Goose Parvovirus

Generation of a monoclonal antibody against duck circovirus capsid protein and its potential application for native viral antigen detection

Development and application of a multiplex qPCR assay for the detection of duck circovirus, duck Tembusu virus, Muscovy duck reovirus, and new duck reovirus

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