“…This amount is lower than that in kaolinite (39.5%) and montmorillonite (16.54%) which have been widely used in medicine. 40 Nano-ATP was proved non-toxic in the early 1990s, 46 , 47 and several nano-ATP composite materials have been fabricated in our previous study, and in vitro and in vivo studies have confirmed the biocompatibility and the capability to promote osteogenesis. 48 , 49 Figure 1 Morphology and rheological characterization of Gel/SA/nano-ATP composite hydrogel scaffolds with different nano-ATP contents.…”
Introduction
Bone tissue engineering (BTE) is a new strategy for bone defect repair, but the difficulties in the fabrication of scaffolds with personalized structures still limited their clinical applications. The rapid development in three-dimensional (3D) printing endows it capable of controlling the porous structures of scaffolds with high structural complexity and provides flexibility to meet specific needs of bone repair.
Methods
In this study, sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds doped with different contents of nano-attapulgite were fabricated via 3D printing. The surface microstructure, hydrophilicity and mechanical properties were fully evaluated. Furthermore, mouse bone marrow-derived mesenchymal stem cells (BMSCs) were cultured with the composite hydrogels in vitro, and proliferation and osteoblastic differentiation were assessed. A rabbit tibia plateau defect model was used to evaluate the osteogenic potential of the composite hydrogel in vivo.
Results
When increasing nano-ATP content, the Gel/SA/nano-ATP composite hydrogels showed better mechanical property and printability. Moreover, Gel/SA/nano-ATP composite hydrogels showed excellent bioactivity, and a significant mineralization effect was observed on the surface after being incubated in simulated body fluid (SBF) for 14 days. The Gel/SA/nano-ATP composite hydrogel also showed good biocompatibility and promoted the osteogenesis of BMSCs. Finally, histological analysis demonstrates that the Gel/SA/nano-ATP composite hydrogels could effectively enhance bone regeneration in vivo.
Conclusion
These properties render the Gel/SA/nano-ATP composite hydrogel scaffolds an ideal bone tissue engineering material for the repair of bone defects.
“…This amount is lower than that in kaolinite (39.5%) and montmorillonite (16.54%) which have been widely used in medicine. 40 Nano-ATP was proved non-toxic in the early 1990s, 46 , 47 and several nano-ATP composite materials have been fabricated in our previous study, and in vitro and in vivo studies have confirmed the biocompatibility and the capability to promote osteogenesis. 48 , 49 Figure 1 Morphology and rheological characterization of Gel/SA/nano-ATP composite hydrogel scaffolds with different nano-ATP contents.…”
Introduction
Bone tissue engineering (BTE) is a new strategy for bone defect repair, but the difficulties in the fabrication of scaffolds with personalized structures still limited their clinical applications. The rapid development in three-dimensional (3D) printing endows it capable of controlling the porous structures of scaffolds with high structural complexity and provides flexibility to meet specific needs of bone repair.
Methods
In this study, sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds doped with different contents of nano-attapulgite were fabricated via 3D printing. The surface microstructure, hydrophilicity and mechanical properties were fully evaluated. Furthermore, mouse bone marrow-derived mesenchymal stem cells (BMSCs) were cultured with the composite hydrogels in vitro, and proliferation and osteoblastic differentiation were assessed. A rabbit tibia plateau defect model was used to evaluate the osteogenic potential of the composite hydrogel in vivo.
Results
When increasing nano-ATP content, the Gel/SA/nano-ATP composite hydrogels showed better mechanical property and printability. Moreover, Gel/SA/nano-ATP composite hydrogels showed excellent bioactivity, and a significant mineralization effect was observed on the surface after being incubated in simulated body fluid (SBF) for 14 days. The Gel/SA/nano-ATP composite hydrogel also showed good biocompatibility and promoted the osteogenesis of BMSCs. Finally, histological analysis demonstrates that the Gel/SA/nano-ATP composite hydrogels could effectively enhance bone regeneration in vivo.
Conclusion
These properties render the Gel/SA/nano-ATP composite hydrogel scaffolds an ideal bone tissue engineering material for the repair of bone defects.
“…The XRD spectrum of APT shows peaks at 2θ = 8.4°, 13.64°, 16.46°, 19.78°, 20.86°, 21.39°, 27.48° and 35.34°. These are the characteristic crystallization peaks corresponding to crystal faces: (110), (200), (130), (040), (121), (240), (400), and (311) [ 50 ], which match well with the standard attapulgite patterns of JCPDS card No. 21-0958.…”
Removing heavy metal ions from industrial wastewater is one of the most important and difficult areas of the water treatment industry. In this study, Bacterial Cellulose/Polyvinyl Alcohol/Graphene Oxide/Attapulgite (BC/PVA/GO/APT) composites were successfully prepared via a repeated freeze-thaw method using bacterial cellulose, polyvinyl alcohol as the skeleton, and graphene oxide, attapulgite as fillers. The capacities of adsorbing Cu2+ and Pb2+ ions in solution were investigated. FTIR, XRD, SEM, BET, and TG-DSC analyses showed that the BC/PVA/GO/APT hydrogel has a better hydrophilicity, a larger specific surface area and a better thermal stability than traditional materials. We found that the adsorption of Cu2+ and Pb2+ ions can be accurately predicted by the Freundlich kinetic model, and the optimal adsorption capacities of these ions were found to be 150.79 mg/g and 217.8 mg/g respectively. Thermodynamic results showed that the adsorption process is spontaneous and exothermic. BC/PVA/GO/APT composites are suggested to be an ideal adsorption material for removing heavy metal ions from industrial wastewater.
“…Chitosan performed well in ionic adsorption studies [30,31]. In this study, blood clotting was reduced, which could be ascribed to the adsorption of calcium ions by Fe 3 O 4 @Chi NCs [32]. Furthermore, due to the good adsorption effect of chitosan, plasma proteins might be adsorbed, which might lead to side effects.…”
Excess lactic acid in blood will lead to hyperlactatemia, which is frequently detected in critically ill patients admitted to the intensive care. Reducing the blood lactic acid content using acute treatments becomes particularly important for bringing a patient out of danger. Traditional treatments often fail in case of malfunctioning of a patients' metabolism. Herein, nanotechnology was introduced to remove blood lactic acid independent of metabolism. In this work, chitosan was employed as the shell to adsorb lactic acid, and Fe 3 O 4 nanoparticles were employed as the core to enable proper magnetic separation property. Our data showed that core-shell nanocomposites (NCs) had an exigent and efficient adsorption behavior. Furthermore, they could be easily separated from blood plasma by magnetic separation. Thus, the good hemocompatibility and cytocompatibility indicated that of coreshell NCs hold great potential in lactic acid removal for emergent hyperlactatemia treatment.
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