Novel Fatty Acid in <i>Cordyceps</i> Suppresses Influenza A (H1N1) Virus-Induced Proinflammatory Response Through Regulating Innate Signaling Pathways

Li, Runfeng; Zhou, Xiaobo; Zhou, Hongxia; Yang, Zifeng; Jiang, Haiming; Wu, Xiao Y.; Li, Wenjia; Qiu, Jian-Jian; Mi, Jianing; Chen, Ming; Zhong, Nanshan; Zhu, Guo‐Yuan; Jiang, Zhihong

doi:10.1021/acsomega.0c05264

Cited by 15 publications

(11 citation statements)

References 49 publications

(89 reference statements)

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“…Moreover, DDEA significantly reduced the protein expression levels of TLR3, RIG-I, phospho-IRF3, and phospho-NF-κB p65 in infected cells. It is suggested that DDEA may regulate the immune function by regulating TLR3 and RIG-I-dependent signaling pathways (Li et al, 2021).…”

Section: (2z4e)-deca-24-dienoic Acid (Ddea)mentioning

confidence: 99%

Research progress on the effect of traditional Chinese medicine on the activation of PRRs-mediated NF-κB signaling pathway to inhibit influenza pneumonia

et al. 2023

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Influenza pneumonia has challenged public health and social development. One of the hallmarks of severe influenza pneumonia is overproduction of pro-inflammatory cytokines and chemokines, which result from the continuous activation of intracellular signaling pathways, such as the NF-κB pathway, mediated by the interplay between viruses and host pattern recognition receptors (PRRs). It has been reported that traditional Chinese medicines (TCMs) can not only inhibit viral replication and inflammatory responses but also affect the expression of key components of PRRs and NF-κB signaling pathways. However, whether the antiviral and anti-inflammatory roles of TCM are related with its effects on NF-κB signaling pathway activated by PRRs remains unclear. Here, we reviewed the mechanism of PRRs-mediated activation of NF-κB signaling pathway following influenza virus infection and summarized the influence of anti-influenza TCMs on inflammatory responses and the PRRs/NF-κB signaling pathway, so as to provide better understanding of the mode of action of TCMs in the treatment of influenza pneumonia.

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Section: (2z4e)-deca-24-dienoic Acid (Ddea)mentioning

confidence: 99%

Research progress on the effect of traditional Chinese medicine on the activation of PRRs-mediated NF-κB signaling pathway to inhibit influenza pneumonia

et al. 2023

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“…DDEA, a fatty acid in Cordyceps sinensis , can reduce the level of inflammation caused by infection with H1N1 and reduce the secretion of inflammatory factors in cells. The anti-inflammatory effect is achieved by regulating the innate immune signal pathway activated by TLR-3-, RIG-I- and type I interferon [ 27 ]. A new polysaccharide PCP-II was isolated from Poria cocos .…”

Section: Antiviral Activitymentioning

confidence: 99%

“…It was found that four species of Pleurotus ostreatus , Fomes fomentarius , Auriporia aurea , and Trametes versicolor had an inhibitory effect on the virus. The highest treatment index of T. versicolor was 324.67 [ 27 ].…”

Section: Antiviral Activitymentioning

confidence: 99%

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Medicinal Fungi with Antiviral Effect

Zhang

Ling

2022

Molecules

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Pandemics from various viruses make natural organisms face challenges over and over again. Therefore, new antiviral drugs urgently need to be found to solve this problem. However, drug research and development is a very difficult task, and finding new antiviral compounds is desirable. A range of medicinal fungi such as Ganoderma lucidum and Cordyceps sinensis are widely used all over the world, and they can enhance human immunity and direct anti-virus activities and other aspects to play an antiviral role. Medicinal fungi are used as foods or as food supplements. In this review, the species of medicinal fungi with antiviral activity in recent decades and the mechanism of antiviral components were reviewed from the perspectives of human, animal, and plant viruses to provide a comprehensive theory based on better clinical utilization of medicinal fungi as antiviral agents.

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“…Zhong et al found that the water extract of OS had significant anti-inflammatory effects against single stimulation by cigarette smoke extract (CSE), as well as infection by a compound influenza virus [ 12 ]. A UHPLC-Q-TOF-MS technique was used to extract a novel fatty acid—(2Z,4e)-deca-2,4-dienoic acid—from CSE, which attenuated the inflammatory response by reducing mRNA and protein levels in cells [ 13 ]. The same study also found that OS contains a water-insoluble polysaccharide, β-(1,3) glucan, which is not only a component of fungal cell walls, but it is also the core structure of immunologically active polysaccharides that stimulate immune receptors such as Dectin-1 to trigger innate immune responses; this suggests that there may a large number of unknown active ingredients in OS, which could play an important role in the prevention and treatment of diseases.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Widely Targeted Metabolomics and Untargeted Metabolomics of Wild Ophiocordyceps sinensis

et al. 2022

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The authors of this paper conducted a comparative metabolomic analysis of Ophiocordyceps sinensis (OS), providing the metabolic profiles of the stroma (OSBSz) and sclerotia (OSBSh) of OS by widely targeted metabolomics and untargeted metabolomics. The results showed that 778 and 1449 metabolites were identified by the widely targeted metabolomics and untargeted metabolomics approaches, respectively. The metabolites in OSBSz and OSBSh are significantly differentiated; 71 and 96 differentially expressed metabolites were identified by the widely targeted metabolomics and untargeted metabolomics approaches, respectively. This suggests that these 71 metabolites (riboflavine, tripdiolide, bromocriptine, lumichrome, tetrahymanol, citrostadienol, etc.) and 96 metabolites (sancycline, vignatic acid B, pirbuterol, rubrophen, epalrestat, etc.) are potential biomarkers. 4-Hydroxybenzaldehyde, arginine, and lumichrome were common differentially expressed metabolites. Using the widely targeted metabolomics approach, the key pathways identified that are involved in creating the differentiation between OSBSz and OSBSh may be nicotinate and nicotinamide metabolism, thiamine metabolism, riboflavin metabolism, glycine, serine, and threonine metabolism, and arginine biosynthesis. The differentially expressed metabolites identified using the untargeted metabolomics approach were mainly involved in arginine biosynthesis, terpenoid backbone biosynthesis, porphyrin and chlorophyll metabolism, and cysteine and methionine metabolism. The purpose of this research was to provide support for the assessment of the differences between the stroma and sclerotia, to furnish a material basis for the evaluation of the physical effects of OS, and to provide a reference for the selection of detection methods for the metabolomics of OS.

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Novel Fatty Acid in Cordyceps Suppresses Influenza A (H1N1) Virus-Induced Proinflammatory Response Through Regulating Innate Signaling Pathways

Cited by 15 publications

References 49 publications

Research progress on the effect of traditional Chinese medicine on the activation of PRRs-mediated NF-κB signaling pathway to inhibit influenza pneumonia

Research progress on the effect of traditional Chinese medicine on the activation of PRRs-mediated NF-κB signaling pathway to inhibit influenza pneumonia

Medicinal Fungi with Antiviral Effect

Comparison of Widely Targeted Metabolomics and Untargeted Metabolomics of Wild Ophiocordyceps sinensis

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