Novel flow injection strategies for study and control of matrix interferences by inductively coupled plasma time-of-flight mass spectrometry

McClenathan, Denise M.; Ray, Steven J.; Hieftje, Gary M.

doi:10.1039/b104047m

Cited by 26 publications

(25 citation statements)

References 8 publications

(9 reference statements)

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“…Hence, the peaks for the different elements were divided point by point by those corresponding to an element (acting as IS). 34 This procedure was followed for the plain water solution and for the nitric acid, sodium and acetic acid solutions. Fig.…”

Section: Analytical Signalmentioning

confidence: 99%

Compensation for matrix effects in ICP-AES by using air segmented liquid microsample introduction. The role of the spray chamber

Todolı́¹,

Pérez²,

Mermet³

2004

J. Anal. At. Spectrom.

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The combination of sample injection into an air carrier stream (i.e., air segmentation) with a low sample consumption system has been evaluated for the analysis of microsamples through ICP-AES. A PFA micronebulizer has been coupled to: (i), a double pass spray chamber; (ii), a Cinnabar cyclonic spray chamber; and (iii), a torch integrated sample introduction system, TISIS. Three matrices have been studied: in addition to water two concentrated acid solutions (2 mol l 21 nitric acid and 1.7 mol l 21 acetic acid) and Na 5,000 mg ml 21 . A simulation of the evolution of the drop size distributions of the aerosols with time was carried out in order to evaluate the extent of solvent evaporation inside the chamber. The total mass of solvent evaporated inside the chamber was estimated and it was concluded that, at 25 uC, about 4-6 s residence time were required to promote the maximum evaporation of the solvent. In order to ensure this, discrete sample introduction into an air carrier stream (i.e., air segmentation) was used. Narrow peaks (i.e., with a full width at half maximum, FWHM, as short as 10 s) were obtained for a 10 ml injected sample. The peaks found for the Cinnabar and TISIS were narrower than those for the double pass spray chamber. More importantly, the interferences caused by inorganic as well as organic matrices were less severe in discrete than in continuous mode. The theoretical simulations allowed explanation of these results in terms of the enhancement of the solvent evaporation both for water and matrices in this operating mode. The enhanced solvent evaporation with respect to the situation in continuous mode minimized differences in analyte transport towards the plasma induced by these compounds. Despite this, in discrete mode a residual matrix effect was found that was attributed to the aerosol transport process. Internal standardization (IS) was applied to transient signals and the interferences were compensated for in virtually all the cases. Good results were obtained for the four emission lines taken as internal standards (i.e., Mg 280.270, Co 228.616, Cr 205.552 and Cu 324.754). However, for acetic acid and a few lines, IS was not efficient for removing interferences. The methodology was validated by analyzing two reference solid samples of foods (i.e., bovine liver and mussel tissue). By using Cd 214.438 as internal standard and under discrete mode 100% recoveries were found.In the field of ICP techniques, the analysis of microsamples is an issue of recent interest.1 Among the different methods, the use of a micronebulizer coupled to a low inner volume spray chamber has reached acceptance because of its simplicity and reliability.2 Pneumatic micronebulizers are widely used for applications requiring consumption of only several microliters of solution per minute. As regards the spray chamber, besides double pass designs, the so called Cinnabar has been extensively used for the analysis of microsamples.3,4 The Cinnabar chamber is of cyclonic type but has a low inner volume so as to shorten th...

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Section: Analytical Signalmentioning

confidence: 99%

Compensation for matrix effects in ICP-AES by using air segmented liquid microsample introduction. The role of the spray chamber

Todolı́¹,

Pérez²,

Mermet³

2004

J. Anal. At. Spectrom.

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“…136 The advantages of ICP-TOF-MS over sequential mass analyzers for fast transient detection and the simultaneous determination of a large number of isotopes in the flow injection (FI) peaks in trace metal analysis have been discussed. [137][138][139][140][141] The absence of spectral skew is highly appreciated. The applicability of a combined FI-hydride generation (HG)-ICP-TOF-MS system to the determination of As, Bi, Ge, Hg, Sb, Se and Sn in urine samples has been examined.…”

Section: Applications Of Icp-tof-ms Technique In Elemental Analysismentioning

confidence: 99%

“…The use of gradient dilution flow injection systems has been recommended for the identification of matrix effects and the reduction of interferences in FI-ICP-TOF-MS analysis. 140 Simultaneous ion extraction and full elemental coverage in ICP-TOF-MS provide significant improvement in the isotope ratio precision as compared with other mass spectrometric techniques. The great potential of ICP-TOF-MS for isotope ratios evaluation has been demonstrated.…”

Section: Applications Of Icp-tof-ms Technique In Elemental Analysismentioning

confidence: 99%

“…The ICP-TOF-MS has been successfully coupled to LA, [120][121][122][123][124][125][126] ETV, 127 GC, [128][129][130][131][132] liquid chromatography, 133,134 CE 135,136 and FIA. [137][138][139][140][141] Detailed reviews of the development and analytical performance of TOF-MS combined with ICP ion source have been presented. [142][143][144][145] Attempts to couple TOF-MS to a microwave induced plasma (MIP) for elemental analysis have also been described.…”

Section: An Overview Of Analytical Applications Of Tof-ms Analyzersmentioning

confidence: 99%

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An Overview of Analytical Applications of Time of Flight-Mass Spectrometric (TOF-MS) Analyzers and an Inductively Coupled Plasma-TOF-MS Technique

Balcerzak

2003

ANAL. SCI.

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“…Analyte signal enhancements or suppressions can be caused by concomitant species in the sample matrix, often resulting in serious errors. Although recognition and study of matrix effects are often difficult and time-consuming, exploiting the concentration change that occurs in a single flow-injection peak allows them to be studied by ICP-TOFMS (42). By creating a concentration gradient of a known interferent within a constant analyte concentration, signal enhancements or suppressions were monitored as a function of time and, therefore, matrix concentration.…”

Section: Mitigating Interferencesmentioning

confidence: 99%

Peer Reviewed: Plasma Source TOFMS

McClenathan¹,

Ray²,

Wetzel³

et al. 2004

Anal. Chem.

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Novel flow injection strategies for study and control of matrix interferences by inductively coupled plasma time-of-flight mass spectrometry

Cited by 26 publications

References 8 publications

Compensation for matrix effects in ICP-AES by using air segmented liquid microsample introduction. The role of the spray chamber

Compensation for matrix effects in ICP-AES by using air segmented liquid microsample introduction. The role of the spray chamber

An Overview of Analytical Applications of Time of Flight-Mass Spectrometric (TOF-MS) Analyzers and an Inductively Coupled Plasma-TOF-MS Technique

Peer Reviewed: Plasma Source TOFMS

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